DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment drpr and Stab2

DIOPT Version :9

Sequence 1:NP_001261276.1 Gene:drpr / 38218 FlyBaseID:FBgn0027594 Length:1042 Species:Drosophila melanogaster
Sequence 2:NP_619614.1 Gene:Stab2 / 192188 MGIID:2178743 Length:2559 Species:Mus musculus


Alignment Length:1749 Identity:311/1749 - (17%)
Similarity:439/1749 - (25%) Gaps:913/1749 - (52%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MLPVILIACLAQLVLAQADLKDLDGPNICKRRELYNVDVVYTELQSFQERGSTWC-VTFPPRCST 64
            :||:||| .|..||  |......:.|.:.||.:..:...:.||.||        | |....:|..
Mouse    11 LLPLILI-FLGLLV--QNACSPTEAPELTKRCDKKSTLTIKTECQS--------CSVNIAVKCPD 64

  Fly    65 YRIKHRVVNKTKTIAKNRIVRDC-----CDGYIASAGECVPHCSEPCQHGRCISPEKCKCDHGYG 124
            ..||  :.|.|..      ||||     ...|:..    :|.|...|:.. .:.|:.|.   |:.
Mouse    65 GYIK--ITNGTVG------VRDCRYSLKIQSYVLD----IPGCRHICRKD-YLQPQCCP---GHW 113

  Fly   125 GPACDINCPPGWYGRNCSMQCDCLNNAVCE---PFSGDCECAKGYTGARCADICPEGFFGANCSE 186
            ||.| :.||.|       .:..|....||:   ..:|.|.|..|:.|..|.:...|..||.|||.
Mouse   114 GPDC-MECPGG-------ARAPCGGRGVCDEGMEGTGSCSCRAGFRGTACENCAAEDVFGPNCSA 170

  Fly   187 KCRCENGGKCHHVSGE--CQCAPGFTGPLCD--------MRCPDGKHGAQCQQD-----CPC--- 233
            .|.|.:|.....:||:  |:|...:.||.||        :.||:....:...:|     |.|   
Mouse   171 VCSCVHGVCNSGISGDGTCECLSAYRGPRCDKPIPECAALLCPENSRCSPSSKDETKLQCKCLPS 235

  Fly   234 -QNDGK------------CQPETG---------ACMCNPGWTGD--VCA---------NKCPVGS 265
             :.||:            |.|...         :|:|..|:.||  ||.         ..||..|
Mouse   236 YKGDGQTCKPINPCLKNVCHPHASCSYLGPNRHSCVCQKGYQGDGQVCLPVDPCQTSYGNCPTKS 300

  Fly   266 Y-----GPG-----CQES---------------CE----CYKGAPCHHIT---GQCECPPGYRGE 298
            .     |||     |:|.               ||    |:|.|.|..::   .||.|..||.|:
Mouse   301 TVCRYDGPGQSHCECKEHYRNFVPGVGCSMTDICESKNPCHKNANCSTVSPGQTQCTCQKGYVGD 365

  Fly   299 --RCFDEC-----QLN--------------------TYGFNCS---------------------- 314
              .|:...     :||                    ||.:..|                      
Mouse   366 GLNCYGNIMQRLRELNTEPRGMWQGQLTSFISILDRTYAWPLSNLGPFTVLLPSDKGLKGVDVKE 430

  Fly   315 --MTCDCAN-------------------------------------------------------- 321
              |..:.|.                                                        
Mouse   431 LLMDKEAARYFVKLHIIAGQMSTEQMYNLDTFYTLTGKSGEIINKDKDNQLKLKLYGSKIVQIIQ 495

  Fly   322 -------------DAMCDRANGTCICNPGWT---------------------------------- 339
                         |...|:...|...||..|                                  
Mouse   496 GNIVASNGLVHILDRAMDKIEPTLESNPQQTIMTMLQPRYGKFRSLLEKTNVGQALEKGGIDEPY 560

  Fly   340 ----------------------GAKCAERICE--------------------------------- 349
                                  ..:.:.::.|                                 
Mouse   561 TIFVPSNEALSNMTAGVLDYLLSPEGSRKLLELVRYHIVAFTQLEVATLVSTLHIRSMANQIITF 625

  Fly   350 ---------ANKYGLD------------------------------CNR--------TC-ECDME 366
                     ||...:|                              ||.        || .|.|:
Mouse   626 NISSKGQILANNVAVDETEVAAKNGRIYTLTGVLIPPSILPILPHRCNETKREMKLGTCVRCFMK 690

  Fly   367 HTDLCHPE-------TGNC-QCSIGWS-SAQCTRPCTFLRYGPNCELTCNCKN--GAKCSPV--- 417
            :...|...       |..| ..|..|: ...|.|.|......|.|     ||.  |..|:|.   
Mouse   691 NWSKCPTNSEPTAIFTNKCFYGSRAWNLKIGCARYCDVTVEIPRC-----CKGFFGPDCNPCPGG 750

  Fly   418 -----------------NGTCLCAPGWRGPTCEESCEPGTFGQDCALRCDCQNGAKCE---PETG 462
                             ||||:|..|::|..|:...:|..:|..|...|.|.:|. |:   ...|
Mouse   751 FMNPCSGNGQCIDGLGGNGTCICEDGFQGSRCQFCSKPNRYGPQCNRTCQCVHGI-CDNRLDSDG 814

  Fly   463 QCL---CTAGWKNIKCDRPCDLNHFGQDCAKVCD-CHNNAACNPQN--GSCTCAAGWTGE--RCE 519
            .||   |..|.....||:....      |..... ||.:|.|...|  .||.|..|:.|:  .|.
Mouse   815 SCLPGTCREGTAGRFCDKQTSA------CGPYMQFCHIHATCEYSNETASCVCNDGYEGDGTLCS 873

  Fly   520 RK--C--DTGKFGHDCAQKCQCDFNNSLACDATNG--RCVCKQDW------------------GG 560
            :|  |  .|.:.|  |:...:|       ..|:.|  .|||::.|                  ||
Mouse   874 KKDPCLGSTSRGG--CSPNAEC-------IQASTGTYSCVCQRGWTGNGRDCVEINSCLLPSSGG 929

  Fly   561 VH----C--------ETNCRSGYYGE--NCDKVCRCLNN-SSCDP-------DSG--NCICSAGW 601
            .|    |        |..|:.|:.|.  :|:.:..||.. ..|.|       .||  :|:|..|:
Mouse   930 CHDNATCLYVGPGQNECECKKGFRGNGIDCEPIISCLEQIEKCHPLATCQYTLSGVWSCVCQEGY 994

  Fly   602 TG--------------------------------------------------------------- 603
            .|                                                               
Mouse   995 EGNGVLCYGNVLMELSFLSEAAVFYQWINNASLQSMLSATSNLTVLVPSLQAIKDMDQNEKSFWL 1059

  Fly   604 ----------------------------------------------------------------- 603
                                                                             
Mouse  1060 SRNNIPALIKYHTLLGTYRVADLQTLPSSHMLATSLQGSFLRLDKADGNITIEGASFVDGDNAAT 1124

  Fly   604 ----------------------------------------------------ADCAEPCPP---- 612
                                                                ||......|    
Mouse  1125 NGVVHIINKVLIPQRGLTGSLPSLLTRLEQMPDYSIFRGYIIHYNLASAIEAADAYTVFVPNNEA 1189

  Fly   613 -------------------------------------------GF-------------------- 614
                                                       ||                    
Mouse  1190 IESYIREKKATSLKEDILQYHVVLGEKLLRNDLHNGMHRETMLGFSYLLAFFLHNDQLYVNEAPI 1254

  Fly   615 ------------YGME-----CKERCPE----ILHGNKSCDHITGEILC---------------- 642
                        :|:|     .|.||..    |:.|  .|...:.:.||                
Mouse  1255 NYTNVATDKGVIHGLEKVLEIKKNRCDNNDTIIVRG--KCGKCSQQTLCPLETKPLSETRKCIYS 1317

  Fly   643 ------RTGYIG--LTC-----EHPCPAGLYGPGCKLKCN------CEHGGEC---NHVTGQCQC 685
                  |:.:||  |.|     ...|.||.:||.|: .|.      |...|.|   .:.||.|:|
Mouse  1318 VYFMGKRSIFIGCQLQCVRTIITSACCAGFFGPQCQ-ACPGKGQNVCSGNGFCLDGVNGTGTCEC 1381

  Fly   686 LPGWTGSNCNESCPTDTYGQGCAQRCRCVHHKVCRK---ADGMCICETGWSGTRCD-EV------ 740
            ..|:.|:.| |:|....||..|.|.|.|||.: |.:   .||.|.|:.||.|.:|| |:      
Mouse  1382 EQGFNGTAC-ETCTEGKYGIHCDQACSCVHGR-CNQGPSGDGSCDCDVGWRGVKCDSEITTDNCN 1444

  Fly   741 --------------------CPEGFYGEH--CMNTCACPSANFQCHA----------AHGCVCRS 773
                                |..||.|..  |....||..:|..|.|          :..|||::
Mouse  1445 GTCHTSANCLLDPDGKASCKCAAGFQGNGTVCTAINACEISNGGCSAKADCKRTIPGSRVCVCKA 1509

  Fly   774 GYTGD---------------NCDELIASQRIADQSENSSRASVALTL--------VLMTLFACII 815
            |||||               .||      |.|:.::.....:|...|        |...:..|:.
Mouse  1510 GYTGDGIVCLEINPCLENHGGCD------RHAECTQTGPNQAVCNCLPKYTGDGKVCTLINVCLT 1568

  Fly   816 ----FAVFIYYRRRVSNLKTEIAHVHYTHD------TNPPSWPPNHNFDNPVYGMQAE------- 863
                .:.|.:......:.:|......||.|      :.....|.|.:.....:.:|..       
Mouse  1569 NNGGCSPFAFCNHTEQDQRTCTCKPDYTGDGIVCRGSIHSELPKNPSTSQYFFQLQEHAVQELAG 1633

  Fly   864 ----TRLLPN----NMRSKMNNFDQRSTMSTDYGDDCNASGRVGSYSINYNHDLLTKNL 914
                |..:|:    |..||:..:|::..||           ::..|.:.....||.:||
Mouse  1634 PGPFTVFVPSSDSFNSESKLKVWDKQGLMS-----------QILRYHVVACQQLLLENL 1681

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
drprNP_001261276.1 EMI 27..92 CDD:284877 17/70 (24%)
EGF_CA 274..319 CDD:304395 19/102 (19%)
DSL <479..518 CDD:302925 11/43 (26%)
DSL <567..606 CDD:302925 15/230 (7%)
Stab2NP_619614.1 EGF_3 254..283 CDD:289699 7/28 (25%)
EGF_3 334..369 CDD:289699 12/34 (35%)
Fasciclin 390..512 CDD:280607 6/121 (5%)
Fasciclin 533..661 CDD:280607 4/127 (3%)
EGF_3 844..872 CDD:289699 10/27 (37%)
EGF_3 928..959 CDD:289699 8/30 (27%)
EGF_3 965..1001 CDD:289699 10/35 (29%)
Fasciclin 1018..1137 CDD:280607 0/118 (0%)
Fasciclin 1156..1273 CDD:280607 7/116 (6%)
EGF_3 1482..1518 CDD:289699 12/35 (34%)
EGF_3 1524..1560 CDD:289699 6/41 (15%)
EGF_3 1566..1602 CDD:289699 6/35 (17%)
Fasciclin 1628..1733 CDD:280607 13/65 (20%)
Fasciclin 1758..1889 CDD:280607
EGF_3 2094..2129 CDD:289699
EGF_3 2135..2172 CDD:289699
Link_Domain 2206..2297 CDD:295393
FAS1 2363..2452 CDD:214719
Interaction with TMSB4X. /evidence=ECO:0000250 2510..2520
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2514..2559
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1218
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.900

Return to query results.
Submit another query.