Protein Alignment drpr and Stab2

DIOPT Version :10

• Sequence 1: NP_001261276.1
• Gene: drpr / 38218
• FlyBaseID: FBgn0027594
• Length: 1042
• Species: Drosophila melanogaster
• Sequence 2: NP_619614.1
• Gene: Stab2 / 192188
• MGIID: 2178743
• Length: 2559
• Species: Mus musculus
• Alignment Length: 1749
• Identity: 311/1749 - (17%)
• Similarity: 439/1749 - (25%)
• Gaps: 913/1749 - (52%)

  Fly     1 MLPVILIACLAQLVLAQADLKDLDGPNICKRRELYNVDVVYTELQSFQERGSTWC-VTFPPRCST 64
            :||:||| .|..||  |......:.|.:.||.:..:...:.||.||        | |....:|..
Mouse    11 LLPLILI-FLGLLV--QNACSPTEAPELTKRCDKKSTLTIKTECQS--------CSVNIAVKCPD 64

  Fly    65 YRIKHRVVNKTKTIAKNRIVRDC-----CDGYIASAGECVPHCSEPCQHGRCISPEKCKCDHGYG 124
            ..||  :.|.|..      ||||     ...|:..    :|.|...|:.. .:.|:.|.   |:.
Mouse    65 GYIK--ITNGTVG------VRDCRYSLKIQSYVLD----IPGCRHICRKD-YLQPQCCP---GHW 113

  Fly   125 GPACDINCPPGWYGRNCSMQCDCLNNAVCE---PFSGDCECAKGYTGARCADICPEGFFGANCSE 186
            ||.| :.||.|       .:..|....||:   ..:|.|.|..|:.|..|.:...|..||.|||.
Mouse   114 GPDC-MECPGG-------ARAPCGGRGVCDEGMEGTGSCSCRAGFRGTACENCAAEDVFGPNCSA 170

  Fly   187 KCRCENGGKCHHVSGE--CQCAPGFTGPLCD--------MRCPDGKHGAQCQQD-----CPC--- 233
            .|.|.:|.....:||:  |:|...:.||.||        :.||:....:...:|     |.|
Mouse   171 VCSCVHGVCNSGISGDGTCECLSAYRGPRCDKPIPECAALLCPENSRCSPSSKDETKLQCKCLPS 235

  Fly   234 -QNDGK------------CQPETG---------ACMCNPGWTGD--VCA---------NKCPVGS 265
             :.||:            |.|...         :|:|..|:.||  ||.         ..||..|
Mouse   236 YKGDGQTCKPINPCLKNVCHPHASCSYLGPNRHSCVCQKGYQGDGQVCLPVDPCQTSYGNCPTKS 300

  Fly   266 Y-----GPG-----CQES---------------CE----CYKGAPCHHIT---GQCECPPGYRGE 298
            .     |||     |:|.               ||    |:|.|.|..::   .||.|..||.|:
Mouse   301 TVCRYDGPGQSHCECKEHYRNFVPGVGCSMTDICESKNPCHKNANCSTVSPGQTQCTCQKGYVGD 365

  Fly   299 --RCFDEC-----QLN--------------------TYGFNCS---------------------- 314
              .|:...     :||                    ||.:..|
Mouse   366 GLNCYGNIMQRLRELNTEPRGMWQGQLTSFISILDRTYAWPLSNLGPFTVLLPSDKGLKGVDVKE 430

  Fly   315 --MTCDCAN-------------------------------------------------------- 321
              |..:.|.
Mouse   431 LLMDKEAARYFVKLHIIAGQMSTEQMYNLDTFYTLTGKSGEIINKDKDNQLKLKLYGSKIVQIIQ 495

  Fly   322 -------------DAMCDRANGTCICNPGWT---------------------------------- 339
                         |...|:...|...||..|
Mouse   496 GNIVASNGLVHILDRAMDKIEPTLESNPQQTIMTMLQPRYGKFRSLLEKTNVGQALEKGGIDEPY 560

  Fly   340 ----------------------GAKCAERICE--------------------------------- 349
                                  ..:.:.::.|
Mouse   561 TIFVPSNEALSNMTAGVLDYLLSPEGSRKLLELVRYHIVAFTQLEVATLVSTLHIRSMANQIITF 625

  Fly   350 ---------ANKYGLD------------------------------CNR--------TC-ECDME 366
                     ||...:|                              ||.        || .|.|:
Mouse   626 NISSKGQILANNVAVDETEVAAKNGRIYTLTGVLIPPSILPILPHRCNETKREMKLGTCVRCFMK 690

  Fly   367 HTDLCHPE-------TGNC-QCSIGWS-SAQCTRPCTFLRYGPNCELTCNCKN--GAKCSPV--- 417
            :...|...       |..| ..|..|: ...|.|.|......|.|     ||.  |..|:|.
Mouse   691 NWSKCPTNSEPTAIFTNKCFYGSRAWNLKIGCARYCDVTVEIPRC-----CKGFFGPDCNPCPGG 750

  Fly   418 -----------------NGTCLCAPGWRGPTCEESCEPGTFGQDCALRCDCQNGAKCE---PETG 462
                             ||||:|..|::|..|:...:|..:|..|...|.|.:|. |:   ...|
Mouse   751 FMNPCSGNGQCIDGLGGNGTCICEDGFQGSRCQFCSKPNRYGPQCNRTCQCVHGI-CDNRLDSDG 814

  Fly   463 QCL---CTAGWKNIKCDRPCDLNHFGQDCAKVCD-CHNNAACNPQN--GSCTCAAGWTGE--RCE 519
            .||   |..|.....||:....      |..... ||.:|.|...|  .||.|..|:.|:  .|.
Mouse   815 SCLPGTCREGTAGRFCDKQTSA------CGPYMQFCHIHATCEYSNETASCVCNDGYEGDGTLCS 873

  Fly   520 RK--C--DTGKFGHDCAQKCQCDFNNSLACDATNG--RCVCKQDW------------------GG 560
            :|  |  .|.:.|  |:...:|       ..|:.|  .|||::.|                  ||
Mouse   874 KKDPCLGSTSRGG--CSPNAEC-------IQASTGTYSCVCQRGWTGNGRDCVEINSCLLPSSGG 929

  Fly   561 VH----C--------ETNCRSGYYGE--NCDKVCRCLNN-SSCDP-------DSG--NCICSAGW 601
            .|    |        |..|:.|:.|.  :|:.:..||.. ..|.|       .||  :|:|..|:
Mouse   930 CHDNATCLYVGPGQNECECKKGFRGNGIDCEPIISCLEQIEKCHPLATCQYTLSGVWSCVCQEGY 994

  Fly   602 TG--------------------------------------------------------------- 603
            .|
Mouse   995 EGNGVLCYGNVLMELSFLSEAAVFYQWINNASLQSMLSATSNLTVLVPSLQAIKDMDQNEKSFWL 1059

  Fly   604 ----------------------------------------------------------------- 603
                                                                             
Mouse  1060 SRNNIPALIKYHTLLGTYRVADLQTLPSSHMLATSLQGSFLRLDKADGNITIEGASFVDGDNAAT 1124

  Fly   604 ----------------------------------------------------ADCAEPCPP---- 612
                                                                ||......|
Mouse  1125 NGVVHIINKVLIPQRGLTGSLPSLLTRLEQMPDYSIFRGYIIHYNLASAIEAADAYTVFVPNNEA 1189

  Fly   613 -------------------------------------------GF-------------------- 614
                                                       ||
Mouse  1190 IESYIREKKATSLKEDILQYHVVLGEKLLRNDLHNGMHRETMLGFSYLLAFFLHNDQLYVNEAPI 1254

  Fly   615 ------------YGME-----CKERCPE----ILHGNKSCDHITGEILC---------------- 642
                        :|:|     .|.||..    |:.|  .|...:.:.||
Mouse  1255 NYTNVATDKGVIHGLEKVLEIKKNRCDNNDTIIVRG--KCGKCSQQTLCPLETKPLSETRKCIYS 1317

  Fly   643 ------RTGYIG--LTC-----EHPCPAGLYGPGCKLKCN------CEHGGEC---NHVTGQCQC 685
                  |:.:||  |.|     ...|.||.:||.|: .|.      |...|.|   .:.||.|:|
Mouse  1318 VYFMGKRSIFIGCQLQCVRTIITSACCAGFFGPQCQ-ACPGKGQNVCSGNGFCLDGVNGTGTCEC 1381

  Fly   686 LPGWTGSNCNESCPTDTYGQGCAQRCRCVHHKVCRK---ADGMCICETGWSGTRCD-EV------ 740
            ..|:.|:.| |:|....||..|.|.|.|||.: |.:   .||.|.|:.||.|.:|| |:
Mouse  1382 EQGFNGTAC-ETCTEGKYGIHCDQACSCVHGR-CNQGPSGDGSCDCDVGWRGVKCDSEITTDNCN 1444

  Fly   741 --------------------CPEGFYGEH--CMNTCACPSANFQCHA----------AHGCVCRS 773
                                |..||.|..  |....||..:|..|.|          :..|||::
Mouse  1445 GTCHTSANCLLDPDGKASCKCAAGFQGNGTVCTAINACEISNGGCSAKADCKRTIPGSRVCVCKA 1509

  Fly   774 GYTGD---------------NCDELIASQRIADQSENSSRASVALTL--------VLMTLFACII 815
            |||||               .||      |.|:.::.....:|...|        |...:..|:.
Mouse  1510 GYTGDGIVCLEINPCLENHGGCD------RHAECTQTGPNQAVCNCLPKYTGDGKVCTLINVCLT 1568

  Fly   816 ----FAVFIYYRRRVSNLKTEIAHVHYTHD------TNPPSWPPNHNFDNPVYGMQAE------- 863
                .:.|.:......:.:|......||.|      :.....|.|.:.....:.:|..
Mouse  1569 NNGGCSPFAFCNHTEQDQRTCTCKPDYTGDGIVCRGSIHSELPKNPSTSQYFFQLQEHAVQELAG 1633

  Fly   864 ----TRLLPN----NMRSKMNNFDQRSTMSTDYGDDCNASGRVGSYSINYNHDLLTKNL 914
                |..:|:    |..||:..:|::..||           ::..|.:.....||.:||
Mouse  1634 PGPFTVFVPSSDSFNSESKLKVWDKQGLMS-----------QILRYHVVACQQLLLENL 1681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	26..92	CDD:462204	18/71 (25%)
		EGF_CA	274..319	CDD:473889	19/102 (19%)
		gliding_CglD	<451..579	CDD:468178	43/176 (24%)
		DSL	567..609	CDD:473190	16/233 (7%)
Stab2	NP_619614.1	EGF_3	254..283	CDD:463759	7/28 (25%)
		EGF_3	334..369	CDD:463759	12/34 (35%)
		Fasciclin	390..512	CDD:396845	6/121 (5%)
		Fasciclin	533..661	CDD:396845	4/127 (3%)
		EGF_3	844..872	CDD:463759	10/27 (37%)
		EGF_3	881..916	CDD:463759	10/43 (23%)
		EGF_3	927..959	CDD:463759	8/31 (26%)
		EGF_3	965..1001	CDD:463759	10/35 (29%)
		Fasciclin	1018..1137	CDD:396845	0/118 (0%)
		Fasciclin	1156..1273	CDD:396845	7/116 (6%)
		EGF_3	1482..1518	CDD:463759	12/35 (34%)
		EGF_3	1524..1560	CDD:463759	6/41 (15%)
		EGF_3	1566..1602	CDD:463759	6/35 (17%)
		Fasciclin	1628..1733	CDD:396845	13/65 (20%)
		Fasciclin	1758..1889	CDD:396845
		Laminin_EGF	1978..2022	CDD:395007
		EGF_3	2094..2129	CDD:463759
		EGF_3	2135..2172	CDD:463759
		Link_Domain	2206..2297	CDD:470631
		FAS1	2363..2452	CDD:214719
		Interaction with TMSB4X. /evidence=ECO:0000250	2510..2520
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2514..2559