DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drpr and Stab1

DIOPT Version :9

Sequence 1:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	NP_619613.2	Gene:	Stab1 / 192187	MGIID:	2178742	Length:	2571	Species:	Mus musculus

Alignment Length:	1249	Identity:	269/1249 - (21%)
Similarity:	356/1249 - (28%)	Gaps:	552/1249 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 HCSEPCQH----GRCISPEKCKCDHGYGGPACDINCPPGWYGRNCSMQCDCLNNAVCEP------ 155
            ||.|. ||    |.|:                               .|..||.:||.|
Mouse   654 HCDEE-QHQTVLGSCV-------------------------------DCQALNTSVCPPNSVKMD 686

  Fly   156 -FSGDCECAKGYTGAR-----CADICPE---------GFFGANCSEKC------RCENGGKCH-- 197
             |..:|.......|..     |||.|.:         ||||.:|:: |      .|...|.|.
Mouse   687 IFPKECVYIHDPNGLNVLKKGCADYCNQTITKRGCCKGFFGPDCTQ-CPGGFSNPCYGKGNCSDG 750

  Fly   198 -HVSGECQCAPGFTGPLCDMRCPDGKHGAQCQQDCPCQNDGKCQPETGACMCNPGWTGDVC-ANK 260
             ..:|.|.|.|.:.|..|.:.....|||.|||:||.|.:        |.|...|| :|.|| ...
Mouse   751 VRGNGACLCFPDYKGIACHICSDPKKHGEQCQEDCGCVH--------GLCDNRPG-SGGVCQQGT 806

  Fly   261 CPVGSYGPGCQESC-ECYK---GAPCH---HI-----TGQCECPPGYRGERCFDECQLNTYGFNC 313
            |..|..|..|.||. .|..   ..|||   |.     ..:|.|..|:.|.           ||:|
Mouse   807 CAPGFQGRFCNESMGNCGSTGLAQPCHSDAHCVIQEGVARCVCHDGFEGN-----------GFSC 860

  Fly   314 --SMTCD------CANDAMC---DRANGTCICNPGWTGAKCAERICEA-NKYGLDCNRTCECDME 366
              |..|.      |:.:|.|   |.....|||:.||:|   ..|||.| ::.|||....|..|.
Mouse   861 KRSNPCSRPDRGGCSENAECVPGDLGTHHCICHKGWSG---DGRICVAIDECGLDTRGGCHADA- 921

  Fly   367 HTDLCH---PETGNCQCSIGW--SSAQCT--RPCTFLRYGPNCELTCNCKNGAKCSPVNG---TC 421
               ||.   |....|.|.:|:  :..:|:  .||   |.|..     .|...|.|..|.|   .|
Mouse   922 ---LCSYVGPGQSRCTCKLGFAGNGYECSPIDPC---RVGNG-----GCHGLATCKAVGGGQRVC 975

  Fly   422 LCAP--GWRGPTC--------EESCEPGTFGQ-------------------------------DC 445
            .|.|  |..|.:|        |.:.....|.|                               |.
Mouse   976 TCPPHFGGDGFSCYGDIIQELEANAHFSAFSQWFKNSSITLPADSRVTALVPSESAIRRLSLEDQ 1040

  Fly   446 AL-----------RCDCQNGAKCEPE----TGQCLCTAG--------------W-KNIKCDRPCD 480
            |.           |.....||..|.|    .||.:.|..              | :|...|.| |
Mouse  1041 AFWLQPKMLPELARAHFLQGAFSEEELARLNGQQVATLSATTRWQIHNISGKVWVQNATVDVP-D 1104

  Fly   481 L-------------------------------------NHFGQ-----------DCAKVCDC--- 494
            |                                     ..||:           :.||....
Mouse  1105 LLATNGILHIVSQVLLPPRGDMQTGPGLLQQLDSVPAFRLFGEQLKHHKLVAQIEAAKAYTIFVP 1169

  Fly   495 --------------------------------------HNNAACNPQN----------------- 504
                                                  |.|:...|.:
Mouse  1170 TNHSLETQGNNSVLGIDTVRHHVILGEALSVEVLRKGGHRNSLLGPAHWLVFYNHSGQPEVNHMP 1234

  Fly   505 ----------------------GSCTCAAGWTGERCERKCDTGKFGHDCAQKCQCDFNNSLACDA 547
                                  ||..|... ..|....||      .:|.:|.:|.....|. |.
Mouse  1235 LEGPLLEAPGSSLFGLSGILAVGSSRCLHS-HAEALREKC------INCTRKFRCTQGFQLQ-DT 1291

  Fly   548 TNGRCVCKQDWGGVHCETNCRSGY-YGENCDKVCRCLNNSSCDPDSGNCICSAGWTGADCAEPCP 611
            ....||             .|||. :...|...|.   .....||     |..|:.|..| ||||
Mouse  1292 PRKSCV-------------YRSGLSFSRGCSYTCA---KKIQVPD-----CCPGFFGTLC-EPCP 1334

  Fly   612 PGFYGM-----ECKERCPEILHGNKSCDHITGEILCRTGYIGLTCEHPCPAGLYGPGCKLKCNCE 671
            .|..|:     :|::|    ..||       ||..|:.|:.|..|| .|..|.|||.|...|:|:
Mouse  1335 GGLGGVCSGHGQCQDR----FLGN-------GECRCQEGFHGTACE-MCELGRYGPTCSGVCDCD 1387

  Fly   672 HG--GECNHVTGQCQCLPGWTGSNCNE-----SCPTDTYGQGCAQRCRCVHHKVCRKADGMCICE 729
            ||  .|.....|.|.|..||.|..|::     .||     :.|.....|:.......|   |:|.
Mouse  1388 HGLCQEGLRGNGSCVCHAGWQGLRCDQKITDHQCP-----KKCDPNANCIQDSAGIPA---CVCA 1444

  Fly   730 TGWS--GTRCDEV---------------------------CPEGFY--GEHCMNTCACPSANFQC 763
            .|:|  |:.|.||                           |.:|:.  ||.|....:|...|..|
Mouse  1445 AGYSGNGSYCSEVDPCASGHGGCSPYANCTKVAPGQRTCTCQDGYTGDGELCQEINSCLVHNGGC 1509

  Fly   764 HAAHGCV----------CRSGYTGD----------------------------------NCDELI 784
            |....|:          ||.||:||                                  :||
Mouse  1510 HVHAECIPTGPQQVSCSCREGYSGDGIQTCKLLDPCSQNNGGCSPYAVCKSTGDGQRTCSCD--- 1571

  Fly   785 ASQRIADQSENSSRASVALTLVLMTLFACII---------------FAVFIYYRRRVSNL-KTEI 833
            |:..:.|......|..:.|   |...:|...               |.||:.:...:||: :.|:
Mouse  1572 ATHTVGDGITCHGRVGLEL---LRNKYASFFSLHLLEYKELKGDGPFTVFVPHADLISNMSQDEL 1633

  Fly   834 AHVHYTHDTNPPSWPPNHN---FDNPVYGMQAETRLLPNNMRSKMNNFDQRSTMSTDYGDDCNAS 895
            |.:.            .|.   |...|.|.:   :|....|      .|| ..::|..|.....|
Mouse  1634 ARIR------------AHRQLVFRYHVVGCR---KLWSQEM------LDQ-GYITTLSGHTLRVS 1676

  Fly   896 GRVGSYSINYNHDLLTKNLNADRTNPIVYNESLKEEHVYD------EIKHKEGYKDPV------- 947
            .|.||..:|....:::.:|.       |.|..|   |..|      ::.|.|....|:
Mouse  1677 EREGSIYLNDFARVVSSDLE-------VVNGVL---HFIDHVLLPPDVLHWESGAIPIPQRNVTA 1731

  Fly   948 -------KIYSKIL 954
                   ||:|::|
Mouse  1732 AAESFGYKIFSRLL 1745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	27..92	CDD:284877
		EGF_CA	274..319	CDD:304395	14/64 (22%)
		DSL	<479..518	CDD:302925	13/166 (8%)
		DSL	<567..606	CDD:302925	10/39 (26%)
Stab1	NP_619613.2	Fasciclin	520..644	CDD:280607
		EGF_3	915..946	CDD:289699	8/34 (24%)
		EGF_3	952..988	CDD:289699	13/43 (30%)
		Fasciclin	1000..1121	CDD:280607	18/121 (15%)
		EGF_3	1460..1496	CDD:289699	4/35 (11%)
		EGF_3	1502..1539	CDD:289699	11/36 (31%)
		EGF_3	1545..1582	CDD:289699	4/39 (10%)
		Fasciclin	1607..1711	CDD:280607	28/135 (21%)
		Fasciclin	1737..1867	CDD:280607	4/9 (44%)
		EGF_Lam	<1992..2021	CDD:214543
		EGF_3	2095..2130	CDD:289699
		EGF_3	2136..2173	CDD:289699
		Link_Domain	2208..2300	CDD:295393
		FAS1	2367..2463	CDD:214719
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900