DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drpr and F48E3.8

DIOPT Version :9

Sequence 1:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	NP_001360756.1	Gene:	F48E3.8 / 181010	WormBaseID:	WBGene00018607	Length:	2111	Species:	Caenorhabditis elegans

Alignment Length:	1249	Identity:	273/1249 - (21%)
Similarity:	387/1249 - (30%)	Gaps:	462/1249 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VILIACLAQLVL---AQADLKDLDGP---NICKRRELYNVDVVYTELQSFQERGSTWCVTFPPRC 62
            :.|:..||:::|   ..||.:.::..   |..:||.       |...:::|......| ::..:|
Worm     4 LFLVFILAEIMLQNEIMADHRTINQSFRGNFFRRRN-------YDGPRAYQIAPDLTC-SYDNQC 60

  Fly    63 STYR----------IKHRVVNKTKTIAKNRIVRD---CCDG--YIASAGEC--VPHCSEPCQHG- 109
            :.|.          :|..:...|..||.:..::.   |..|  ||..||.|  |....||||:.
Worm    61 AGYPLAICHSVCQCVKGALNTGTTCIASSTAIQTSVACPAGQTYIREAGVCMTVQQPGEPCQYSQ 125

  Fly   110 RCISPE------KCKCDHGYGGPACDINC-------------------------PPGWYGRNCSM 143
            :|.:.|      |.:|:..||.......|                         |||  |:.||.
Worm   126 QCSALEPGAYCLKMRCECVYGMKKSSNGCTFVNNDCKERGHIFISEIGECREVFPPG--GKGCSH 188

  Fly   144 QCDCLN---NAVCEPFSGDCECAKGYTGA---RCADICPEGFFGANCSEKCRCEN--GGKCHHVS 200
            ...|..   :|.|  |...|.|......|   .|...||.....:..:.:|..|.  |..|.:.|
Worm   189 NLQCSGAYPDATC--FMQTCTCPPNLPVAADGTCGRSCPNNQVYSGVTGECLPEKQPGQDCIYSS 251

  Fly   201 GECQCAPGFTGPLCD---MRCPDGK--HGAQCQQDCP--------------CQND-----GKC-- 239
               ||...|.|.:||   .|||:|.  .|.:|...||              |.:.     |:|
Worm   252 ---QCQASFGGLVCDKNTCRCPNGLVFDGLKCSHGCPPHKRVIDKEICVEGCPSGIVEVAGRCVK 313

  Fly   240 -----QPETGACMCNPGWTGDVCAN---KCPVGSY-------------GPGCQESCECYKGAPCH 283
                 ||......||   .|..|.:   :||.|.|             ...||.:.:|.||:.|:
Worm   314 QVSIGQPCVANAQCN---FGSFCQSGTCQCPPGFYVQDEQCQAIESEPNESCQNNEKCTKGSVCY 375

  Fly   284 HITGQCECPPGYRGERCFDECQLN---TYGFNCSM----------------------TCDCAND- 322
            :  |:|.||..:  |.....||.|   .:.:|.::                      ..|..||
Worm   376 N--GKCSCPRNH--ELINGHCQQNRAAAHAYNTALENIRKIRLRFASQSKSRNSSPQLTDVENDN 436

  Fly   323 -------------AMCDRAN----GTCICNPGWT--GAKCAERICEANKYGLDCNRTCECDMEHT 368
                         ..||..:    |.|:|..|.|  ...|.|.:  |.:.|..|....|| ::|:
Worm   437 DTVPIGSACVRIGVTCDGGSVCVAGICVCPLGKTPRNGVCIEHV--AARPGTSCQNEEEC-VDHS 498

  Fly   369 DLCHPETGNCQCS------IGWSSAQCTRPCTFLRYGPNCELTCNCKNGAKCSPVNGTCLCAPG- 426
             .|.|||..|:|.      ||   .:| |.......|..|.:...|...:.|  |||.|.|..|
Worm   499 -YCSPETNKCECMKASQMVIG---GEC-RERLKAHPGYGCTMGEMCVGNSVC--VNGKCACVDGK 556

  Fly   427 -WRGPTC--EESCEPGTFGQDCALRCDCQNGAKCEPETGQCLCTAGWKNIK--CD-----RPCDL 481
             .....|  :.|.:|   |..|.....|:.|:.|..::|:|.|..|..:|.  |.     .|.||
Worm   557 VEINKICIDQVSAKP---GDTCGKGIICEGGSYCNTDSGKCACRRGENSINGICKGFTFVYPGDL 618

  Fly   482 NHFGQDCAKVCD-CHNNAACNPQNGSCTCAAGWTGERCERKC---DTGKFGHDCAQKCQCD-FNN 541
                  |..:.. |...:.|  ..|.|.|....:.  .::||   .|...|..|::|..|. |:
Worm   619 ------CTDITSRCTGGSYC--ARGRCECPPRMSA--IDKKCVHQQTAAPGEPCSEKVACSPFS- 672

  Fly   542 SLACDATNGRCVCKQDWGGVHCETN-------C---RSGYYGENCDKVCRCLNNSSCDPDSGNCI 596
              .|:..    |||       |..|       |   |....|.:|:...:||.||:|  ...||.
Worm   673 --VCENN----VCK-------CVNNMMIRDKMCVQRRKVNIGNSCNNEDQCLGNSTC--MDNNCQ 722

  Fly   597 CSAGWTGADCAEPC------PPGFYGMECKERCPE-ILHGNKSCDHITGEILCRTGY-------- 646
            |..|:..:  .:.|      .||:.   |.   || |..|...|  |.|...|:..|
Worm   723 CGIGFVAS--MDVCVLRKTVTPGYL---CN---PEDICTGQSVC--IKGVCQCQPDYKQMHNICV 777

  Fly   647 ------------------IGLTC----EHPCPAGLYGPGCKLKC------NCEHGGECNHVTGQC 683
                              .||.|    :..||.||:....|.:.      .|.....|.....||
Worm   778 KKNIGIEGSPCSSRDDCGEGLMCGASGKCSCPEGLFSVNGKCRSYVQLGQTCTSDDRCAERNAQC 842

  Fly   684 Q-----CLPGWTGSNCNESCPTD----------------TYGQGCAQRCRC-VHHKVCRKADGMC 726
            |     |..|:|  |.|..|..:                ..|..|.....| :.|..||:  .:|
Worm   843 QENYCTCRTGYT--NINGQCAANIVTPAEPETLSQVKSGLLGHICTSNDHCKIAHSQCRR--NVC 903

  Fly   727 ICETGWS----------------------------GTRCDEV---------------CPEGFY-- 746
            .|..|:.                            |.:||::               |||.|:
Worm   904 QCIDGYRIFGSTQCIPRPGKPKERKTEKESKLVELGDKCDKLSLCSKGAICEKGVCSCPETFFES 968

  Fly   747 -----------------------GEHCMNTCACPSANFQCHAAHG-CVCRSGYT--GDNCDEL-- 783
                                   ||.|       |.|.:|  .|| |.|:..:|  ...|..|
Worm   969 DGACVKNVAKIKVVVPPLSSCLGGEEC-------SGNSEC--VHGICFCKEEFTLFEGKCQRLRI 1024

  Fly   784 ---------------IASQRIADQSENSSRASVALTLVLMTLFACIIFAVFIYYRRRVSNLKTEI 833
                           |.:......:.|::...|..|..|.|..|                  |.:
Worm  1025 IEKLTVLESKKLIKPIKAHTTPTAASNTTPIPVKTTTTLQTTTA------------------TTL 1071

  Fly   834 AHVHYTHDTNPP-------------SWPPNHNFDNPVY-------GMQAETRLLPNNMRSKMNNF 878
            ...:.:..||.|             |.|......||.|       |...:.:....|....:|.|
Worm  1072 PENYVSSSTNRPLTPIIISMKLGSTSSPSPQITSNPEYKWRLSKPGHMCDNKTHCTNCSVCVNGF 1136

  Fly   879 DQRSTMSTDYGDDC 892
            .:.......|||.|
Worm  1137 CRCPEGLVHYGDKC 1150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	27..92	CDD:284877	14/79 (18%)
		EGF_CA	274..319	CDD:304395	13/69 (19%)
		DSL	<479..518	CDD:302925	8/39 (21%)
		DSL	<567..606	CDD:302925	13/41 (32%)
F48E3.8	NP_001360756.1	EB	98..154	CDD:366756	18/55 (33%)
		EB	224..280	CDD:366756	18/58 (31%)
		EB	300..351	CDD:366756	13/53 (25%)
		EB	340..392	CDD:366756	15/55 (27%)
		EB	<438..476	CDD:366756	7/37 (19%)
		EB	514..563	CDD:366756	14/54 (26%)
		EB	552..607	CDD:366756	15/57 (26%)
		EB	596..650	CDD:366756	13/63 (21%)
		EB	639..692	CDD:366756	15/68 (22%)
		EB	681..734	CDD:366756	15/56 (27%)
		EB	723..776	CDD:366756	15/62 (24%)
		EB	808..860	CDD:366756	15/53 (28%)
		EB	961..1019	CDD:366756	15/66 (23%)
		EB	<1111..1150	CDD:366756	7/38 (18%)
		EB	1283..1340	CDD:366756
		EB	1413..1473	CDD:366756
		EB	1462..1517	CDD:366756
		EB	1757..1812	CDD:366756
		EB	<1893..1930	CDD:366756
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000