DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment drpr and D1044.7

DIOPT Version :9

Sequence 1:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	NP_498177.1	Gene:	D1044.7 / 175758	WormBaseID:	WBGene00017032	Length:	400	Species:	Caenorhabditis elegans

Alignment Length:	483	Identity:	110/483 - (22%)
Similarity:	149/483 - (30%)	Gaps:	180/483 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 CPPGWY----GRNCSMQCDCLNNAVCEPFSGDCECAKGYTGARCADICPEGFFGANCSEKCRCEN 192
            ||||..    ..|.:....|.....|..||         ..||         :||.|.......|
Worm    19 CPPGLIPLTSNNNFNQPLTCTPQDPCSCFS---------VSAR---------YGAICHYSSNYNN 65

  Fly   193 GGKCHHVSGEC------------QCAPGFTGPLCDMRCPDGKHGAQCQQDCPCQNDGKCQPETGA 245
            ...||..:.:|            |....||             .:||.....|.| |.|.|.|.:
Worm    66 YLCCHSQNTQCGTNSSPQVSASGQVVTCFT-------------NSQCASGYICSN-GACCPNTNS 116

  Fly   246 CMCN----PGWTGDV-----CANKCPVGSYGPGCQESCECYKGAPCHHITGQCECPPGYR--GER 299
            ..|:    |.:||.:     |.|...:|.   .||.|.:|..|:.|.:  ..|:||.|:.  .::
Worm   117 NTCSTTGTPCFTGQISVGGQCFNSVNIGD---RCQRSEQCLGGSQCQN--NLCQCPNGFANVNQK 176

  Fly   300 CFDECQLNTY------------GFNCSMTCDCANDAMCDRANGTCICNPGWTGAKCAERICEANK 352
            |  .|||.|.            |.||.::..|.::::|:  |..|.||..:       |:.
Worm   177 C--ACQLGTVLFNSQCITLASPGQNCQISSQCIDNSVCN--NQMCSCNGNY-------RLV---- 226

  Fly   353 YGLDCNRTCECDMEHTDLCHPETGNCQCSIGWSSAQCTRPCTFLR-YGPNCELTCNCKNGAKCSP 416
            :|               .|.|.| |.:|.  .:.......|..|. .|..|.....|..||.|:
Worm   227 FG---------------YCVPFT-NSKCQ--QTQTLVNNQCVLLSIVGETCIANQQCVGGAMCN- 272

  Fly   417 VNGTCLCAPGWRGPTCEESCEPGTFGQDCALRCDCQNGAKCEPETGQCLCTAGWKNIKCDRPCDL 481
             :|||.|.                            |||..  ..|.|:.:....|     ||:.
Worm   273 -SGTCRCT----------------------------NGATA--MYGYCISSQSTVN-----PCNS 301

  Fly   482 N------------HFGQDCAKVCDCHNNAACNPQNGSCTCAAGW-------TGERCERKCDTGKF 527
            |            :.|..|.....|..|:.|  ||..|.|.:|.       |.......|.:|
Worm   302 NQVYYNGQCYNTVNIGFQCQITQQCLGNSQC--QNSFCQCTSGSPNNGICPTSPNTSNLCSSG-- 362

  Fly   528 GHDCAQKCQCDFNNS-LACDATNGRCVC 554
                 |..|.|.||. :.|..|    ||
Worm   363 -----QTVQLDNNNQPINCLVT----VC 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	27..92	CDD:284877
		EGF_CA	274..319	CDD:304395	15/58 (26%)
		DSL	<479..518	CDD:302925	13/57 (23%)
		DSL	<567..606	CDD:302925
D1044.7	NP_498177.1	EB	126..177	CDD:279949	15/55 (27%)
		EB	179..230	CDD:279949	15/78 (19%)
		EB	238..289	CDD:279949	17/84 (20%)
		EB	299..349	CDD:279949	12/51 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D561378at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910