DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment drpr and Kit

DIOPT Version :9

Sequence 1:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	NP_001116205.1	Gene:	Kit / 16590	MGIID:	96677	Length:	979	Species:	Mus musculus

Alignment Length:	204	Identity:	42/204 - (20%)
Similarity:	70/204 - (34%)	Gaps:	71/204 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   869 NNMRSKMN-------------------NFDQRSTM--STDYGDD-----CNASGRVGSYSINYNH 907
            |:|..|||                   |::::.|:  |:...||     |.|:...||.::....
Mouse   244 NSMWLKMNPQPQHIAQVKHNSWHRGDFNYERQETLTISSARVDDSGVFMCYANNTFGSANVTTTL 308

  Fly   908 DLLTK---NLNADRTNPIVYNESLKEEHVYDEIKHKEGYKDPVKIYSKILFPEDEYDHLDYSRPS 969
            .::.|   |::..:...:...:.   |:| |.:...|.|            |:.|:....|
Mouse   309 KVVEKGFINISPVKNTTVFVTDG---ENV-DLVVEYEAY------------PKPEHQQWIY---- 353

  Fly   970 TSQKPHYHRMNDAMLNINQD---EEKPSNVKNMTVLLNKPLPPTEPEPQHECFDNTNTNLDNVST 1031
                     ||....|..:|   .:..||::.:..|....|..||        ..|.|.|  ||.
Mouse   354 ---------MNRTSANKGKDYVKSDNKSNIRYVNQLRLTRLKGTE--------GGTYTFL--VSN 399

  Fly  1032 ASPSSSPKF 1040
            :..|:|..|
Mouse   400 SDASASVTF 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	27..92	CDD:284877
		EGF_CA	274..319	CDD:304395
		DSL	<479..518	CDD:302925
		DSL	<567..606	CDD:302925
Kit	NP_001116205.1	ig	217..308	CDD:278476	14/63 (22%)
		IG_like	221..310	CDD:214653	14/65 (22%)
		Ig4_SCFR	314..414	CDD:143268	27/134 (20%)
		IG_like	325..412	CDD:214653	26/123 (21%)
		Ig	427..501	CDD:299845
		PTKc_Kit	556..930	CDD:270682
		Important for interaction with phosphotyrosine-binding proteins. /evidence=ECO:0000250	571..573
		Pkinase_Tyr	592..926	CDD:285015
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900