DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drpr and pear1

DIOPT Version :9

Sequence 1:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	XP_017952446.2	Gene:	pear1 / 100489801	XenbaseID:	XB-GENE-6045593	Length:	1087	Species:	Xenopus tropicalis

Alignment Length:	1104	Identity:	361/1104 - (32%)
Similarity:	516/1104 - (46%)	Gaps:	135/1104 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLPVILIACLAQLVLAQADLKDLDGPNICKRRELYNVDVVYTELQSFQERG-----STWCVTFPP 60
            |:|::.:  |.|:...:: |...| ||:|...|.:.:.|..:..|.:.:..     |:|  .:..
Frog     7 MIPIVWM--LVQIQFGKS-LSPND-PNVCSFWESFTLAVKESYTQPYSQLSPDSCDSSW--NYFK 65

  Fly    61 RCSTYRIKHRVVNKTKTIAKNRIVRD------CCDGYIASAGECVPHCSEPCQHGRCISPEKCKC 119
            .|:..:|.:|      |..::|:..|      ||.||..|...|||.|::.|.|||||:|::|:|
Frog    66 ACTPQKILYR------TAYRHRVKLDYRRRYWCCKGYYESNDICVPRCTQECVHGRCIAPDQCQC 124

  Fly   120 DHGYGGPACDINCPPGWYGRNCSMQCDCLNNAVCEPFSGDCECAKGYTGARCADICPEGFFGANC 184
            :.|:.|..|...|....:|..|:..|.|.||..|:..||.|.|..|:....|...|..|.:|..|
Frog   125 EPGWRGKDCSSACEAHVWGPKCNSTCPCQNNGACDAASGTCICPPGFRDPFCEKPCDPGTYGGGC 189

  Fly   185 SEKCRCENGGKCHHVSGECQCAPGFTGPLCDMRCPDGK-HGAQCQQDCPCQNDGKCQPETGACMC 248
            |..|:|:||.:|...:|.|.|..|:|||.|::||.:.: ....|...|.||:.|.|...:|.|.|
Frog   190 SLSCQCKNGAECDPENGACLCPEGYTGPYCEIRCKEVQPANFSCSDQCLCQSGGICNQSSGECSC 254

  Fly   249 NPGWTGDVCANKCPVGSYGPGCQESCECYKGAPCHHITGQCECPPGYRGERCFDECQLNTYGFNC 313
            .|||.|.:|:..||.|.||..|::.|.|:.|..|...||||.|..||.|:.|.:||.:..||.:|
Frog   255 PPGWMGSLCSIPCPDGYYGRNCKQECLCHNGGQCDPKTGQCLCSEGYTGDHCREECPIGKYGKDC 319

  Fly   314 SMTCDCANDAMCDRANGTCICNPGWTGAKCAERICEANKYGLDCNRTCECDMEHTDLCHPETGNC 378
            |..|||.|...|...||.|:|..|:.|..|.||:|....||:.||..|.||..|:..|||.:|.|
Frog   320 SEKCDCINAVRCYHINGGCLCEHGFKGEACDERMCPPGLYGMPCNLRCLCDPLHSQSCHPMSGEC 384

  Fly   379 QCSIGWSSAQCTRPCTFLRYGPNCELTCNCKNGAKCSPVNGTCLCAPGWRGPTCEESCEPGTFGQ 443
            .|..|||...|...|....||.||:..|.|.||..|....|.|:||||:.||.|...|...|:|.
Frog   385 ACKPGWSGLYCNETCPHGYYGTNCQELCVCLNGGSCDSETGECICAPGFTGPQCSSYCPMETYGP 449

  Fly   444 DCALRCDCQNGAKCEPETGQCLCTAGWKNIKCDRPCDLNHFGQDCAKVCDCHNNAACNPQNGSCT 508
            .|:.:|.|:|...|.|..|.|:|..||:...|..||....:|.:|.:.|:|:|.|:|:|.:|.|:
Frog   450 KCSQKCGCKNSLACSPIDGSCVCKEGWQKGDCSVPCPKGTWGYNCNRTCECNNGASCSPISGLCS 514

  Fly   509 CAAGWTGERCERKCDTGKFGHDCAQKCQCDFNNSLACDATNGRCVCKQDWGGVHCETNCRSGYYG 573
            |.:||.|::||:.|..|.||..|.|:|:|:  ||..||...|:|.|...|.|..|:.:|..|::|
Frog   515 CTSGWHGDKCEQPCKDGTFGPGCRQQCECE--NSDNCDPITGQCWCLPGWTGPECKQSCEEGFWG 577

  Fly   574 ENCDKVCRCLNNSSCDPDSGNCICSAGWTGADCAEPCPPGFYGMECKERCPEILHGNKSCDHITG 638
            ..|:..|.|.|.:||.|..|.|.|:||:.|.||...||.|.||.:|...|.  ...:.:|:||.|
Frog   578 RKCNMTCDCKNGASCSPKDGTCTCAAGFRGPDCDNICPHGRYGKKCVLTCK--CSNHSTCNHIDG 640

  Fly   639 EILCRTGYIGLTCEHPCPAGLYGPGCKLKCNCEHGGECNHVTGQCQCLPGWTGSNCNESCPTDTY 703
            ...|..|:.|..|..||..|.:|..|...|||:|||.|:...|.|.|..||||..|:|.||..:|
Frog   641 SCKCFPGWKGNDCSEPCTLGFWGKDCASTCNCQHGGHCSPTDGTCICPIGWTGKTCSEVCPLGSY 705

  Fly   704 GQGCAQRCRCVHHKVCRKADGMCICETGWSGTRCDEVCPEGFYGEHCMNTCACPSANFQCHAAHG 768
            |:.|..:|||.:...|....|.|.|..|:.|..|:..||:..||..|...|.|.: |..||...|
Frog   706 GENCIHKCRCQNGAECDHMTGKCSCLPGYHGAFCEIKCPDRTYGLKCHQVCECLN-NATCHHVTG 769

  Fly   769 -CVCRSGYTGDNCDELIASQRIADQSENSSRASVA----LTLVLMTLFACIIFAVFIYYRRRVSN 828
             |.|.:.:.|.:|::.:..:.......|:..|:.:    :.:|.:.:...::...|:|||....:
Frog   770 SCQCEAAWFGVHCEKSLNVEVPFTMVPNTPPATDSIGPIIGIVALAILVVVLIGFFLYYRHWQKD 834

  Fly   829 LKTEIAHVHYTHDTNP-------PSWPP---NHNFDNPVYGMQAETRLLPNNMRSK--------- 874
            ..|....|.|: .|.|       |..||   .|.:.||.|...::....|..:.||
Frog   835 KVTRSLTVAYS-PTRPASSVYEVPDVPPVGYLHYYSNPSYHTLSQCGPCPPPVPSKPERPNSVKM 898

  Fly   875 --MNNF----------------DQRSTMSTDY-------------GDDCNASGRVGSYSINYNHD 908
              ..:|                |..:|:..|:             |...:.|..||.|....||.
Frog   899 AGKGHFPKVKHPDRERIGGYGTDYNATLPADWKHHGVPLNPRDMGGHRIDRSYSVGVYYNKANHY 963

  Fly   909 LLTKNLNADRTNPIVYNESLKEEHVYDEIKH--------KEG----YKDPV---KIYSKI-LFPE 957
            :....|:..       :.||..|:.|..||.        .||    .|.||   ..|::| ||.|
Frog   964 VKDSGLSTS-------SSSLNSENPYATIKDFPTLPGKLTEGSYMEMKSPVHREMSYAEIGLFDE 1021

  Fly   958 D-EYDHLDYSRPSTSQKPHYHRMNDAMLNINQDEEKPSNVKNMTVLLNKPLPPT----EPEPQH 1016
            | :|..                      ::.::|..|...:.:|.:....:|||    .|:..|
Frog  1022 DAQYQQ----------------------DLMEEENFPLGAEGVTTIHRNSVPPTSHYDSPKNSH 1063

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	27..92	CDD:284877	16/75 (21%)
		EGF_CA	274..319	CDD:304395	20/44 (45%)
		DSL	<479..518	CDD:302925	15/38 (39%)
		DSL	<567..606	CDD:302925	16/38 (42%)
pear1	XP_017952446.2	EMI	29..97	CDD:400092	16/75 (21%)
		exchanger_TraA	<147..>310	CDD:411343	64/162 (40%)
		exchanger_TraA	<416..729	CDD:411343	127/316 (40%)
		Laminin_EGF	546..586	CDD:395007	14/39 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9445
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	802	1.000	Inparanoid score	I491
OMA	1	1.010	-	-		QHG47996
OrthoDB	1	1.010	-	-		D34806at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48077
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1195
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.980