DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment drpr and dkk3b

DIOPT Version :9

Sequence 1:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	NP_001083014.1	Gene:	dkk3b / 100038765	ZFINID:	ZDB-GENE-061207-74	Length:	283	Species:	Danio rerio

Alignment Length:	196	Identity:	48/196 - (24%)
Similarity:	61/196 - (31%)	Gaps:	59/196 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 RIKHRVVNKT------KTIAKN-----------RIVRDCCDG----YIASAGECVPHCSEPCQ-- 107
            ||..:..|||      :|:.:|           .|..||.||    |.....:||     |||
Zfish   105 RINKKTDNKTGKTHFSRTLIQNTERWNEVDHECMIDEDCGDGSFCLYEIVTSKCV-----PCQTT 164

  Fly   108 HGRCISPEKCKCDHGYGGPACDINCPPGWYGRNCSMQCDCLNNAVCEPFSGDCECAKGYTGARCA 172
            :..|....:|..|.......|..|...|..|..|..|.||.....|           .:..|...
Zfish   165 NMECTKDVECCGDQLCVWGVCAQNKTKGQSGTICQNQNDCSPQHCC-----------AFHKALLF 218

  Fly   173 DIC-PEGFFGANCS-------EKCRCENGGKCHHVSGECQCAPGFTGPLCDM-----RCPDGKHG 224
            .:| |:...|..|.       |....|:.|...|    |.||.|.   ||..     .|.|.:|.
Zfish   219 PVCRPKPQEGQGCEREGNQLMEVLLWEDEGPREH----CPCAAGL---LCQQIQKSSVCVDERHA 276

  Fly   225 A 225
            :
Zfish   277 S 277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drpr	NP_001261276.1	EMI	27..92	CDD:284877	12/46 (26%)
		EGF_CA	274..319	CDD:304395
		DSL	<479..518	CDD:302925
		DSL	<567..606	CDD:302925
dkk3b	NP_001083014.1	Dickkopf_N	137..186	CDD:282549	14/53 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900