DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18171 and CG14325

DIOPT Version :9

Sequence 1:	NP_647651.1	Gene:	CG18171 / 38216	FlyBaseID:	FBgn0035262	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_650641.2	Gene:	CG14325 / 42123	FlyBaseID:	FBgn0038531	Length:	460	Species:	Drosophila melanogaster

Alignment Length:	416	Identity:	87/416 - (20%)
Similarity:	152/416 - (36%)	Gaps:	94/416 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 SDDEDDSGNERRKRRH-----------ERNVARQRLRDLKAAREAEHEERRRRRSEMRKPKEPEP 313
            |:|::|..|:.:..||           |..:.||..|         .|:|....|.:......:.
  Fly    43 SEDQEDQTNQAKSLRHLVLDSIVENWSELPLYRQLGR---------REDRNYLLSHLDTQLPLQL 98

  Fly   314 RKKKKRR----QRIKGTFDIRVEPEPDDGDDK----VLDKRNKQRYLTHLQQLKYPEDDCVHIDL 370
            .....|.    ||..| ...|..|....|.::    :..:|:.|.::.::....|.:|..|.:.|
  Fly    99 LSAHIREDFFWQRCYG-HRWRSAPLQARGRERPWINIYMERHVQEFIENMPTGDYEQDGNVQVVL 162

  Fly   371 SFVRHFVNLVSLNLEFLGPA---------------------------------LGRKYHKRNVLF 402
            .....::|  .|.:.||.||                                 :|..|.......
  Fly   163 DICAAYIN--QLEISFLQPAPPTTDANDHIPLDYLLSNLPDLRQLRLSYSTKTVGCNYQMGCNQL 225

  Fly   403 SIKDMVRLARGLVALQQLQIFRLRNSRLNSFKLYTV-------CRALRLLPLLE--VVDFGYNQM 458
            :::|::.|.:||....:|:.|.|.|::|..::|..:       |..|..:.||.  |.|.|....
  Fly   226 TVRDILHLTKGLSQCHELRTFCLHNTKLMPYQLRFLAHSLDKGCHHLTEMSLLHCAVGDAGIRCF 290

  Fly   459 TDDCGPE-LGILLERPQMLKILELEYNRLDTRAMSAIGEALQR-PNLSRLEYLGLAHNKLSGDSL 521
            .:.||.| .|       .|.:|:|..|::.......:...|:. |    ||.|.|..|.:..|..
  Fly   291 LETCGKESFG-------TLTVLDLTNNKITEEGAYILSRTLRHVP----LEKLVLRLNPIQSDGA 344

  Fly   522 SILCNGIKGTEHVEELNVS--GIEANPRTIVDQLGDLLRHHDPLRRLIMVAIPLGAKLGTRLICA 584
            :.:.|.:: ...::||::.  ||   ..||......|:..|..|..:.:....||...|..|:..
  Fly   345 AAIFNTLQ-VMPIKELDLGTCGI---TETITKLFMMLICQHTSLLEIDLSNNSLGEDFGKHLMKI 405

  Fly   585 LTANMKVTHFDCRD--CDLDEQEEFE 608
            ::.|..:...|.|:  ..||.:.:|:
  Fly   406 ISCNKLLERLDLRNTGLSLDMRRKFQ 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18171	NP_647651.1	LRR_RI	<387..541	CDD:238064	41/199 (21%)
		leucine-rich repeat	420..447	CDD:275380	8/33 (24%)
		leucine-rich repeat	448..475	CDD:275380	8/29 (28%)
		leucine-rich repeat	476..505	CDD:275380	6/29 (21%)
		leucine-rich repeat	506..526	CDD:275380	6/19 (32%)
CG14325	NP_650641.2	leucine-rich repeat	202..239	CDD:275380	6/36 (17%)
		LRR_RI	<206..440	CDD:238064	55/241 (23%)
		leucine-rich repeat	240..271	CDD:275380	7/30 (23%)
		leucine-rich repeat	272..301	CDD:275380	10/35 (29%)
		leucine-rich repeat	302..326	CDD:275380	5/23 (22%)
		leucine-rich repeat	329..353	CDD:275380	7/24 (29%)
		leucine-rich repeat	356..383	CDD:275380	8/29 (28%)
		leucine-rich repeat	384..407	CDD:275380	5/22 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910