DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13930 and dync1i2b

DIOPT Version :9

Sequence 1:	NP_647645.1	Gene:	CG13930 / 38210	FlyBaseID:	FBgn0035256	Length:	685	Species:	Drosophila melanogaster
Sequence 2:	XP_009300385.1	Gene:	dync1i2b / 561612	ZFINID:	ZDB-GENE-090121-1	Length:	645	Species:	Danio rerio

Alignment Length:	739	Identity:	144/739 - (19%)
Similarity:	267/739 - (36%)	Gaps:	192/739 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RKDYRTADFEQLSRMIRDHPLMKEPGAEQQQLHKLR---TPEYRTKCVMRASLDDIAL--GINLY 65
            ||..|.|       .||:....||...::::|...:   :|......:.|...:..||  .:.:.
Zfish    13 RKKQRLA-------QIREEKKRKEEERKKKELDGRKEGASPPQEDSDLERKRREAEALLQSMGIT 70

  Fly    66 KLQLDTPMSPTLEEP---NYLKEPASSARSAHSARPPATPFIKVLLRKTPIVVLFERRSMTALAD 127
            ...:..|:....|:.   :||..|..|.    ||:...||                  |.|...|
Zfish    71 DASMVQPLRVVTEDTCLFHYLVPPPMSP----SAKSVGTP------------------SETGSQD 113

  Fly   128 TEEGRQVMEDNRKYDELLSGTDKTRRTVDADTQTMTALMKSRLVNTERLTTAQMG--------SY 184
            :.:|               ||..  ||:..|:...|.|:.|         .:|:|        |.
Zfish   114 SGDG---------------GTGP--RTLHWDSDPSTLLLHS---------DSQLGRGPLKLGMSK 152

  Fly   185 VSNFEMYDTYTDLEKSTTSVQVQGAKKMEITTYHVGGVDQFVGINCLPGFRLALMLTMRILASNV 249
            |:..:    :...|..:.|.:.|...:    |:|....::...        ||:|       ..|
Zfish   153 VTQVD----FPPKEMVSYSKETQTPTQ----THHKEDEEEEED--------LAVM-------QPV 194

  Fly   250 FEPQQ----RRYRNMAPPDPLAE-------------------------------DVKFKY----- 274
            .|||:    ::..:.|.|..|.|                               ||.|.|
Zfish   195 MEPQEEKDSQKEEDEASPHELTEEEKQQILHSEEFVTFFDHSSRIMERALSEQVDVFFDYSGRDL 259

  Fly   275 -------RLGLLWRLSPPSSDPK--VHQAVSDMSFCPSNGDIMAVAYGVYSHGKVSKLPRSGWVY 330
                   :.|....|:...:|.:  .|:.|:.:.:.|...:::..:|  .|:.:....| .|...
Zfish   260 QDKEGESQAGAKLSLNRQFADERWSKHRVVTCLDWSPQYPELLVASY--CSNEEAPHEP-DGVAL 321

  Fly   331 VWNIK-NPVNPERRYHYQVPVVTVEFSPTQPQLLAIGLHNGGVEVRDISGQDLPPLAVSQRLSSP 394
            |||:| ....||..:|.|..|::..|:...|.|:..|.::|.:.:.|.......|:..:...:|.
Zfish   322 VWNMKYKKTTPEYVFHCQSAVMSAAFAQFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSASA 386

  Fly   395 YFEPVTAIKWIYFEGDVGCRNPHITPFLATSQAGAVTKYRLINSPNMLGLEQQRLQRAEGELEGI 459
            :..||      |....||.:|.|  ..::.|..|.:..:.|    :||...|..|:.
Zfish   387 HTHPV------YCVNVVGTQNAH--NLISISTDGKMCSWSL----DMLSTPQDSLEL-------- 431

  Fly   460 PIERQPPAASLLANRHPQCLEIVLDPVQSDIYYVLTDEGTLY-KCSTNYPLQHLELRQVHDGP-- 521
             :.:|..:.::.:...|      |..|.:  :.|.:::|::| .|.........|:.:.|.||
Zfish   432 -VFKQSKSVAVTSMSFP------LGDVNN--FVVGSEDGSVYTACRHGSKAGISEMFEGHHGPIT 487

  Fly   522 -------AACMEFSPWSPRMYLTCGSDWCIRIWLAGILLPIVTLQHHLSPVHCARWSRTHSTILV 579
                   |..::||    .:::|...||.:::|......|:.:.:.:...|:...||.||..:..
Zfish   488 GLDCHTAAGPVDFS----HLFVTSSFDWTVKLWSTKNNKPLYSFEDNSDYVYDVMWSPTHPALFA 548

  Fly   580 SLSR-STVDIWDLRNSTMKPVSSTVIDADIFYTTFKFTHCGRSLAVGNEAGNLLMLSF-EDMPFP 642
            .:.. ..:|:|:|.|.|..|.:|..::.:......::.|.||.:|||:..|.|.:... |.:..|
Zfish   549 CVDGVGHLDLWNLNNETEVPTASVTVEGNPALNRVRWAHSGREVAVGDSEGQLHIYDVGEQISVP 613

  Fly   643 PHFQYKQLKRAIFKALSMQPDLRK 666
            ...::.:..|.:.:....:.|:.:
Zfish   614 RQDEWTRFVRTLTEINENREDVEE 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13930	NP_647645.1	WD40	<279..648	CDD:225201	82/383 (21%)
		WD40 repeat	295..344	CDD:293791	12/49 (24%)
		WD40 repeat	350..397	CDD:293791	9/46 (20%)
		WD40 repeat	400..473	CDD:293791	13/72 (18%)
		WD40 repeat	478..513	CDD:293791	6/35 (17%)
		WD40	<518..>593	CDD:295369	19/84 (23%)
		WD40 repeat	524..560	CDD:293791	7/35 (20%)
dync1i2b	XP_009300385.1	Dynein_IC2	145..173	CDD:288403	5/31 (16%)
		Spore_coat_CotO	153..>256	CDD:290858	21/125 (17%)
		WD40	283..605	CDD:295369	78/357 (22%)
		WD40 repeat	289..338	CDD:293791	12/51 (24%)
		WD40 repeat	343..382	CDD:293791	7/38 (18%)
		WD40	362..>606	CDD:225201	58/276 (21%)
		WD40 repeat	391..434	CDD:293791	13/63 (21%)
		WD40 repeat	442..490	CDD:293791	11/55 (20%)
		WD40 repeat	497..528	CDD:293791	7/34 (21%)
		WD40 repeat	534..575	CDD:293791	12/40 (30%)
		WD40 repeat	580..606	CDD:293791	8/25 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54336
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920