DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13930 and dync1i1

DIOPT Version :9

Sequence 1:	NP_647645.1	Gene:	CG13930 / 38210	FlyBaseID:	FBgn0035256	Length:	685	Species:	Drosophila melanogaster
Sequence 2:	XP_009290517.1	Gene:	dync1i1 / 561525	ZFINID:	ZDB-GENE-061215-62	Length:	647	Species:	Danio rerio

Alignment Length:	713	Identity:	148/713 - (20%)
Similarity:	257/713 - (36%)	Gaps:	183/713 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RKDYRTADFEQLSRMIRDHPLMKEPGAEQQQLHKLRTPEY--------RTKCVMRASLDDIALGI 62
            ||..|.|       .||:....||...::::...|:.||.        |.:....|.|..|  ||
Zfish    13 RKKQRLA-------QIREEKKRKEEERKKKESEMLQRPENVTEDSDLDRKRRETEALLQSI--GI 68

  Fly    63 N-----LYKLQL------------DTPMSPTLEEPNYLKEPASSARSAHSARPPATPFIKVLLRK 110
            :     :..|||            .|||||                |:.|..||
Zfish    69 SPEPPLVQPLQLLTWDTCYFHYLVPTPMSP----------------SSQSVSPP----------- 106

  Fly   111 TPIVVLFERRSMTALADTEEGRQVMEDNRKYDELLSGTDKTRRTVDADT------QTMTA----- 164
                      |.|...::.:|..|    .:|..|...||.:...:.||:      |.:.|
Zfish   107 ----------SETGSQESIDGGTV----ERYRTLQWDTDPSALQLLADSVHGCRMQRLGASKIVQ 157

  Fly   165 --LMKSRLVNTERLTTAQMGSYVSNFEMYDTYTDLEKSTTSVQVQGAKKMEITTYHVGGV----- 222
              .|...||...:.|...:.|.....|..:..:..:....|.|::..|..|:...|...:
Zfish   158 IDFMPKELVTYSKETQTPVASNQPEEEDDEELSVPKSEPASQQLEEEKTQEVEEVHPRELTNEEK 222

  Fly   223 DQFV-GINCLPGFRLALMLTMRILASNVFEPQQRRYRNMAPPDPLAEDVKFKY-------RLGLL 279
            :|.| ..:.|..|..::.:..|:||.:                   :|:.|.|       :.|.|
Zfish   223 EQIVHSEDFLFFFDRSIRVVERVLAED-------------------KDIFFDYSGRDMEDKEGDL 268

  Fly   280 WRLSPPSSDP-------KVHQAVSDMSFCPSNGDIMAVAYGVYSHGKVSKLPR--SGWVYVWNIK 335
            ...|..|.:.       ..|:.|:.:.:.|...:::..:|......     |.  .|.|.|||:|
Zfish   269 QAGSNLSFNRHFYDEHWSKHRVVTSLDWSPQYPELLVASYNTNEDA-----PHEPDGVVLVWNMK 328

  Fly   336 -NPVNPERRYHYQVPVVTVEFSPTQPQLLAIGLHNGGVEVRDISGQDLPPLAVSQRLSSPYFEPV 399
             ....||..:|.|..|::|.|:...|.|:..|.::|.:.:.|.......|:..:...::.:..||
Zfish   329 FKKATPEYIFHCQSSVMSVGFAQFHPNLVIGGTYSGQIAMWDNRSHRRTPVQRTPLSATAHTHPV 393

  Fly   400 TAIKWIYFEGDVGCRNPHITPFLATSQAGAVTKYRLINSPNMLGLEQQRLQRAEGELEGIPIERQ 464
                  |....||.:|.:  ..:..|..|.:..:.|    :||...|:       .:|.|..:.:
Zfish   394 ------YCVNVVGTQNAN--NLITVSTDGKMCSWSL----DMLSQPQE-------SMELIYNKSK 439

  Fly   465 PPAASLLANRHPQCLEIVLDPVQSDI--YYVLTDEGTLYKCSTNYPLQHL-ELRQVHDGPA---A 523
            |.|.:.:|  .|          .||:  |.|.::|||:|..|.:.....: |:...|.||.   :
Zfish   440 PVAVTCMA--FP----------ASDVNNYVVGSEEGTVYTASRHGSKAGIGEIFDGHQGPVTGIS 492

  Fly   524 C------MEFSPWSPRMYLTCGSDWCIRIWLAGILLPIVTLQHHLSPVHCARWSRTHSTILVSL- 581
            |      ::||    .::.|...||.:::|......|:.:.:.:...|:...||..|..:..::
Zfish   493 CHNAVGPVDFS----HLFTTSSFDWTVKLWSTKHNKPLYSFEDNADYVYDVMWSPVHPALFATVD 553

  Fly   582 SRSTVDIWDLRNSTMKPVSSTVIDADIFYTTFKFTHCGRSLAVGNEAGNLLMLSFEDMPFPPH 644
            ....:|:|:|.|.|..|.:|..::........::...||.:|||:..|.:.:....:....||
Zfish   554 GNGRLDLWNLNNYTEVPSASVSVEGGCALNRVRWASGGREVAVGDSEGRVWIYDVGEQLAVPH 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13930	NP_647645.1	WD40	<279..648	CDD:225201	85/389 (22%)
		WD40 repeat	295..344	CDD:293791	12/51 (24%)
		WD40 repeat	350..397	CDD:293791	9/46 (20%)
		WD40 repeat	400..473	CDD:293791	14/72 (19%)
		WD40 repeat	478..513	CDD:293791	9/37 (24%)
		WD40	<518..>593	CDD:295369	18/84 (21%)
		WD40 repeat	524..560	CDD:293791	8/41 (20%)
dync1i1	XP_009290517.1	Dynein_IC2	147..175	CDD:288403	6/27 (22%)
		WD40	215..608	CDD:225201	94/451 (21%)
		WD40	284..607	CDD:295369	80/362 (22%)
		WD40 repeat	292..337	CDD:293791	11/49 (22%)
		WD40 repeat	347..388	CDD:293791	8/40 (20%)
		WD40 repeat	394..437	CDD:293791	12/55 (22%)
		WD40 repeat	443..490	CDD:293791	15/58 (26%)
		WD40 repeat	498..530	CDD:293791	7/35 (20%)
		WD40 repeat	536..574	CDD:293791	10/37 (27%)
		WD40 repeat	582..608	CDD:293791	6/25 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54336
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820