DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13930 and dnai1.2

DIOPT Version :9

Sequence 1:	NP_647645.1	Gene:	CG13930 / 38210	FlyBaseID:	FBgn0035256	Length:	685	Species:	Drosophila melanogaster
Sequence 2:	NP_001074027.1	Gene:	dnai1.2 / 555705	ZFINID:	ZDB-GENE-070112-1302	Length:	660	Species:	Danio rerio

Alignment Length:	662	Identity:	138/662 - (20%)
Similarity:	250/662 - (37%)	Gaps:	150/662 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 QLDTPMSPTLEEPNYLKEPASSARSAHSARPPATPF--------IKVLLRKTPIVVLFERRSMTA 124
            |||.    |.||   |||..:...:|::...|....        .|.::....:.:.||......
Zfish    63 QLDL----TEEE---LKEEITRVLTANNPNAPQNVVRYSFKEGCYKTIVFVDQMAIHFELEGNLV 120

  Fly   125 LADTEEGRQVMEDNRKY-----DELLS------GTDKTRRT-----VDADTQTMTALMKSRLVNT 173
            ..:::|||::|..:.:.     ||.|.      |..:.:.|     :|..:||:..|.:.....|
Zfish   121 HKESDEGRRLMAKHTEREDCGGDERLENVPIKPGKREQKVTNQFNFIDRASQTLNNLPREISCQT 185

  Fly   174 ERLTTAQMGSYVSNFEMYDTYTD----LEKSTTSVQVQ--------GAKKMEITTYHVGGVDQFV 226
            |....|...:..:.:|:||.|.:    .|||....:.|        ..|||.........:.|..
Zfish   186 EPPPRANFSATANQWEIYDFYVEELQRREKSKEKQESQFPNKEEDRSKKKMIQAEAQSDDISQLA 250

  Fly   227 GINCLPGFRLALMLTMRILASNVFEPQQRRYRNMAPPDPLAEDVKF-----------KYRLGLLW 280
                     ....:..|::..|:|             |.:|:|..:           |..|..||
Zfish   251 ---------KPAEIIERMVNQNIF-------------DEVAQDFMYFEDAADEFRGEKGTLLPLW 293

  Fly   281 RLSPPSSDPKVHQAVSDMSFCPSN--GDIMAVAYGVYSHGKVSKLPRSGWVYVWNIKNPVNPERR 343
            :.....:     :.:|..:.|.::  .|:.||..|.|...:..:    |.:..:.:|||..||..
Zfish   294 KFQYDKA-----KGLSVTALCWNHIYSDLFAVGLGSYEFTQQER----GMLLFYTLKNPSFPEFI 349

  Fly   344 YHYQVPVVTVEFSPTQPQLLAIGLHNGGVEVRDISGQDLPPLAVSQRLSSPYFEPVTAIKWIYFE 408
            ::....|:.|:.......|:|:||::|.|.|.|:..:...|:..|...|..:...|..:||...:
Zfish   350 FNTDSGVMCVDIHEQLSYLVAVGLYDGCVSVYDLRKKSDQPMYNSIASSGKHTGAVWQVKWQKDD 414

  Fly   409 GDVGCRNPHITPFLATSQAGAVTKYRLINSPNMLGLEQQRLQRAEGELEGIPIERQPPAASLLAN 473
            .|    :.|  .|.:.|..|.|..:.|:                :.|:....|.:.||     .:
Zfish   415 LD----SNH--NFFSVSTDGRVVSWTLV----------------KHEIVFTDIIKLPP-----VD 452

  Fly   474 RHPQCLEIVLDPV--------QSDIYYVL-TDEGTLYKCSTNYPLQHLELRQVHDGPAACMEFSP 529
            :.|..|:.|:...        |.|.:::: |:.|.::|.|..|..:.||:...|....:|:.::|
Zfish   453 KVPDDLKNVVATAGTSLDFHKQKDHHFLVGTEAGKIHKGSKYYSSKFLEMYDAHFMTVSCVRWNP 517

  Fly   530 WSPRMYLTCGSDWCIRIWLAGILLPIVTLQHHLSPVHCARWSRTHSTILVSLSR-STVDIWDLR- 592
            :.|.::::||.||.::||...|..|:.|.:...|....| ||...||:..:::. ..|.::||.
Zfish   518 FHPNVFISCGWDWMVKIWDHTINSPVFTFELKSSVTDVA-WSPHSSTVFAAVTADGKVHVFDLSI 581

  Fly   593 NSTMKPVSSTVIDADIFYTTFKFTHCGRSLAVGNEAGNLLMLSFEDMPFPPHFQYKQLKRAIFKA 657
            |.........|:.........:|......:.||::.|.::                        :
Zfish   582 NKYEALCQQKVVSKKTRLLHIEFNPVHPIIIVGDDRGRVI------------------------S 622

  Fly   658 LSMQPDLRKQVK 669
            |.:.|:|||:.|
Zfish   623 LKLSPNLRKKPK 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13930	NP_647645.1	WD40	<279..648	CDD:225201	82/381 (22%)
		WD40 repeat	295..344	CDD:293791	13/50 (26%)
		WD40 repeat	350..397	CDD:293791	13/46 (28%)
		WD40 repeat	400..473	CDD:293791	13/72 (18%)
		WD40 repeat	478..513	CDD:293791	9/43 (21%)
		WD40	<518..>593	CDD:295369	22/76 (29%)
		WD40 repeat	524..560	CDD:293791	12/35 (34%)
dnai1.2	NP_001074027.1	WD40	<296..650	CDD:225201	86/400 (22%)
		WD40	354..620	CDD:295369	67/293 (23%)
		WD40 repeat	357..397	CDD:293791	11/39 (28%)
		WD40 repeat	405..485	CDD:293791	20/106 (19%)
		WD40 repeat	511..547	CDD:293791	12/35 (34%)
		WD40 repeat	552..591	CDD:293791	9/39 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D310818at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820