DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13930 and dnai4

DIOPT Version :9

Sequence 1:	NP_647645.1	Gene:	CG13930 / 38210	FlyBaseID:	FBgn0035256	Length:	685	Species:	Drosophila melanogaster
Sequence 2:	NP_001018595.1	Gene:	dnai4 / 553797	ZFINID:	ZDB-GENE-050522-322	Length:	778	Species:	Danio rerio

Alignment Length:	734	Identity:	161/734 - (21%)
Similarity:	294/734 - (40%)	Gaps:	128/734 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 IRDHPLMK-EPGAEQQQLHKLRTPEYRTKCVMRASLDDIALGINLYKLQ---------------- 68
            :..|||.. :||..|.:..|:.| ...|..........||.......|.
Zfish    79 VTPHPLYNPDPGVLQSKQGKVFT-ALDTSLTTMTEFPSIAFQTTNASLTGPFTRSFFGSASASRI 142

  Fly    69 LDTPMSPTLEEPNYL-KEPASSARS---AHSARPPATPFIKVL-------LRKTPIVVLFERRSM 122
            ..|..|.|.|..:.| |:..|::.|   :|...|.......:|       |.:|..:.|.:..::
Zfish   143 SQTAESVTDETKDLLVKQDLSNSISDIQSHREEPKEQLRENILDSTANCYLSETETIWLLDIPAV 207

  Fly   123 TALADTEEGRQVMEDNRKYDELLSGTDKTRRTVDADTQTMTALMKSRLVNTERLTTAQMGSYVSN 187
            :...::|:...|.|.|..|.||........:.|:...||.:...|::.|..:.:|........:.
Zfish   208 SVSLESEDAEAVKERNNAYTELCKNRQGNDKYVERSMQTFSDAPKTKEVQCDSITMVDKAVMCTV 272

  Fly   188 FEMYDTYTDLEKSTTSVQVQGAKKMEIT--------------------------------TYHVG 220
            ::|||::.::...:.:. |..:::.|.|                                :.|:.
Zfish   273 WDMYDSFNNISDVSANT-VVSSERHEATIPESSPEGHLVHPKRSNQSLSVVSTVSTVSGSSTHIE 336

  Fly   221 GVDQFVGINCLPGFRLALM---------LTMRILASNVFEPQQRRYRNMAPPDPLAED---VKFK 273
            .:...:.::..|..:|.|.         |..|::.:|||:|:...||.:    |:.||   |:..
Zfish   337 KMACVLPLDEEPDLQLILQSDKLKQDLALMERVVLANVFQPKLAAYRQL----PIIEDPDCVQMV 397

  Fly   274 YR---------------LGLLWRLSPPSSDPKVHQAVSDMSFCPSNGDIMAVAYGVYSHGKVSKL 323
            ..               |..||..   |.:..:.:.|:.|.:...|.|::||.||....    |.
Zfish   398 MEEESWTEQSKNSHCPFLERLWDF---SCELTMGRNVTCMVWNKKNPDLLAVGYGQVEF----KN 455

  Fly   324 PRSGWVYVWNIKNPVNPERRYHYQVPVVTVEFSPTQPQLLAIGLHNGGVEVRDISGQDLPPLAVS 388
            |.||.|..|::|||..|:|.::.:..|..::||.:....||:|:::|.:.:.::...:..|:..|
Zfish   456 PNSGLVCCWSLKNPTWPDRVFYCESGVTALDFSASNANQLAVGMYDGTIAIYNVQTSEQTPITDS 520

  Fly   389 QRLSSPYFEPVTAIKWIYFEGDVGCRNPHITPFLATSQAGAVTK---YRLINSPNMLGLEQQRLQ 450
            ...::.:..||..:.||..|..:......|  .::.|..|.::|   |:.:...:::.|:...||
Zfish   521 SDCANLHTSPVWQLTWIDHEDGLAADKGEI--LVSVSSDGRISKWIHYKSMECVDLMKLKIHDLQ 583

  Fly   451 RAEGELEGIPIERQPPAASLLANRHPQCLEIVLDPVQSDIYYVLTDEGTLYKCSTNYPLQHLELR 515
            ..:      .|....|.         .|.:  ..|..|.||.|.|:||.::|||::|..|:|:..
Zfish   584 WKQ------HISSLTPG---------MCFD--FHPNDSKIYLVGTEEGHIHKCSSSYNEQYLDSY 631

  Fly   516 QVHDGPAACMEFSPWSPRMYLTCGSDWCIRIWLAGILLPIVTLQHHLSPVHCARWSRTHSTILVS 580
            :.|..|...:.:||:...::|:|.|||.|::|...:.:|::........|....||...:|:..:
Zfish   632 KAHKRPVYKVTWSPFCSDVFLSCSSDWTIQLWRQDLQIPVMGFTSGQRVVFDIMWSPHCATVFGA 696

  Fly   581 LSRSTVDIWDLRNSTMKPVSSTVIDADIFYTTFKF---THCGRSLAVGNEAGNLLMLSFEDMPFP 642
            :|...|:|||||.|::.|.........:..|...|   |.|   :.||:..|.:.:...:::...
Zfish   697 VSEGKVEIWDLRVSSLDPTLVNWTSPGVNPTALLFSPETDC---VLVGDSEGQVTVYKLKNITAG 758

  Fly   643 PHFQYKQLKRAIFKALSMQ 661
            ...|.:.|:..|...||.|
Zfish   759 GGSQGETLEDVIQSTLSSQ 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13930	NP_647645.1	WD40	<279..648	CDD:225201	94/374 (25%)
		WD40 repeat	295..344	CDD:293791	19/48 (40%)
		WD40 repeat	350..397	CDD:293791	9/46 (20%)
		WD40 repeat	400..473	CDD:293791	13/75 (17%)
		WD40 repeat	478..513	CDD:293791	14/34 (41%)
		WD40	<518..>593	CDD:295369	22/74 (30%)
		WD40 repeat	524..560	CDD:293791	10/35 (29%)
dnai4	NP_001018595.1	WD40 repeat	431..473	CDD:293791	17/45 (38%)
		WD40	<459..754	CDD:225201	79/316 (25%)
		WD 1. /evidence=ECO:0000255	477..517		7/39 (18%)
		WD40	479..751	CDD:295369	71/293 (24%)
		WD40 repeat	483..526	CDD:293791	8/42 (19%)
		WD 2. /evidence=ECO:0000255	526..573		10/48 (21%)
		WD40 repeat	531..576	CDD:293791	9/46 (20%)
		WD 3. /evidence=ECO:0000255	586..629		16/59 (27%)
		WD40 repeat	589..624	CDD:293791	13/45 (29%)
		WD 4. /evidence=ECO:0000255	633..673		12/39 (31%)
		WD40 repeat	638..675	CDD:293791	10/36 (28%)
		WD 5. /evidence=ECO:0000255	676..715		12/38 (32%)
		WD40 repeat	681..707	CDD:293791	8/25 (32%)
		WD 6. /evidence=ECO:0000255	721..760		7/41 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	111	1.000	Domainoid score	I6196
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H11702
Inparanoid	1	1.050	170	1.000	Inparanoid score	I4110
OMA	1	1.010	-	-		QHG54336
OrthoDB	1	1.010	-	-		D310818at33208
OrthoFinder	1	1.000	-	-		FOG0006125
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104291
Panther	1	1.100	-	-	LDO	PTHR12442
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5769
SonicParanoid	1	1.000	-	-		X6183
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.870