DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13930 and CG1571

DIOPT Version :9

Sequence 1:	NP_647645.1	Gene:	CG13930 / 38210	FlyBaseID:	FBgn0035256	Length:	685	Species:	Drosophila melanogaster
Sequence 2:	NP_572435.1	Gene:	CG1571 / 31725	FlyBaseID:	FBgn0029993	Length:	651	Species:	Drosophila melanogaster

Alignment Length:	597	Identity:	135/597 - (22%)
Similarity:	224/597 - (37%)	Gaps:	153/597 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 ERRSMTALADTEEGRQVMEDNRKYDELL-----SGTDKTRRTVDADTQTMTAL---MKSRLVNTE 174
            |||..        |||....:|  :||:     ||..:.:..:...::..|.|   |...::.||
  Fly    11 ERRRF--------GRQCRFQDR--NELMVSVHPSGRQRLKYIMANPSEKSTQLSRQMALTVMETE 65

  Fly   175 RLTTAQMGSYVSNFEMYD-------TYTDLEKSTTSVQVQGAKKMEITTYHVGGVDQFVGINCLP 232
            .:|..|.|.|     .|:       .:.|.|::.     :..||:|        .:...|...|.
  Fly    66 NVTLDQHGMY-----HYEGGWPKEVNFNDEEQTQ-----RHRKKVE--------REDSWGEQVLS 112

  Fly   233 GFRLALMLTMRILASNVFEPQQRRYRNM---APPDPLAEDVKFKYRLGL------LWRLSPPSSD 288
            ..|..:.:..:....|:       |:|.   .||: |..|:|.::|..:      ||.   |:
  Fly   113 MIRTTMSVAEQNNTLNI-------YQNFFADLPPE-LGHDIKMRFRARVANVFHDLWL---PA-- 164

  Fly   289 PKVHQAVSDMSFCPSNGDIMAVAY-GVYSHGK----VSKLPRSG--WVYVWNIKNPVNPERRYHY 346
                :.:..:.:.|:|.......| ..::.|:    |:..|..|  ..|||::|||:.|...|..
  Fly   165 ----RQLRSIEWMPNNSRQFMTQYTNHFAKGERLRPVTDEPFGGTNGFYVWDVKNPLKPRITYDS 225

  Fly   347 QVPVVTVEFSPTQP----------QLLAIGLHNGGVEVRDISGQDLPPLAVSQRLSSPYFEPVTA 401
            :..|...:..|...          |:...|...||:.:|:.      ||.||.|      |..:|
  Fly   226 KQQVSLAKICPKDENNMVGGTGLGQVCLWGTFKGGLPIRNC------PLEVSHR------ETTSA 278

  Fly   402 IKWIYFEGDVGCRNPHITPFLATSQAGAVTKY---RLINSPNMLGLEQQRLQRAEGELEGIPIER 463
            :.|::.:.:        |.|.:.|..|:: ||   |.:..|      .|.|.     ||..|.||
  Fly   279 LCWVHSKSN--------TEFYSGSLDGSI-KYWDTRDLKMP------MQELL-----LEPEPQER 323

  Fly   464 QPPAASLLANRHPQCLEIVLD-PVQ----SDIYYV-------LTDEGTLYKCSTNYPLQHLELRQ 516
            |    |.:.:.....||.... ||:    ||:.:|       :|...||        |.|.   |
  Fly   324 Q----SRMDSHGVTVLEFEYTIPVRFIIGSDMGHVFVGNRKGMTPMETL--------LAHY---Q 373

  Fly   517 VHDGPAACMEFSPWSPRMYLTCGSDWCIRIWLAGIL-LPIVTLQHHLSPVHCARWSRTHSTILVS 580
            :..||...:..:|:..:.:|..| ||..|||...:. .|........:.:.|..||....::.|:
  Fly   374 LFVGPVRSINRNPFFVKNFLVTG-DWRARIWSEEVKDSPSTMYFRKNAQILCGAWSTGRCSLFVT 437

  Fly   581 LS-RSTVDIWDLRNSTMKPVSSTVIDADIFYTTFKFTHCGRSLAVGNEAGNLLMLSFEDMPFPPH 644
            .. ...||.|||.....||:.|  :|..:......|...|..||:|.:.|:..:::.::......
  Fly   438 GDINGVVDFWDLLLHHRKPIRS--VDFKVAIADLVFRPEGDLLAIGLKNGDTHIMTLDESMRQAT 500

  Fly   645 FQYKQLKRAIFK 656
            .:.|.|..|:|:
  Fly   501 GKEKALMAAMFE 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13930	NP_647645.1	WD40	<279..648	CDD:225201	93/402 (23%)
		WD40 repeat	295..344	CDD:293791	14/55 (25%)
		WD40 repeat	350..397	CDD:293791	12/56 (21%)
		WD40 repeat	400..473	CDD:293791	19/75 (25%)
		WD40 repeat	478..513	CDD:293791	12/46 (26%)
		WD40	<518..>593	CDD:295369	20/76 (26%)
		WD40 repeat	524..560	CDD:293791	9/36 (25%)
CG1571	NP_572435.1	WD40	210..462	CDD:295369	75/301 (25%)
		WD40	211..>488	CDD:225201	81/326 (25%)
		WD40 repeat	229..269	CDD:293791	8/45 (18%)
		WD40 repeat	277..325	CDD:293791	18/71 (25%)
		WD40 repeat	332..369	CDD:293791	10/44 (23%)
		WD40 repeat	379..415	CDD:293791	9/36 (25%)
		WD40 repeat	422..447	CDD:293791	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45435271
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12442
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840