DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13930 and Dnai4

DIOPT Version :9

Sequence 1:	NP_647645.1	Gene:	CG13930 / 38210	FlyBaseID:	FBgn0035256	Length:	685	Species:	Drosophila melanogaster
Sequence 2:	XP_036020022.1	Gene:	Dnai4 / 242584	MGIID:	2385328	Length:	812	Species:	Mus musculus

Alignment Length:	724	Identity:	181/724 - (25%)
Similarity:	310/724 - (42%)	Gaps:	137/724 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 HPLMKEPGAEQQQLHKLRTPE--------------YR-----------TKCVMRASLDDIALGIN 63
            ||   :|.|...:.:||.|.:              |:           |:.|:.:|      .::
Mouse    91 HP---DPHAASAKPNKLLTSQEGSLGSDYISSYSLYQNTLNPSMLGQYTRSVLGSS------SVS 146

  Fly    64 LYKLQLDTPMSPTLEEPNYLKEPASSARSAHSARPPA---------TPFIKVLLRKTPIVVLFER 119
            ...:.....||..||:.:|.::..:|.......|..|         ...|:::|.:|..:..|:.
Mouse   147 KSSISTTESMSEDLEDSSYKRDRLASFTDVRVLRSTAEAAISKEELEKTIEIILTETETLRFFDL 211

  Fly   120 RSMTALADTEEGRQVMEDNRKYDELLSGTDKTRRTVDADTQTMTALMKSRLVNTERLTTAQMGSY 184
            .::....::||..:::|.|:||:.|..........|:...||.....|::.|..|::...:.|..
Mouse   212 PTVMFSTESEEAEKIIEKNKKYETLCRNRLGNDLYVERMMQTFNGAPKNKEVQCEKIILEEKGVV 276

  Fly   185 VSNFEMYDTYT-----------------DLEKSTTSVQVQGAKK---MEITTYHVGGVDQFVGIN 229
            .:.:::||:|.                 .|.......::|.::.   |:|....:..|.:....|
Mouse   277 ATTWDLYDSYNIPETLLAAKRSGYSSKGSLPAKDRDPKIQDSESSSLMDIENVILAKVQEDEEDN 341

  Fly   230 ---CLPGFRL--ALMLTMRILASNVFEPQQRRYRNM------APPDP----------LAED---- 269
               .|...:|  .|....|:|..|||:|:...||.:      .|.:|          :|||
Mouse   342 SEAILKSDKLHQDLFYMERVLMENVFQPKLAAYRQLPVYKEHEPEEPEETLQVENLKVAEDEPKK 406

  Fly   270 -----VKFKYRLGL----------LWRLSPPSSDPKVHQAVSDMSFCPSNGDIMAVAYGVYSHGK 319
                 |:.:..|.:          |.||...|.|......||.:|:..:|.|::||.||.:...:
Mouse   407 EDEEEVEMELELEIATEQSTIPANLERLWSFSCDLTKGLNVSSLSWNKANPDLLAVGYGNFGFRE 471

  Fly   320 VSKLPRSGWVYVWNIKNPVNPERRYHYQVPVVTVEFSPTQPQLLAIGLHNGGVEVRDI-SGQDLP 383
            ..|    |....|:||||:.|||.|.....|.:|:||.:.|.|||:|.|||.|.:.:: |..::|
Mouse   472 QKK----GMACCWSIKNPMWPERIYQSSYGVTSVDFSNSSPNLLAVGYHNGTVAIYNVQSSHNIP 532

  Fly   384 PLAVSQRLSSP--YFEPVTAIKWIYFEGDVGCRNPHITPFLATSQA-GAVTKYRLINSPNMLGLE 445
            .|..|:   ||  :..||..::||  |.|.|.........|.:..| |.::|: :|..    ||:
Mouse   533 VLDSSE---SPQKHLGPVWQVQWI--EQDRGTTGDDKREILVSISADGRISKW-IIRK----GLD 587

  Fly   446 QQRLQR-----AEGELEGIPIERQPPAASLLANRHP-QCLEIVLDPVQSDIYYVLTDEGTLYKCS 504
            ...|.|     |.|..:|  .|::....:|::.:.| .|  ....|..::||...|:||.::|||
Mouse   588 CHDLMRLKRTTATGGKKG--GEKEKKGEALISRQAPGMC--FAFHPKDTNIYLAGTEEGLIHKCS 648

  Fly   505 TNYPLQHLELRQVHDGPAACMEFSPWSPRMYLTCGSDWCIRIWLAGILLPIVTLQHHLSPVHCAR 569
            .:|..|:||..:.|.||...:.::|:.|.::|:|.:||.:.||....:.|.::.......|:...
Mouse   649 CSYNEQYLETYRGHKGPVYKVTWNPFCPDVFLSCSADWGVMIWHQDTVKPFLSFYPTTYVVYDVS 713

  Fly   570 WSRTHSTILVSLSRSTVDIWDLRNSTMKPVSSTVIDADIFYTTFKF---THCGRSLAVGNEAGNL 631
            ||...:.|..:.:.:.|:||||:.||:.|:...|.:..|.:||..|   |.|   |.||:..|.:
Mouse   714 WSPKSAYIFAAANENRVEIWDLQISTLDPLIVNVANPGIKFTTVLFAKETDC---LLVGDSDGQV 775

  Fly   632 LMLSFEDMP 640
            .:....:||
Mouse   776 AVYELRNMP 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13930	NP_647645.1	WD40	<279..648	CDD:225201	117/375 (31%)
		WD40 repeat	295..344	CDD:293791	19/48 (40%)
		WD40 repeat	350..397	CDD:293791	19/49 (39%)
		WD40 repeat	400..473	CDD:293791	19/78 (24%)
		WD40 repeat	478..513	CDD:293791	12/34 (35%)
		WD40	<518..>593	CDD:295369	21/74 (28%)
		WD40 repeat	524..560	CDD:293791	9/35 (26%)
Dnai4	XP_036020022.1	WD40	<444..792	CDD:225201	112/362 (31%)
		WD40 repeat	448..493	CDD:293791	18/48 (38%)
		WD40 repeat	498..542	CDD:293791	19/46 (41%)
		WD40 repeat	548..617	CDD:293791	19/77 (25%)
		WD40 repeat	622..660	CDD:293791	14/39 (36%)
		WD40 repeat	667..702	CDD:293791	9/34 (26%)
		WD40 repeat	709..741	CDD:293791	11/31 (35%)
		WD40 repeat	751..780	CDD:293791	10/31 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	119	1.000	Domainoid score	I5791
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H11702
Inparanoid	1	1.050	185	1.000	Inparanoid score	I3927
Isobase	1	0.950	-	0	Normalized mean entropy	S8095
OMA	1	1.010	-	-		QHG54336
OrthoDB	1	1.010	-	-		D310818at33208
OrthoFinder	1	1.000	-	-		FOG0006125
OrthoInspector	1	1.000	-	-		otm42488
orthoMCL	1	0.900	-	-		OOG6_104291
Panther	1	1.100	-	-	LDO	PTHR12442
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5769
SonicParanoid	1	1.000	-	-		X6183
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.920