DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13930 and DYNC1I1

DIOPT Version :9

Sequence 1:	NP_647645.1	Gene:	CG13930 / 38210	FlyBaseID:	FBgn0035256	Length:	685	Species:	Drosophila melanogaster
Sequence 2:	NP_004402.1	Gene:	DYNC1I1 / 1780	HGNCID:	2963	Length:	645	Species:	Homo sapiens

Alignment Length:	742	Identity:	136/742 - (18%)
Similarity:	263/742 - (35%)	Gaps:	196/742 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RKDYRTADF--------EQLSRMIRDHPLMKEPGAEQQQLHKLRTPEYRTKCVMRASLDDIALGI 62
            ||..|.|..        |:..:...|....|||..:...|.:.|.   .|:.:::      ::||
Human    13 RKKQRLAQIREEKKRKEEERKKKEADMQQKKEPVQDDSDLDRKRR---ETEALLQ------SIGI 68

  Fly    63 N--------LYKLQLD---------TPMSP------------------------TLE---EPNYL 83
            :        |:.|..|         |||||                        ||:   :|:.|
Human    69 SPEPPLVQPLHFLTWDTCYFHYLVPTPMSPSSKSVSTPSEAGSQDSGDLGPLTRTLQWDTDPSVL 133

  Fly    84 KEPASS--ARSAHSARPPATPFIKVLLRKTPIVVLFERRSMTALA-----DTEEGRQVMEDNRKY 141
            :..:.|  .|..|.........:..|.|:   ||.:.:.:.|.||     :.||..:::|.....
Human   134 QLQSDSELGRRLHKLGVSKVTQVDFLPRE---VVSYSKETQTPLATHQSEEDEEDEEMVESKVGQ 195

  Fly   142 DELLSGTDKTRRTVDADTQTMTALMKSRLVNTE-------RLTTAQMGSYVSNFEMYDTYTDLEK 199
            |..|...||.:...:|..:.:|...|.:::::|       |.......:...:.:::..|:..|.
Human   196 DSELENQDKKQEVKEAPPRELTEEEKQQILHSEEFLIFFDRTIRVIERALAEDSDIFFDYSGREL 260

  Fly   200 STTSVQVQGAKKMEITTYHVGGVDQFVGINCLPGFRLALMLTMRILASNVFEPQQRRYRNMAPPD 264
            ......||....:....       ||                        ::....::|.:...|
Human   261 EEKDGDVQAGANLSFNR-------QF------------------------YDEHWSKHRVVTCMD 294

  Fly   265 PLAEDVKFKYRLGLLWRLSPPSSDPKVHQAVSDMSFCPSNGDIMAVAYGVYSHGKVSKLPRSGWV 329
                           |.|..|                    ::|..:   |::.:.:.....|..
Human   295 ---------------WSLQYP--------------------ELMVAS---YNNNEDAPHEPDGVA 321

  Fly   330 YVWNIK-NPVNPERRYHYQVPVVTVEFSPTQPQLLAIGLHNGGVEVRDISGQDLPPLAVSQRLSS 393
            .|||:| ....||..:|.|..|::|.|:...|.|:..|.::|.:.:.|.......|:..:...::
Human   322 LVWNMKFKKTTPEYVFHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHRRTPVQRTPLSAA 386

  Fly   394 PYFEPVTAIKWIYFEGDVGCRNPHITPFLATSQAGAVTKYRLINSPNMLGLEQQRLQRAEGELEG 458
            .:..||      |....||.:|.|  ..:..|..|.:..:.|    :||...|:       .:|.
Human   387 AHTHPV------YCVNVVGTQNAH--NLITVSTDGKMCSWSL----DMLSTPQE-------SMEL 432

  Fly   459 IPIERQPPAASLLANRHPQCLEIVLDPVQSDI--YYVLTDEGTLY-KCSTNYPLQHLELRQVHDG 520
            :..:.:|.|.:.:|  .|          ..|:  :.|.::|||:| .|.........|:.:.|.|
Human   433 VYNKSKPVAVTGMA--FP----------TGDVNNFVVGSEEGTVYTACRHGSKAGIGEVFEGHQG 485

  Fly   521 PAA---C------MEFSPWSPRMYLTCGSDWCIRIWLAGILLPIVTLQHHLSPVHCARWSRTHST 576
            |..   |      ::||    .:::|...||.:::|......|:.:.:.:...|:...||..|..
Human   486 PVTGINCHMAVGPIDFS----HLFVTSSFDWTVKLWTTKHNKPLYSFEDNADYVYDVMWSPVHPA 546

  Fly   577 ILVSL-SRSTVDIWDLRNSTMKPVSSTVIDADIFYTTFKFTHCGRSLAVGNEAGNLLMLSFEDMP 640
            :...: ....:|:|:|.|.|..|.:|..|:........::...|:.:|||:..|.:.:....::.
Human   547 LFACVDGMGRLDLWNLNNDTEVPTASVAIEGASALNRVRWAQAGKEVAVGDSEGRIWVYDVGELA 611

  Fly   641 FPPHFQYKQLKRAIFKALSMQPDLRKQ 667
            .|.:.::.:..|.:.:..:.:.|..::
Human   612 VPHNDEWTRFARTLVEIRANRADSEEE 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13930	NP_647645.1	WD40	<279..648	CDD:225201	78/382 (20%)
		WD40 repeat	295..344	CDD:293791	9/49 (18%)
		WD40 repeat	350..397	CDD:293791	9/46 (20%)
		WD40 repeat	400..473	CDD:293791	14/72 (19%)
		WD40 repeat	478..513	CDD:293791	7/37 (19%)
		WD40	<518..>593	CDD:295369	18/84 (21%)
		WD40 repeat	524..560	CDD:293791	8/41 (20%)
DYNC1I1	NP_004402.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58		11/47 (23%)
		Interaction with DCTN1. /evidence=ECO:0000250	2..123		22/118 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..125		5/29 (17%)
		Dynein_IC2	147..173	CDD:371592	4/28 (14%)
		Interaction with DYNLT1. /evidence=ECO:0000269\|PubMed:27502274	147..163		2/18 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..221		12/51 (24%)
		WD40	283..606	CDD:392136	79/395 (20%)
		WD 1	285..334		12/86 (14%)
		WD40 repeat	291..337	CDD:293791	13/83 (16%)
		WD 2	338..378		10/39 (26%)
		WD40 repeat	346..385	CDD:293791	8/38 (21%)
		WD 3	387..428		12/52 (23%)
		WD40 repeat	393..434	CDD:293791	12/53 (23%)
		WD 4	437..477		11/51 (22%)
		WD40 repeat	442..481	CDD:293791	10/50 (20%)
		WD 5	482..527		11/48 (23%)
		WD40 repeat	488..529	CDD:293791	8/44 (18%)
		WD 6	530..570		9/39 (23%)
		WD40 repeat	535..573	CDD:293791	10/37 (27%)
		WD 7	576..615		6/38 (16%)
		WD40 repeat	581..607	CDD:293791	5/25 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54336
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820