DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13930 and dyci-1

DIOPT Version :9

Sequence 1:	NP_647645.1	Gene:	CG13930 / 38210	FlyBaseID:	FBgn0035256	Length:	685	Species:	Drosophila melanogaster
Sequence 2:	NP_001370459.1	Gene:	dyci-1 / 177440	WormBaseID:	WBGene00015927	Length:	643	Species:	Caenorhabditis elegans

Alignment Length:	385	Identity:	82/385 - (21%)
Similarity:	148/385 - (38%)	Gaps:	79/385 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   286 SSDPKVHQA-------------VSDMSFCPSNGDIMAVAYGVYSHGKVSKLPRS--GWVYVWNIK 335
            :||..:|.|             |:.|:|.....|::||:||      ...:|..  |.:.|||.|
Worm   264 ASDDLLHLAQVYQDETWTAKRLVTGMAFSEHYPDLLAVSYG------PCDIPNEPPGVIVVWNTK 322

  Fly   336 NP-VNPERRYHYQVPVVTVEFSPTQPQLLAIGLHNGGVEVRD--ISGQDLP----PLAVSQRLSS 393
            :. :..|...:.|..:.:|.|:.....||..|..:|.:.|.|  ::.:.||    ||...   :.
Worm   323 SKRMTAEFIVYCQSEIQSVAFARFHAHLLLAGCESGQICVWDNRLTSRKLPINRSPLTTQ---AH 384

  Fly   394 PYFEPVTAIKWIYFEGDVGCRNPHITPFLATSQAGAVTKYRLIN--SPNMLGLEQQRLQRAEGEL 456
            .|.....|:        ||.:|.|  .|::.|:.|.:..:.:.|  .|    ::.:.|...||:
Worm   385 TYTVSCLAV--------VGTKNAH--NFVSLSRDGRICSWNVDNLTQP----VDGKELMTKEGK- 434

  Fly   457 EGIPIERQPPAASLLANRHPQCLEIVLDPVQSDIYYVLTDEGTLYKCSTNYPLQHLELRQV---- 517
                      |||......|      :..:|:  :.|.||.|.:...|.|.....:....|
Worm   435 ----------AASATRMSFP------IGEMQT--FVVGTDTGEILAASRNGADPAVIKTDVCYKG 481

  Fly   518 HDGPAACMEFSPWS-----PRMYLTCGSDWCIRIWLAGILLPIVTLQHHLSPVHCARWSRTHSTI 577
            |.|....:||...|     ..::::...||.:::|.........:.:.|...|....||..|..:
Worm   482 HSGTLTGIEFHRASGVVDFSHLFISSSHDWTVKLWSTKDANLKFSFESHPDLVLDVAWSPVHPAV 546

  Fly   578 LVSL-SRSTVDIWDLRNSTMKPVSSTVIDAD---IFYTTFKFTHCGRSLAVGNEAGNLLM 633
            ..|: :...:.:|:|......||:.....|:   ::.....::..|:.:.||::.|.:.|
Worm   547 FASIDADGNIFVWNLNEDVEGPVARLRAGAEGESVYMNRLIWSPDGKHVFVGDDEGRVHM 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13930	NP_647645.1	WD40	<279..648	CDD:225201	82/385 (21%)
		WD40 repeat	295..344	CDD:293791	15/51 (29%)
		WD40 repeat	350..397	CDD:293791	13/52 (25%)
		WD40 repeat	400..473	CDD:293791	16/74 (22%)
		WD40 repeat	478..513	CDD:293791	7/34 (21%)
		WD40	<518..>593	CDD:295369	16/80 (20%)
		WD40 repeat	524..560	CDD:293791	6/40 (15%)
dyci-1	NP_001370459.1	WD40 repeat	286..333	CDD:293791	15/52 (29%)
		WD40 repeat	339..383	CDD:293791	12/46 (26%)
		WD40	382..>611	CDD:421866	50/261 (19%)
		WD40 repeat	388..457	CDD:293791	20/101 (20%)
		WD40 repeat	487..528	CDD:293791	6/40 (15%)
		WD40 repeat	534..573	CDD:293791	9/38 (24%)
		WD40 repeat	581..609	CDD:293791	5/26 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54336
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820