DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13930 and Dync1i2

DIOPT Version :9

Sequence 1:	NP_647645.1	Gene:	CG13930 / 38210	FlyBaseID:	FBgn0035256	Length:	685	Species:	Drosophila melanogaster
Sequence 2:	NP_446332.2	Gene:	Dync1i2 / 116659	RGDID:	620174	Length:	638	Species:	Rattus norvegicus

Alignment Length:	652	Identity:	123/652 - (18%)
Similarity:	233/652 - (35%)	Gaps:	189/652 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 DIALGINLYKL------QLDTP-----------MSPTLEEPNYLKEPASSARSAHSARPPATPFI 104
            |..||....||      |:|.|           .:|...:|   ||.........:.:||..|..
  Rat   128 DSDLGRGPIKLGMAKITQVDFPPREIVTYTKETQTPVTAQP---KEDEEEEDDVAAPKPPVEPEE 189

  Fly   105 KVLLR-------KTPIVVLFERRSMTALADTEEGRQVMEDNRKYDELLSGTDKTRRTVDADTQTM 162
            :.:|:       |.|...|.|          ||.:|::..    :|.||..|.:.|.|
  Rat   190 EKILKKDEENDSKAPPHELTE----------EEKQQILHS----EEFLSFFDHSTRIV------- 233

  Fly   163 TALMKSRLVNTERLTTAQMGSYVSNFEMYDTYT--DLEKSTTSVQVQGAKKMEITTYHVGGVDQF 225
                       ||..:.|:..:      :| |:  |||.....:|.
  Rat   234 -----------ERALSEQINIF------FD-YSGRDLEDKEGEIQA------------------- 261

  Fly   226 VGINCLPGFRLALMLTMRILASNVFEPQQRRYRNMAPPDPLAEDVKFKYRLGLLWRLSPPSSDPK 290
                   |.:|:|               .|::              |..|    |         .
  Rat   262 -------GAKLSL---------------NRQF--------------FDER----W---------S 277

  Fly   291 VHQAVSDMSFCPSNGDIMAVAYGVYSHGKVSKLPRSGWVYVWNIK-NPVNPERRYHYQVPVVTVE 354
            .|:.||.:.:.....:::..:   |::.:.:.....|...|||:| ....||..:|.|..|::..
  Rat   278 KHRVVSCLDWSSQYPELLVAS---YNNNEEAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSAT 339

  Fly   355 FSPTQPQLLAIGLHNGGVEVRDISGQDLPPLAVSQRLSSPYFEPVTAIKWIYFEGDVGCRNPHIT 419
            |:...|.|:..|.::|.:.:.|.......|:..:...::.:..||      |....||.:|.|
  Rat   340 FAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPV------YCVNVVGTQNAH-- 396

  Fly   420 PFLATSQAGAVTKYRLINSPNMLGLEQQRLQRAEGELEGIPIERQPPAASLLANRHPQCLEIVLD 484
            ..::.|..|.:..:.|    :||...|..::.         :.:|..|.::.:...|
  Rat   397 NLISISTDGKICSWSL----DMLSHPQDSMEL---------VHKQSKAVAVTSMSFP-------- 440

  Fly   485 PVQSDI--YYVLTDEGTLY-KCSTNYPLQHLELRQVHDGP---------AACMEFSPWSPRMYLT 537
              ..|:  :.|.::||::| .|.........|:.:.|.||         ...::||    .:::|
  Rat   441 --VGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFS----HLFVT 499

  Fly   538 CGSDWCIRIWLAGILLPIVTLQHHLSPVHCARWSRTHSTILVSL-SRSTVDIWDLRNSTMKPVSS 601
            ...||.:::|......|:.:.:.:...|:...||.||..:...: ....:|:|:|.|.|..|.:|
  Rat   500 SSFDWTVKLWTTKNNKPLYSFEDNSDYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTAS 564

  Fly   602 TVIDADIFYTTFKFTHCGRSLAVGNEAGNLLMLSF-EDMPFPPHFQYKQLKRAIFKALSMQPDLR 665
            ..::.:......::||.||.:|||:..|.:::... |.:..|.:.::.:..|.:.:..:.:.|..
  Rat   565 ISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVGEQIAVPRNDEWARFGRTLAEINASRADAE 629

  Fly   666 KQ 667
            ::
  Rat   630 EE 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13930	NP_647645.1	WD40	<279..648	CDD:225201	77/383 (20%)
		WD40 repeat	295..344	CDD:293791	10/49 (20%)
		WD40 repeat	350..397	CDD:293791	8/46 (17%)
		WD40 repeat	400..473	CDD:293791	13/72 (18%)
		WD40 repeat	478..513	CDD:293791	6/37 (16%)
		WD40	<518..>593	CDD:295369	18/84 (21%)
		WD40 repeat	524..560	CDD:293791	7/35 (20%)
Dync1i2	NP_446332.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..135		3/6 (50%)
		Interaction with DYNLT1. /evidence=ECO:0000269\|PubMed:27502274	133..165		6/31 (19%)
		Dynein_IC2	135..163	CDD:402922	5/27 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..209		10/57 (18%)
		WD 1	277..326		9/51 (18%)
		WD40 repeat	282..331	CDD:293791	10/51 (20%)
		WD40	329..>599	CDD:225201	63/304 (21%)
		WD 2	330..370		9/39 (23%)
		WD40 repeat	339..377	CDD:293791	7/37 (19%)
		WD 3	379..420		12/52 (23%)
		WD40 repeat	385..426	CDD:293791	11/55 (20%)
		WD 4	429..469		8/49 (16%)
		WD40 repeat	434..481	CDD:293791	11/56 (20%)
		WD 5	474..519		10/48 (21%)
		WD40 repeat	489..521	CDD:293791	7/35 (20%)
		WD40 repeat	527..565	CDD:293791	11/37 (30%)
		WD 6	568..607		9/38 (24%)
		WD40 repeat	573..599	CDD:293791	8/25 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54336
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820