DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RabX5 and RAB36

DIOPT Version :9

Sequence 1:	NP_647644.2	Gene:	RabX5 / 38209	FlyBaseID:	FBgn0035255	Length:	277	Species:	Drosophila melanogaster
Sequence 2:	XP_006724444.1	Gene:	RAB36 / 9609	HGNCID:	9775	Length:	370	Species:	Homo sapiens

Alignment Length:	219	Identity:	86/219 - (39%)
Similarity:	121/219 - (55%)	Gaps:	21/219 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLPQPPTVVLHDPRTHLRHLPPAYSAAQTPLSKERDFGAQVRYYL-EAPRKPK------------ 61
            |||.|.......|......:..:.:....|:|::|...:..::|. ||..:.:
Human    72 LLPLPELCHASQPSKDCGRMRSSLTPLGPPVSRDRVIASFPKWYTPEACLQLREHFHGQVSAACQ 136

  Fly    62 --------FRPCKVIFVGDCSVGKTAIVNRFCYDKFQSNYKATIGVDFELENFSILGHNYSLEMW 118
                    .:..||:.|||..||||::::|||.:.|..:||||||||||:|.|.|.|..|||::|
Human   137 RRNTGTVGLKLSKVVVVGDLYVGKTSLIHRFCKNVFDRDYKATIGVDFEIERFEIAGIPYSLQIW 201

  Fly   119 DTAGQERFRCIAGAYYRNASVIVVTYDMSKKDSLESAKKWLNSALNYNASKRPLVFLVGTKADLL 183
            ||||||:|:|||.||||.|.||:..:|::...:||..::||..||..|.:....:||||||.|||
Human   202 DTAGQEKFKCIASAYYRGAQVIITAFDLTDVQTLEHTRQWLEDALRENEAGSCFIFLVGTKKDLL 266

  Fly   184 SKEEFVRMERLAGLAAAELQAEYW 207
            |.....:.|..|...|.|:|||||
Human   267 SGAACEQAEADAVHLAREMQAEYW 290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RabX5	NP_647644.2	P-loop_NTPase	66..230	CDD:304359	75/142 (53%)
RabX5	NP_647644.2	RAB	66..225	CDD:197555	75/142 (53%)
RAB36	XP_006724444.1	P-loop_NTPase	148..290	CDD:304359	73/141 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152436
Domainoid	1	1.000	177	1.000	Domainoid score	I3604
eggNOG	1	0.900	-	-		E1_KOG0094
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3610
Inparanoid	1	1.050	190	1.000	Inparanoid score	I3888
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48903
OrthoDB	1	1.010	-	-		D1048146at2759
OrthoFinder	1	1.000	-	-		FOG0003705
OrthoInspector	1	1.000	-	-		otm40629
orthoMCL	1	0.900	-	-		OOG6_106322
Panther	1	1.100	-	-	O	PTHR47977
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8208
SonicParanoid	1	1.000	-	-		X2570
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800