Protein Alignment CG7974 and C9orf78

DIOPT Version :10

• Sequence 1: NP_647643.1
• Gene: CG7974 / 38207
• FlyBaseID: FBgn0035254
• Length: 294
• Species: Drosophila melanogaster
• Sequence 2: NP_057604.1
• Gene: C9orf78 / 51759
• HGNCID: 24932
• Length: 289
• Species: Homo sapiens
• Alignment Length: 293
• Identity: 147/293 - (50%)
• Similarity: 197/293 - (67%)
• Gaps: 28/293 - (9%)

  Fly    22 RKNLRQRKNSDEEEKEEQ------LTLDEIKERQRLRQRPNGVSLVGLALGKKIAPEEELAIKDP 80
            ||..|:|:...|.|::||      |.|:|.:|.|.||:||||||.|.|.:|:|: .||...:.||
Human     5 RKIFRRRRGDSESEEDEQDSEEVRLKLEETREVQNLRKRPNGVSAVALLVGEKV-QEETTLVDDP 68

  Fly    81 FNVKTGGLVNMKQLKS-GKMKEADDAYDVGIGTQFSAETNKRDEDEEMMKYIEQELQKRKGGGTE 144
            |.:||||:|:||:||. ||.|.:::. |:.:||.||||||:||||.:||||||.||:||||
Human    69 FQMKTGGMVDMKKLKERGKDKISEEE-DLHLGTSFSAETNRRDEDADMMKYIETELKKRKG---- 128

  Fly   145 DAAEDDGDVNKYLTPEDAALYALPDHLRQSSSHRSEEMLSNQMLNGIPEVDLGIVAKIRNIEATE 209
             ..|.:....|....|| .||.||:::|.||:.::|||||||||:|||||||||.|||:||.:||
Human   129 -IVEHEEQKVKPKNAED-CLYELPENIRVSSAKKTEEMLSNQMLSGIPEVDLGIDAKIKNIISTE 191

  Fly   210 EAKQKLLQDAKN-KKDGPSQFVPTNMAVNFMQHNRFNIED-NSDQRRRKREER-------EGNKS 265
            :||.:||.:.:| |||..:.|||||||||::|||||..|: |:..||.|.|.:       :..|.
Human   192 DAKARLLAEQQNKKKDSETSFVPTNMAVNYVQHNRFYHEELNAPIRRNKEEPKARPLRVGDTEKP 256

  Fly   266 AQHQTNPN----GVKRATDDYHYDKFRKQFRRY 294
            ...::.||    ..::|||||||:||:|..|||
Human   257 EPERSPPNRKRPANEKATDDYHYEKFKKMNRRY 289

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7974	NP_647643.1	Hep_59	113..214	CDD:462074	60/100 (60%)
C9orf78	NP_057604.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27		8/21 (38%)
		Interaction with SNRNP200. /evidence=ECO:0000269|PubMed:35241646, ECO:0007744|PDB:7OS2	5..58		24/52 (46%)
		Hep_59	101..196	CDD:462074	60/100 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	232..289		19/56 (34%)