DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7974 and C9orf78

DIOPT Version :9

Sequence 1:	NP_001261273.1	Gene:	CG7974 / 38207	FlyBaseID:	FBgn0035254	Length:	294	Species:	Drosophila melanogaster
Sequence 2:	NP_057604.1	Gene:	C9orf78 / 51759	HGNCID:	24932	Length:	289	Species:	Homo sapiens

Alignment Length:	293	Identity:	147/293 - (50%)
Similarity:	197/293 - (67%)	Gaps:	28/293 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 RKNLRQRKNSDEEEKEEQ------LTLDEIKERQRLRQRPNGVSLVGLALGKKIAPEEELAIKDP 80
            ||..|:|:...|.|::||      |.|:|.:|.|.||:||||||.|.|.:|:|: .||...:.||
Human     5 RKIFRRRRGDSESEEDEQDSEEVRLKLEETREVQNLRKRPNGVSAVALLVGEKV-QEETTLVDDP 68

  Fly    81 FNVKTGGLVNMKQLKS-GKMKEADDAYDVGIGTQFSAETNKRDEDEEMMKYIEQELQKRKGGGTE 144
            |.:||||:|:||:||. ||.|.:::. |:.:||.||||||:||||.:||||||.||:||||
Human    69 FQMKTGGMVDMKKLKERGKDKISEEE-DLHLGTSFSAETNRRDEDADMMKYIETELKKRKG---- 128

  Fly   145 DAAEDDGDVNKYLTPEDAALYALPDHLRQSSSHRSEEMLSNQMLNGIPEVDLGIVAKIRNIEATE 209
             ..|.:....|....|| .||.||:::|.||:.::|||||||||:|||||||||.|||:||.:||
Human   129 -IVEHEEQKVKPKNAED-CLYELPENIRVSSAKKTEEMLSNQMLSGIPEVDLGIDAKIKNIISTE 191

  Fly   210 EAKQKLLQDAKN-KKDGPSQFVPTNMAVNFMQHNRFNIED-NSDQRRRKREER-------EGNKS 265
            :||.:||.:.:| |||..:.|||||||||::|||||..|: |:..||.|.|.:       :..|.
Human   192 DAKARLLAEQQNKKKDSETSFVPTNMAVNYVQHNRFYHEELNAPIRRNKEEPKARPLRVGDTEKP 256

  Fly   266 AQHQTNPN----GVKRATDDYHYDKFRKQFRRY 294
            ...::.||    ..::|||||||:||:|..|||
Human   257 EPERSPPNRKRPANEKATDDYHYEKFKKMNRRY 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7974	NP_001261273.1	Hep_59	113..214	CDD:284467	60/100 (60%)
C9orf78	NP_057604.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27		8/21 (38%)
		Hep_59	101..196	CDD:399794	60/100 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	232..289		19/56 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148279
Domainoid	1	1.000	109	1.000	Domainoid score	I6400
eggNOG	1	0.900	-	-		E1_KOG3345
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9551
Inparanoid	1	1.050	247	1.000	Inparanoid score	I3274
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59632
OrthoDB	1	1.010	-	-		D1493869at2759
OrthoFinder	1	1.000	-	-		FOG0006447
OrthoInspector	1	1.000	-	-		oto88601
orthoMCL	1	0.900	-	-		OOG6_103943
Panther	1	1.100	-	-	LDO	PTHR13486
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4416
SonicParanoid	1	1.000	-	-		X5410
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800