DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Srrm234 and Srrm3

DIOPT Version :9

Sequence 1:	NP_001097475.2	Gene:	Srrm234 / 38206	FlyBaseID:	FBgn0035253	Length:	1655	Species:	Drosophila melanogaster
Sequence 2:	XP_038945678.1	Gene:	Srrm3 / 685890	RGDID:	1587868	Length:	669	Species:	Rattus norvegicus

Alignment Length:	1059	Identity:	207/1059 - (19%)
Similarity:	307/1059 - (28%)	Gaps:	459/1059 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 NGIGLTTPRGSGTNGHVQRNWACVRPGKKDKDYRAEDDTKKLDAQLNRPPNKEILDHDRKRKIEV 67
            ||.    |:..|::|    :|.           |||::.:..:..|.:..::|||||:|||::|:
  Rat    20 NGF----PQPGGSSG----SWP-----------RAEEELRAAEPGLVKRAHREILDHERKRRVEL 65

  Fly    68 KCLELEDILEKQGRTPEEIKSQVDSFRQKLMGQGKTDLAKDEFGRVANTTTSTATAAVRTTATAS 132
            ||:||::::|:||.:.|||:.:|.:|||.||.:
  Rat    66 KCMELQEMMEEQGYSEEEIRQKVGTFRQMLMEK-------------------------------- 98

  Fly   133 AATASTMTTTTEATTVKVAKPKKRRKRRKRAGHAITTTTTEKSAAISTPGSKTSSPRTQTG-EPA 196
                       |....|..:|         ..|.:..|                 ||...| ||.
  Rat    99 -----------EGVLTKEDRP---------GAHIVAET-----------------PRRMEGLEPG 126

  Fly   197 SSAPSATSNGARKTKAPYFQHDNREYLAKYESFRLTAHTWNYAAVARKFKPLRPALASGANKTRR 261
            ...|            |:.:.|.                           |:
  Rat   127 LEYP------------PFDEDDG---------------------------PV------------- 139

  Fly   262 PAVSKRTHPDCAC--ACQQKDPEPALEPAHR--TAEHSIQKELPSSQMKINIDGSVLLELLKYSS 322
                     ||.|  ||.:         .||  ..:|                         :||
  Rat   140 ---------DCDCPVACYR---------GHRGYRTKH-------------------------WSS 161

  Fly   323 SSLLGTLLGAGSAVATSARDTHQIAEAQQQKNARLREAFNISEYFVEGSSFDGDRKAKEDLAKSV 387
            ||
  Rat   162 SS--------------------------------------------------------------- 163

  Fly   388 ALQKELDAQRESLAAAAAAAAAGKDKETGKRYALVRTPSRERDRDAGDAAANGDERDHVSKTDKK 452
                                              ...|.:::.:..|              :.::
  Rat   164 ----------------------------------ASPPPKKKKKKKG--------------SHRR 180

  Fly   453 KRKKRARES-----SASPERKKKKKSKKHKKESKSKKKRSRKRKHSESGRDSDRDSDEEDDSSEE 512
            .||||..||     ||||.||||:..|||::                         |..|..|..
  Rat   181 SRKKRRLESECSCGSASPLRKKKRSVKKHRR-------------------------DRSDSGSRR 220

  Fly   513 ERRESKNVRKKAKKDKKKRDKKLKKKSRARASS----------------SDSERTNSPSRKENKS 561
            :||......|..:|:|.|..|:...:|..|.|.                |||...|..|.|....
  Rat   221 KRRYRSRSLKSKRKEKIKERKRPHTESPGRRSHHHSSVSSHSPSVSSHYSDSGSPNRLSPKHRDD 285

  Fly   562 DRSRGAKASKSDEK----------APQQENVMRSRSRERKDTRSSRPLEA-SIDSRQRKPR--ER 613
            .|..|::.|.....          :|||    ...||:|......||..| |...:...||  ::
  Rat   286 GRKTGSQRSSGSRSLSPSGGSGWGSPQQ----NGGSRQRSGAHGGRPGSAHSPPDKPSSPRACDK 346

  Fly   614 SAA--TPPRKEPERHRERSKDRQRSKEKHRSRDRLRSRERQRSRERQRSRERQRSKERQRSKERQ 676
            :||  |||        .|.||.|..:....|:.|........:|.|:|.|.|:||:....:..|
  Rat   347 AAAAPTPP--------ARGKDSQSPRSAPSSQGRGGRAAGGTARRRRRRRRRRRSRSSANAPRR- 402

  Fly   677 RSIERQRSKERQRSKERQRSRSKDALRCKEKPQCNEKERSRERRRSKSKDRQRSKEKHRPKDEQQ 741
                            |.|.|:|.|     .|:.:.:..|.....|.|......     |..|..
  Rat   403 ----------------RGRRRAKPA-----PPRGSSRSLSGAHSSSDSGGGAPG-----PGPEPG 441

  Fly   742 SVDKRRDRSTDRSKENQRSNERQRSKERQRSKERERSKDRQRSRERRRSKEGQLSKDRQGLKERQ 806
            |             |.......:|:|||........:.....:..||...||..|....|.....
  Rat   442 S-------------ERGHGGHGKRAKERPPRARPASTSPSPGAHGRRGGPEGNSSSRSPGPHPGS 493

  Fly   807 RSNERKRSKERQPSKEKQRSRERQRSREPLQSKDRQRSKERQ-RSRERPAKEARPTRSPRERSSK 870
            .|:.|..||.|..|.:|   |.|..|..|...|...|.|:.: |:|...|:.||..|  |.||..
  Rat   494 WSSSRSPSKSRSRSPDK---RTRSPSLSPSPKKPLGRDKDSEGRARHAEAEAARTRR--RSRSYS 553

  Fly   871 SRDDRRHRSPTNASRKQKDDTKLSRNARFKS--PAHSPEAPPKKSVPTPAFNPFKAAEDTVNDIL 933
            ....||..||:     ..:..:::|....:.  ||..|..|.....|:....| ||:    :.:|
  Rat   554 PIRKRRRDSPS-----FMEPRRITRKLLLRGLWPAWGPCGPGSTGSPSDTHCP-KAS----HPLL 608

  Fly   934 GTKSVMV--ALEQTKRQRAASSSSSDSDSSGSSSTSSRTPSPKPTPRKQKKRSKTPELKEVKKEI 996
            ..:.::.  .|||...|                    ..|..:|.|..|..:.:.|:.::.:..:
  Rat   609 PAQPLLFLQLLEQRLLQ--------------------PEPQQEPKPWAQPWKLQQPQSRDSQPFL 653

  Fly   997 SPRKESRVSVKREQSNSPQ 1015
            ...:|       .||..||
  Rat   654 QRLQE-------PQSQLPQ 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Srrm234	NP_001097475.2	cwf21	58..98	CDD:285507	20/39 (51%)
		MIP-T3	672..>936	CDD:287245	61/266 (23%)
		SRRM_C	<1584..1610	CDD:291883
Srrm3	XP_038945678.1	cwf21_SRRM3	34..101	CDD:410602	30/109 (28%)
Srrm3	XP_038945678.1	SRRM_C	527..572	CDD:405827	15/51 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1869
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	3	2.860