DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Srrm234 and Srrm3

DIOPT Version :9

Sequence 1:	NP_001097475.2	Gene:	Srrm234 / 38206	FlyBaseID:	FBgn0035253	Length:	1655	Species:	Drosophila melanogaster
Sequence 2:	NP_067378.2	Gene:	Srrm3 / 58212	MGIID:	1920309	Length:	648	Species:	Mus musculus

Alignment Length:	1022	Identity:	210/1022 - (20%)
Similarity:	306/1022 - (29%)	Gaps:	440/1022 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 NG-IGLTTPRGSGTNGHVQRNWACVRPGKKDKDY-RAEDDTKKLDAQLNRPPNKEILDHDRKRKI 65
            || .|:..| ....||..|       ||.....: |||::.:..:..|.:..::|||||:|||::
Mouse     7 NGATGMPAP-PDAANGFPQ-------PGASSGSWPRAEEELRAAEPGLVKRAHREILDHERKRRV 63

  Fly    66 EVKCLELEDILEKQGRTPEEIKSQVDSFRQKLMGQGKTDLAKDEFGRVANTTTSTATAAVRTTAT 130
            |:||:||::::|:||.:.|||:.:|.:|||.||.:
Mouse    64 ELKCMELQEMMEEQGYSEEEIRQKVGTFRQMLMEK------------------------------ 98

  Fly   131 ASAATASTMTTTTEATTVKVAKPKKRRKRRKRAGHAITTTTTEKSAAISTPGSKTSSPRTQTG-E 194
                         |....:..:|         ..|.:..|                 ||...| |
Mouse    99 -------------EGVLTREDRP---------GAHIVAET-----------------PRRMEGLE 124

  Fly   195 PASSAPSATSNGARKTKAPYFQHDNREYLAKYESFRLTAHTWNYAAVARKFKPLRPALASGANKT 259
            |....|            |:.:.|.                           |:
Mouse   125 PGLEYP------------PFDEDDG---------------------------PV----------- 139

  Fly   260 RRPAVSKRTHPDCAC--ACQQKDPEPALEPAHR--TAEHSIQKELPSSQMKINIDGSVLLELLKY 320
                       ||.|  :|.:         .||  ..:|                         :
Mouse   140 -----------DCDCPVSCYR---------GHRGYRTKH-------------------------W 159

  Fly   321 SSSSLLGTLLGAGSAVATSARDTHQIAEAQQQKNARLREAFNISEYFVEGSSFDGDRKAKEDLAK 385
            ||||
Mouse   160 SSSS------------------------------------------------------------- 163

  Fly   386 SVALQKELDAQRESLAAAAAAAAAGKDKETGKRYALVRTPSRERDRDAGDAAANGDERDHVSKTD 450
                                                ...|.:::.:..|              :.
Mouse   164 ------------------------------------ASPPPKKKKKKKG--------------SH 178

  Fly   451 KKKRKKRARES-----SASPERKKKKKSKKHKKESKSKKKRSRKRKHSESGRDSDRDSDEEDDSS 510
            ::.||||..||     ||||.|||||..|||::                         |..|..|
Mouse   179 RRSRKKRRLESECSCGSASPLRKKKKNVKKHRR-------------------------DRSDSGS 218

  Fly   511 EEERRESKNVRKKAKKDKKKRDKKLKKKSRAR-------------ASSSDSERTNSPSR------ 556
            ..:||......|..:|:|.|..|:...:|..|             :.||....:.||||
Mouse   219 RRKRRYRSRSLKSKRKEKNKERKRPHTESPGRRFHHHSSASSHSPSMSSHYSDSGSPSRLSPKHR 283

  Fly   557 ---KENKSDRSRGAKASK----SDEKAPQQENVMRSRSRERKDTRSSRPLEA-SIDSRQRKPR-- 611
               ::..|.||.|:::..    |...:|||    ...||:|......||..| |...:...||
Mouse   284 DDGRKTGSQRSSGSRSPSPSGGSGWGSPQQ----NGGSRQRSGAHGGRPGSAHSPPDKPSSPRAC 344

  Fly   612 ERSAA--TPPRKEPERHRERSKDRQRSKEKHRSRDRLRSRERQRSRERQRSRERQRSKE-----R 669
            :::||  |||        .|.||.|..:....|:.|........:|.|:|.|.|:||:.     |
Mouse   345 DKAAAAPTPP--------ARGKDSQSPRSAPSSQGRGGRAAGGTARRRRRRRRRRRSRSSANAPR 401

  Fly   670 QRSKERQRSIERQRSKERQRSKERQRSRSKDALRCKEKPQCNEKERSRERRRSKSKDRQRSKEKH 734
            :|.:.|.:... .|...|..|.....|.|...........|:|:......:|:|.:     ..:.
Mouse   402 RRGRRRTKPAP-PRGSSRSLSGAHSSSDSGGGAPGPGPEPCSERGHGGHGKRAKER-----PPRA 460

  Fly   735 RPKDEQQSVDKRRDRSTDRSKENQRS---NERQRSKERQRSKERERSKD-RQRSRERRRSKEGQL 795
            ||.....|...|..|.......:.||   ::...|..|..||...||.| |.||.....|.:..|
Mouse   461 RPASTSPSPGTRGRRGGPEGNSSSRSPGPHQGSWSSSRSPSKSHSRSPDKRTRSPSLSPSPKKPL 525

  Fly   796 SKDRQGLKERQRSNERKRSKERQPSKEKQRSRERQRSREPLQSKDRQRSK--ERQR---SRERPA 855
            .:|:.           ...:.|....|..|:|.|.||..|::.:.|....  |.:|   :|:||.
Mouse   526 GRDKD-----------SEGRARHAEAEAARTRRRSRSYSPIRKRRRDSPSFMEPRRITSARKRPI 579

  Fly   856 KEARPTRSPRERSSKSRDDRRHRSPTNASRKQKDDTKLSRNARFKSPAHSPEAPPKKSVPTPAFN 920
            ...||  ||...||....|...||                ::|..||.||..:...:|
Mouse   580 PYYRP--SPSSSSSCLSTDYSSRS----------------HSRSPSPGHSHGSYSSRS------- 619

  Fly   921 PFKAAEDTVNDILGTKSVMVALEQTKRQRAASSSSSDSDSSGSSSTS 967
                        .||:|         |..:||.|.|.|..|.|||.|
Mouse   620 ------------HGTRS---------RSCSASRSRSPSYHSRSSSES 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Srrm234	NP_001097475.2	cwf21	58..98	CDD:285507	20/39 (51%)
		MIP-T3	672..>936	CDD:287245	60/272 (22%)
		SRRM_C	<1584..1610	CDD:291883
Srrm3	NP_067378.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44		12/44 (27%)
		cwf21_SRRM3	34..101	CDD:410602	30/109 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	99..139		12/104 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..648		153/728 (21%)
		SRRM_C	527..583	CDD:405827	15/66 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1869
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.860