DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Srrm234 and Srrm2

DIOPT Version :9

Sequence 1:	NP_001097475.2	Gene:	Srrm234 / 38206	FlyBaseID:	FBgn0035253	Length:	1655	Species:	Drosophila melanogaster
Sequence 2:	NP_001264083.1	Gene:	Srrm2 / 302969	RGDID:	1310163	Length:	2707	Species:	Rattus norvegicus

Alignment Length:	2060	Identity:	461/2060 - (22%)
Similarity:	689/2060 - (33%)	Gaps:	775/2060 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYNGIGLTTPRGSGTNGHVQRNWACVRPGKKDK-DYRAEDDTKKLDAQLNRPPNKEILDHDRKRK 64
            |||||||.|||||||||:||||.:.||..:.:: ||:.|::.::|:|.|.:.||.:||||:|||:
  Rat     1 MYNGIGLPTPRGSGTNGYVQRNLSLVRGRRGERPDYKGEEELRRLEAALVKRPNPDILDHERKRR 65

  Fly    65 IEVKCLELEDILEKQGRTPEEIKSQVDSFRQKLMGQGKTDLAKDEFGRVANTTTSTATAAVRTTA 129
            :|::|||||:::|:||...::|:.:|.:||..|       |.||
  Rat    66 VELRCLELEEMMEEQGYEEQQIQEKVATFRLML-------LEKD--------------------- 102

  Fly   130 TASAATASTMTTTTEATTVKVAKPKKRRKRRKRAGHAITTTTTEKSAAISTPGSKTSSPRTQTGE 194
                                                             ..||.|..:|
  Rat   103 -------------------------------------------------VNPGGKEETP------ 112

  Fly   195 PASSAPSATSNGARKTKAPYFQHDNREYLAKYESFRLTAHTWNYAAVARKFKPLRPALASGANKT 259
                                                                            .
  Rat   113 ----------------------------------------------------------------G 113

  Fly   260 RRPAVSKRTHPDCACACQQKDPEPALEPAHRTAEHSIQKELPSSQMKINIDGSVLLELLKYSSSS 324
            :||.|:
  Rat   114 QRPVVT----------------------------------------------------------- 119

  Fly   325 LLGTLLGAGSAVATSARDTHQIAEAQQQKNARLREAFNISEYFVEGSSFDGDRKAKEDLAKSVAL 389
                             :|||:||..::||.|||.||.||:.:|:|||||..|:|:|  ||..|
  Rat   120 -----------------ETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRRARE--AKQTA- 164

  Fly   390 QKELDAQRESLAAAAAAAAAGKDKETGKRYALVRTPSRERDRDAGDAAANGDERDHVSKTDKKKR 454
                                   .|..|.|:|||..|..|                 |.|.|:|:
  Rat   165 -----------------------PEPPKPYSLVRETSSSR-----------------SPTPKQKK 189

  Fly   455 KKR-----ARESSASP--ERKKKKKSKKHKKESKSKKKRSR-------------KRKHSES---- 495
            ||:     .|..|:||  ||||..|.|||:.||:|||::.|             |||.|.|
  Rat   190 KKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPA 254

  Fly   496 ------GRDSDRDSDEEDDSSEEERRE--------------------------------SKNVRK 522
                  .|.:..||....|:|....|.                                :.|:::
  Rat   255 PKSRRAHRSTSADSASSSDTSRSRSRSAAAKIHTTSLTGQSPPLASGHQGEVDAPSEPGATNIQQ 319

  Fly   523 KAKKDKKKR-------DKKLKKKSRARASSS----------------------DSER-------T 551
            .:..|...:       ||..|:||..|.|.|                      ||.|       :
  Rat   320 PSSPDPSTKQSSSPYEDKDKKEKSAVRPSPSPERSSTGPELPAPTPLLVEQHGDSPRPLAAIPSS 384

  Fly   552 NSPSRKENKSDRSRGAKASKSDEKAPQQENVMRSRSRERKDTRSSRPLEASIDSRQRKP---RER 613
            ..|....:::..:||....||.||.||..: ..|.....:.|:.||...:|.:|.:..|   ..|
  Rat   385 QEPVNPSSEASPTRGCSPPKSPEKPPQSSS-SESCPPSPQPTKLSRHASSSPESLKPTPAPGSRR 448

  Fly   614 SAATPPRKEPERHRERSKDRQRS-KEKHRS-RDRLRSRERQRSRER---QRSRERQRSKERQRSK 673
            ..::.|..:...|....:|:..| ...||: |.|..:.:|.|||.|   :|...|.||.:.:||:
  Rat   449 EISSSPTSKNRSHGRAKRDKSHSHTPSHRAGRSRSPATKRGRSRSRTPTKRGHSRSRSPQWRRSR 513

  Fly   674 ERQRSIERQRSKERQRSKERQR---SRSKDALRCKEKPQCNEKERSRERRRSKSKDRQ-----RS 730
            ..||..:.:..:.|.||:..||   |||::..|         :.|||..||.:|..|.     ||
  Rat   514 SAQRWGKSRSPQRRGRSRSPQRPGWSRSRNTQR---------RGRSRSARRGRSHSRSPATRGRS 569

  Fly   731 KEK---HRPKDEQQSVDKRRDRSTDRSKENQRSNE-----RQRSKERQRSKERERSKDRQRSRER 787
            :.:   .|.:...::..:||.||...::...||..     |.||:...|.:.|.||..|:|||.|
  Rat   570 RSRTPARRGRSRSRTPARRRSRSRTPARRRSRSRTPARRGRSRSRTPTRRRSRTRSPVRRRSRSR 634

  Fly   788 RRSKEGQLSKDRQGLKERQRSNERK-----RSKERQPSKEKQRSRE-------RQRSREPLQSKD 840
            .:::....|:.|...:...||..|.     ||:.|.|::...|||.       |.|||.|.:.:.
  Rat   635 SQARRSGRSRSRTPARRSGRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPARRRS 699

  Fly   841 RQRSKERQ-RSRERPAKEARPTRSPRERSSKSRDDRRHRSPTNASRKQKDDTKLSRNAR-FKSP- 902
            |.||..|: ||..|..:....:.|..||.:|||..:| ||.:|:|.:.|.....||.:| ..||
  Rat   700 RSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQR-RSRSNSSPEMKKSHVSSRRSRSLSSPR 763

  Fly   903 ---------------------------AHSPEAPPK-KSVPTPAFNPFKAAEDTVNDILGTKSVM 939
                                       :.|..:||| ||...|..:...:.:..|......:|..
  Rat   764 SKAKSLRRSLSGSSPCPKQKSQTPTRRSRSGSSPPKQKSKTPPRQSRSNSPQPKVKSGTPPRSGS 828

  Fly   940 VALEQTKRQRAASSSSSDSDSSGSSSTSSRTP--------SPK----PTPRKQKKRSKTPELKEV 992
            |...|.:.........|.|:||......||||        ||:    ..||:...||.:|:.| |
  Rat   829 VTNMQAEECSTTPQRQSHSESSPDGEVKSRTPSRQSCSGSSPRVKSSTPPRQSPSRSSSPQPK-V 892

  Fly   993 KKEISPRKESRVSVKREQSNSPQKSKSKSKVDESSPKRTSR----------------RSRSISSE 1041
            |..||||:.|..|     |:||    |.|:|...:|:|.||                ||||.|.:
  Rat   893 KAVISPRRRSHSS-----SSSP----SPSRVTSRTPQRKSRSVSPCPKVDSRLLRHSRSRSSSPD 948

  Fly  1042 --------LRYS---------------PAERH--------PERYHD------------------- 1056
                    ||:|               |.:::        |::..|
  Rat   949 TKMELGTPLRHSHSGSTSPYPKSMLQTPPDQNLSGSKSPCPQKSRDSPTGSSGSFSLCPGVTPSS 1013

  Fly  1057 -----------IVQDKKRPS--------KVREAHSTKP------------------APVVRLRAQ 1084
                       .||.|.:..        :||:.|...|                  :||..|.|:
  Rat  1014 ILPGESSFSSSFVQQKGQSQTWPDTSSPEVRQMHLESPSLQSKSQTSPKGGLSRSSSPVTELTAR 1078

  Fly  1085 S---DDGSDAETG-----------------------VDGAALEEFQQSRREREEQQE-LRMLEQL 1122
            |   .|.|:..|.                       ||..:|  ..|||.|..|.:| |.::|:
  Rat  1079 SPVKQDKSELSTDPKLKSGMSPEQNKTKPDSSLYPLVDSKSL--LVQSRLEPSELKERLGLIEE- 1140

  Fly  1123 KSGIAAKA-------------------KQKIKIMEKDPAKEGSEVSGSDQVTATKRNSLSEFLVA 1168
              .:|:..                   |...:::.|:.:..||.....||......:|..|.:..
  Rat  1141 --DVASSCVLRDKFSPTQDRPESSTVLKDTPRVLLKERSGAGSPPGTRDQKILLPNSSQDELMEV 1203

  Fly  1169 NNVTALINTLTTTTVTLTTTPPPPLAVVVPLEQRQEQPQ-----QRDPDRELSVPVEDTVKKRDT 1228
            ..                  ...||:.|:|....:.:..     :..|:.|.|..|..|:.:..:
  Rat  1204 EK------------------SEQPLSQVLPTLSPEHKEMSASNFESSPEIEESPAVLSTLDQSQS 1250

  Fly  1229 STPPICKTPQVTA--NGDAKSPTLVHKNHVHHNRPPPQHMHHHSQQQQHHQHPPGKRIFHNRTLN 1291
            ......:.|.|.:  .|...||.  ||...|                    .||....|.:....
  Rat  1251 QPSKAAEIPAVASCWVGPQVSPE--HKELSH--------------------SPPRDNSFESLEFR 1293

  Fly  1292 N-----------NPNSRHSTNNPHACGGGGVPHSN-SNSSNSGGNNNNAAMLPFLAGTPGTYNRT 1344
            |           :|..:...|.|........|..: ...|......:::.:.|.:....|.:
  Rat  1294 NSGPVLEVNTDFSPEVKEELNGPFLNQTETDPSLDMKEQSTRSSRRSSSELSPEIVEKVGIF--- 1355

  Fly  1345 TNRLNHGPLLTATHYNICKNHQHSLQQQQAHHLARGLVYNSALFGHGQRHPGLLSLTGAGVGMSG 1409
            :::....|||            .::||:.........|.:..|.....|.|...|.:|:.
  Rat  1356 SSQSVSSPLL------------ETVQQRTPSRERSSSVSSPELKDGLPRTPSRRSRSGSS----- 1403

  Fly  1410 PGAPLLGHPSHVRGGGGPISFNAAAAAAAVAANSISYLHHHHQHQQKPKIVIKP----FKIHDP- 1469
                    |....|.|.|...:.:.::..:.....:......:....|:....|    .:.|.|
  Rat  1404 --------PRLRDGSGTPSRHSLSGSSPGIKETPQTPSRGRSECDSSPEPKALPQTPRARSHSPS 1460

  Fly  1470 ------QPLVAALADSSLVDAIVSKVSTATVAAAESAARRSRS--------------RERR---- 1510
                  :.:......|....::..|..|.|     |..:||||              :||.
  Rat  1461 SPERNNKSVTPQRERSGSESSVEQKTLTRT-----SPGQRSRSGSSQELDGKPSVSPQERSESDS 1520

  Fly  1511 ---SRSKRRTSTSHHRHDSSS---ESRSRYSSSSSRSGS-----------HSSRSGSHSS----- 1553
               |:.|.||......|..||   :|:||:|...|||||           ..::||:.||
  Rat  1521 SPDSKPKARTPLRQRSHSGSSPEVDSKSRHSPRLSRSGSSPEMKEKSRVLQRAQSGTDSSPEHKI 1585

  Fly  1554 -------RTSCSTNSSSGSSSSGSGSGSSQSGSRSPSIPR--RRGSPSFLDRRRITSARKRPIPY 1609
                   |.|.|.:||.....|..||.||:|....|...|  ||||.|.::.:    .:.|..|.
  Rat  1586 PAPRALPRRSRSGSSSKERGPSPEGSSSSESSPEHPPKSRTARRGSRSSVEPK----TKSRTPPR 1646

  Fly  1610 HHKANAEGEVEDASSCCSSCFSRASSPATPLLTPLRNSRSPSMAA 1654
            ...:.:..|:...:.......|.:|||.|...||.|..||||:::
  Rat  1647 RRSSRSSPELTRKARVSRRSRSASSSPETRSRTPPRRRRSPSVSS 1691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Srrm234	NP_001097475.2	cwf21	58..98	CDD:285507	18/39 (46%)
		MIP-T3	672..>936	CDD:287245	89/322 (28%)
		SRRM_C	<1584..1610	CDD:291883	8/27 (30%)
Srrm2	NP_001264083.1	cwf21_SRRM2	39..102	CDD:410601	28/69 (41%)
		PHA03307	292..>609	CDD:223039	76/326 (23%)
		PHA03247	<1985..2442	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	263	1.000	Domainoid score	I1867
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	260	1.000	Inparanoid score	I3039
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003470
OrthoInspector	1	1.000	-	-		oto98577
orthoMCL	1	0.900	-	-		OOG6_102153
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950