DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Srrm234 and SRRM2

DIOPT Version :9

Sequence 1:	NP_001097475.2	Gene:	Srrm234 / 38206	FlyBaseID:	FBgn0035253	Length:	1655	Species:	Drosophila melanogaster
Sequence 2:	NP_057417.3	Gene:	SRRM2 / 23524	HGNCID:	16639	Length:	2752	Species:	Homo sapiens

Alignment Length:	2076	Identity:	479/2076 - (23%)
Similarity:	703/2076 - (33%)	Gaps:	766/2076 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYNGIGLTTPRGSGTNGHVQRNWACVRPGKKDK-DYRAEDDTKKLDAQLNRPPNKEILDHDRKRK 64
            |||||||.|||||||||:||||.:.||..:.:: ||:.|::.::|:|.|.:.||.:||||:|||:
Human     1 MYNGIGLPTPRGSGTNGYVQRNLSLVRGRRGERPDYKGEEELRRLEAALVKRPNPDILDHERKRR 65

  Fly    65 IEVKCLELEDILEKQGRTPEEIKSQVDSFRQKLMGQGKTDLAKDEFGRVANTTTSTATAAVRTTA 129
            :|::|||||:::|:||...::|:.:|.:||..|       |.||
Human    66 VELRCLELEEMMEEQGYEEQQIQEKVATFRLML-------LEKD--------------------- 102

  Fly   130 TASAATASTMTTTTEATTVKVAKPKKRRKRRKRAGHAITTTTTEKSAAISTPGSKTSSPRTQTGE 194
                                                             ..||.|..:|
Human   103 -------------------------------------------------VNPGGKEETP------ 112

  Fly   195 PASSAPSATSNGARKTKAPYFQHDNREYLAKYESFRLTAHTWNYAAVARKFKPLRPALASGANKT 259
                                                                            .
Human   113 ----------------------------------------------------------------G 113

  Fly   260 RRPAVSKRTHPDCACACQQKDPEPALEPAHRTAEHSIQKELPSSQMKINIDGSVLLELLKYSSSS 324
            :||||:
Human   114 QRPAVT----------------------------------------------------------- 119

  Fly   325 LLGTLLGAGSAVATSARDTHQIAEAQQQKNARLREAFNISEYFVEGSSFDGDRKAKEDLAKSVAL 389
                             :|||:||..::||.|||.||.||:.:|:|||||..|:|:|  ||..|
Human   120 -----------------ETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRRARE--AKQPA- 164

  Fly   390 QKELDAQRESLAAAAAAAAAGKDKETGKRYALVRTPSRERDRDAGDAAANGDERDHVSKTDKKKR 454
                                   .|..|.|:|||..|..|                 |.|.|:|:
Human   165 -----------------------PEPPKPYSLVRESSSSR-----------------SPTPKQKK 189

  Fly   455 KKR-----ARESSASP--ERKKKKKSKKHKKESKSKKKRSR-------------KRKHSES---- 495
            ||:     .|..|:||  ||||..|.|||:.||:|||::.|             |||.|.|
Human   190 KKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPA 254

  Fly   496 ------GRDSDRDSDEEDDSSEEERRES------------------------------------- 517
                  .|.:..||....|:|....|.:
Human   255 PKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQ 319

  Fly   518 -----KNVRKKAKKDKKKRDKKLKKKSRARASSS------------------------------- 546
                 :...|:.....:.:||..|:||..|.|.|
Human   320 RPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATT 384

  Fly   547 --DSERTNSPSRKENKSDRSRGAKASKSDEKAPQQENVMRSRSRERKDTRSSRPLEASIDSRQRK 609
              ..|..|.||......|||    ..||.||.||..: ..|.....:.|:.||...:|.:|.:..
Human   385 PLSQEPVNPPSEASPTRDRS----PPKSPEKLPQSSS-SESSPPSPQPTKVSRHASSSPESPKPA 444

  Fly   610 P---RERSAATPPRKEPERHRERSKDRQRSKEKHRSRDRLRS---RERQRSRER---QRSRERQR 665
            |   ..|..::.|..:...|....:|:..|....|...|.||   .:|.|||.|   :|...|.|
Human   445 PAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSR 509

  Fly   666 SKERQRSKERQRSIERQRSKERQ-RSKERQR---SRSKDALRCKEKPQCNEKERSRERRRSKSKD 726
            |.:.:||:..|| ..|.||.:|: ||:..||   |||::..|         :.|||..||.:|..
Human   510 SPQWRRSRSAQR-WGRSRSPQRRGRSRSPQRPGWSRSRNTQR---------RGRSRSARRGRSHS 564

  Fly   727 RQ-----RSKEK---HRPKDEQQSVDKRRDRSTDRSKENQRSNE-----RQRSKERQRSKERERS 778
            |.     ||:.:   .|.:...::..:||.||...::...||..     |.||:...|.:.|.||
Human   565 RSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARRRSRTRS 629

  Fly   779 KDRQRSRERRRSKEGQLSKDRQGLKE-RQRSN---ERKRSKERQPSKEKQRSRE-------RQRS 832
            ..|:|||.|..::....|:.|...:. |.||.   .|.||:.|.|::...|||.       |.||
Human   630 PVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRS 694

  Fly   833 REPLQSKDRQRSKERQ-RSRERPAKEARPTRSPRERSSKSRDDRRHRSPTNASRKQKDDTKLSRN 896
            |.|.:.:.|.||..|: ||..|..:....:.|..||.:|||..:| ||.:|:|.:.|.....||.
Human   695 RTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQR-RSRSNSSPEMKKSRISSRR 758

  Fly   897 A------------------------------------RFKSPAHSPEA---------------PP 910
            :                                    |.:|.:..|:|               ||
Human   759 SRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPP 823

  Fly   911 KKSVPTP------AFNPFKAAEDTVNDILGTKSVMVALEQ--TKRQRAASSSSSD--------SD 959
            |:...||      :.:|....:.......|:.:...|.||  |.::|:...||.|        |.
Human   824 KQKSKTPSRQSHSSSSPHPKVKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKSRTPSR 888

  Fly   960 SSGSSSTSSRTPSPKPTPRKQKKRSKTPELKEVKKEISPRKESRVSVKREQSNSPQKSKSKSKVD 1024
            .|.|.|:..|..|..| ||:...||.:|:.| ||..|||         |::|:|...|.|.|:|
Human   889 HSCSGSSPPRVKSSTP-PRQSPSRSSSPQPK-VKAIISP---------RQRSHSGSSSPSPSRV- 941

  Fly  1025 ESSPKRTSRRSRSISS----ELRYSPAERH-----PERYHDIVQDKKRP-SKVREAHSTKPAPVV 1079
              :.:.|.|||||:|.    |.|..|...|     |:       .|.:| :..|::||...:|..
Human   942 --TSRTTPRRSRSVSPCSNVESRLLPRYSHSGSSSPD-------TKVKPETPPRQSHSGSISPYP 997

  Fly  1080 RLRAQSDDG---------------------------------------SDAETGVDGAALEEFQQ 1105
            :::||:..|                                       .::..||....|:...|
Human   998 KVKAQTPPGPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQSQ 1062

  Fly  1106 S-------------RREREEQQELRMLEQL--KSGIAAKAKQKIKIMEKDPAKEG-SEVSGSDQV 1154
            :             |:...|...|:...|.  |.|.:..:....::..:.|.::. .|.|.|..:
Human  1063 TSPDHRSDTSSPEVRQSHSESPSLQSKSQTSPKGGRSRSSSPVTELASRSPIRQDRGEFSASPML 1127

  Fly  1155 TATKRNSLSEF---------LVANNVTALINTLTTTTVTLTTTPPPPLAVVVPLEQR-------- 1202
            .:......|.|         :.:|::.......|..:......||...|...|..|:
Human  1128 KSGMSPEQSRFQSDSSSYPTVDSNSLLGQSRLETAESKEKMALPPQEDATASPPRQKDKFSPFPV 1192

  Fly  1203 QEQPQQ--------RDPDRELSVPVEDTVKKRDTSTPPICKTPQVTANGDAKSPTLVHKNHVHHN 1259
            |::|:.        |.|.||.|........|...|..|       |::.|.:...:|.|:    .
Human  1193 QDRPESSLVFKDTLRTPPRERSGAGSSPETKEQNSALP-------TSSQDEELMEVVEKS----E 1246

  Fly  1260 RPPPQHMHHHSQQ-----QQHHQHPP--GKRIFHNRTLNNNPN--SRHSTNNPHACGGGGVPH-- 1313
            .|..|.:.|.|.:     ..:.:..|  .:|...:.||:.:.:  |..:...|......|.||
Human  1247 EPAGQILSHLSSELKEMSTSNFESSPEVEERPAVSLTLDQSQSQASLEAVEVPSMASSWGGPHFS 1311

  Fly  1314 ------SNS----NS-------SNSG--GNNNNAAML---------PFL---------------- 1334
                  |||    ||       .|||  |...|....         |||
Human  1312 PEHKELSNSPLRENSFGSPLEFRNSGPLGTEMNTGFSSEVKEDLNGPFLNQLETDPSLDMKEQST 1376

  Fly  1335 --AG------TPGTYNR---TTNRLNHGPLLTATHYNICKNHQHSLQQQQAHHLARGLVYNSALF 1388
              :|      :|....:   ::|:....|:|.|......:....|....:   :..||
Human  1377 RSSGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRERSSSASSPE---MKDGL------- 1431

  Fly  1389 GHGQRHPGLLSLTGAGVGM-SGPGAPLLGHPSHVRGGGGPISFNAAAAAAAVAANSISYLHHHHQ 1452
               .|.|...|.:|:..|: .|.|.|    ..|...|..|...:.....:...:...|
Human  1432 ---PRTPSRRSRSGSSPGLRDGSGTP----SRHSLSGSSPGMKDIPRTPSRGRSECDS------- 1482

  Fly  1453 HQQKPKIVIKPFKIHDPQPLVAALADSSLV-----DAIVSKVSTATVAAAESAARRSRS------ 1506
             ..:||.:.:..:.....|....|.:..|.     ....|.|...|||.. ...:||||
Human  1483 -SPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVART-PLGQRSRSGSSQEL 1545

  Fly  1507 --------RERR-------SRSKRRTSTSHHRHDSSS---ESRSRYSSSSSRSGSH--------- 1544
                    :||.       |::|.||.........||   :|:||.|...|||||.
Human  1546 DVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRA 1610

  Fly  1545 --SSRSGSHSS------------RTSCSTNSSSGSSSSGSGSGSSQSGSRSPSIPR--RRGSPSF 1593
              .::|||.||            |.|.|.:||.|...|..||.|::|....|...|  ||||.|.
Human  1611 APRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSS 1675

  Fly  1594 LDRRRITSARKRPIPYHHKANAEGEVEDASSCCSSCFSRASSPATPLLTPLRNSRSPSMAA 1654
            .:.:    .:.|..|....:.:..|:...:.......|.:|||.|...||.|:.||||:::
Human  1676 PEPK----TKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSS 1732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Srrm234	NP_001097475.2	cwf21	58..98	CDD:285507	18/39 (46%)
		MIP-T3	672..>936	CDD:287245	93/349 (27%)
		SRRM_C	<1584..1610	CDD:291883	8/27 (30%)
SRRM2	NP_057417.3	cwf21_SRRM2	39..102	CDD:410601	28/69 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	141..2131		405/1713 (24%)
		Sufficient for RNA-binding	197..259		23/61 (38%)
		PHA03307	293..>600	CDD:223039	77/321 (24%)
		PRK14971	<313..>411	CDD:237874	18/101 (18%)
		PRK07003	<2195..>2452	CDD:235906
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2311..2342
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2389..2752
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	259	1.000	Domainoid score	I2002
eggNOG	1	0.900	-	-		E1_KOG1869
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	294	1.000	Inparanoid score	I2773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003470
OrthoInspector	1	1.000	-	-		oto91500
orthoMCL	1	0.900	-	-		OOG6_102153
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R267
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.840