Protein Alignment Srrm234 and SRRM3

DIOPT Version :10

• Sequence 1: NP_001097475.2
• Gene: Srrm234 / 38206
• FlyBaseID: FBgn0035253
• Length: 1655
• Species: Drosophila melanogaster
• Sequence 2: NP_001278760.1
• Gene: SRRM3 / 222183
• HGNCID: 26729
• Length: 674
• Species: Homo sapiens
• Alignment Length: 884
• Identity: 193/884 - (21%)
• Similarity: 281/884 - (31%)
• Gaps: 347/884 - (39%)

  Fly     3 NGIGLTTPRGSGTNGHVQRNWACVRPGKKDKDYRAEDDTKKLDAQLNRPPNKEILDHDRKRKIEV 67
            ||.    |:.|.::|    .|.           |||::.:..:..|.:..::|||||:|||::|:
Human    20 NGF----PQPSSSSG----TWP-----------RAEEELRAAEPGLVKRAHREILDHERKRRVEL 65

  Fly    68 KCLELEDILEKQGRTPEEIKSQVDSFRQKLMGQGKTDLAKDEFGRVANTTTSTATAAVRTTATAS 132
            ||:||::::|:||.:.|||:.:|.:|||.||.:
Human    66 KCMELQEMMEEQGYSEEEIRQKVGTFRQMLMEK-------------------------------- 98

  Fly   133 AATASTMTTTTEATTVKVAKPKKRRKRRKRAGHAITTTTTEKSAAISTPGSKTSSPR-TQTGEPA 196
                       |....:..:|         .||.:..|                 || |:..||.
Human    99 -----------EGVLTREDRP---------GGHIVAET-----------------PRLTEGAEPG 126

  Fly   197 -SSAPSATSNGARKTKAP---YFQHDNREYLAKYESFRLTAHTWNYAAVARKFKPLRPALASGAN 257
             ..||....:|......|   |..|  |.|..|:         |:.::.:.  .|.:.....|.:
Human   127 LEYAPFDDDDGPVDCDCPASCYRGH--RGYRTKH---------WSSSSASP--PPKKKKKKKGGH 178

  Fly   258 KTRRPAVSKRTHPDCACACQQKDPEPALEPAHRTAEHSIQKELPSSQMKINIDGSVLLELLKYSS 322
              ||....:|...:|:|.                                             ||
Human   179 --RRSRKKRRLESECSCG---------------------------------------------SS 196

  Fly   323 SSLLGTLLGAGSAVATSARDTHQIAEAQQQKNARLREAFNISEYFVEGSSFDGDRKAKEDLAKSV 387
            |.|                                                   ||.|:.:.|
Human   197 SPL---------------------------------------------------RKKKKSVKK-- 208

  Fly   388 ALQKELDAQRESLAAAAAAAAAGKDKETGKRYALVRTPSRERDR-DAGDAAANGDERDHVSKTDK 451
                                                   ..||| |:|
Human   209 ---------------------------------------HRRDRSDSG----------------- 217

  Fly   452 KKRKKRARESSASPERKKKKKSKKHKKESKSKKKRSRKRKHSES-GRDSDRDSDEEDDSSEEERR 515
            .:||:|.|..|:..:||:|.|.|              ||.|:|| ||.|.|.|.....|......
Human   218 SRRKRRHRSRSSKCKRKEKNKEK--------------KRPHTESPGRRSHRHSSGSSHSPSLSSH 268

  Fly   516 ESKNVRKKAKKDKKKRDKKLKKKSRARASSSDSERTNSPSRKENKSDRSRGAKASKSDEKAPQQE 580
            .|.: |..::...|.||:..|..|: |:|.|   |:.|||              ..|...:||:
Human   269 YSDS-RSPSRLSPKHRDEGRKTGSQ-RSSGS---RSPSPS--------------GGSGWGSPQR- 313

  Fly   581 NVMRSRSRERKDTRSSRPLEASIDSRQRKP-------RERSAA---TPPRKEPERHRERSKDRQR 635
               ...|.:|......||  .|..|...||       |:::||   |||.:..|....||....:
Human   314 ---NGGSGQRSGAHGGRP--GSAHSPPDKPSSPSPRVRDKAAAAAPTPPARGKESPSPRSAPSSQ 373

  Fly   636 SKEKHRSRDRLRSRERQRSRERQRSRERQRSKERQRSKERQRSIERQRSKERQRSKERQRSRSKD 700
            .:....:....|.|.|:|.|.|.||   ..|..|:|.:.|.|....:.|   .||..|.|| |.|
Human   374 GRGGRAAGGAGRRRRRRRRRRRSRS---SASAPRRRGRRRPRPAPPRGS---SRSLSRARS-SSD 431

  Fly   701 ALRCKEKPQCNEKERSRERRRSKSKDRQRSKEKHRPKDEQQSVDKRRDRSTDRSKENQRS---NE 762
            :...:..|....:..|........|..:....:.||.....|......|.....|.:.||   :.
Human   432 SGSGRGAPGPGPEPGSERGHGGHGKRAKERPPRARPASTSPSPGAHGRRGGPEGKSSSRSPGPHP 496

  Fly   763 RQRSKERQRSKERERSKD-RQRSRERRRSKEGQLSKDRQGLKERQRSNERKRSKERQPSKEKQRS 826
            |..|..|..||.|.||.: |..|..|..|.:..||:|:.|           ..:.|....|..|:
Human   497 RSWSSSRSPSKSRSRSAEKRPHSPSRSPSPKKPLSRDKDG-----------EGRARHSEAEATRA 550

  Fly   827 RERQRSREPLQSKDRQRSKERQRSRERPA--KEARPTRS 863
            |.|.||..|:          |:|.|:.|:  :..|.|||
Human   551 RRRSRSYSPI----------RKRRRDSPSFMEPRRITRS 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Srrm234	NP_001097475.2	cwf21_SRRM2-like	52..100	CDD:410600	25/47 (53%)
		PTZ00121	<560..1154	CDD:173412	83/320 (26%)
		U2AF_lg	747..>876	CDD:273727	36/123 (29%)
		SRRM_C	<1584..1612	CDD:464573
SRRM3	NP_001278760.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..47		9/45 (20%)
		cwf21_SRRM3	34..101	CDD:410602	30/109 (28%)