Protein Alignment CG17249 and PRCC

DIOPT Version :9

• Sequence 1: NP_647638.1
• Gene: CG17249 / 38201
• FlyBaseID: FBgn0035249
• Length: 472
• Species: Drosophila melanogaster
• Sequence 2: NP_005964.3
• Gene: PRCC / 5546
• HGNCID: 9343
• Length: 491
• Species: Homo sapiens
• Alignment Length: 551
• Identity: 137/551 - (24%)
• Similarity: 196/551 - (35%)
• Gaps: 139/551 - (25%)

  Fly     1 MSLVAYAASSDEDSENEEENSVPQVEVIKPQAKP-------STPSEAYLARESTSGHISDEDDDY 58
            |||||| |||||...:|.|....:.|.:.|.:.|       |.|:
Human     1 MSLVAY-ASSDESEPDEAEPEPEEEEAVAPTSGPALGGLFASLPA-------------------- 44

  Fly    59 VPQEVSLQELKPPNGRLLLALPKPKVTAPAKDLENEDVDNQVTSAFANLPMP------RTAAKGK 117
             |:..:|  |.||...|..|.|.|.:..|............:.......|.|      ..|..|:
Human    45 -PKGPAL--LPPPPQMLAPAFPPPLLLPPPTGDPRLQPPPPLPFGLGGFPPPPGVSPAEAAGVGE 106

  Fly   118 AIVEEKDDEFLHKKALPVE----IEKPPP-----PPV--------KGKVKISIPSLRDFSDVDQE 165
            .:          ...||..    :..|||     ||:        |..|||:.|.|.. .|.|.|
Human   107 GL----------GLGLPSPRGPGLNLPPPIGGAGPPLGLPKPKKRKEPVKIAAPELHK-GDSDSE 160

  Fly   166 KADRAKNKVDKPNVPKGSGLLSLLPQAKSERNFSKNSSSAVAYPSASTTLASSLSNNPAQPRAAP 230
            :.:..|.|.......:|:||.:||||.|   |.:...::.:..|.|       .|..|:...
Human   161 EDEPTKKKTILQGSSEGTGLSALLPQPK---NLTVKETNRLLLPHA-------FSRKPSDGS--- 212

  Fly   231 AFVPDTVKQRRAAHNTEGVDGPKAGHKKNPETKDALKSTKSKPISKPTSLVNASDSEDDDEDGTG 295
               |||...|.|:........|..|......:..|:|:.......:.|..:...:.:.|:|....
Human   213 ---PDTKPSRLASKTKTSSLAPVVGTTTTTPSPSAIKAAAKSAALQVTKQITQEEDDSDEEVAPE 274

  Fly   296 DFFSLNSEQKLPEVS---------------------SNEISALVAKRAAKMVEASS--------- 330
            :||||..:.:.|.|.                     :.:..|..|....||...||
Human   275 NFFSLPEKAEPPGVEPYPYPIPTVPEELPPGTEPEPAFQDDAANAPLEFKMAAGSSGAPWMPKPG 339

  Fly   331 ---KYLEEVAEKEAAEAEAARLQEEQSQIAQKRYHEQQ----------------LNAEAMDALVG 376
               .| .:.:....|.|..|..|:..|    ..|:..|                ::.||...|.|
Human   340 DDYSY-NQFSTYGDANAAGAYYQDYYS----GGYYPAQDPALVPPQEIAPDASFIDDEAFKRLQG 399

  Fly   377 KNAKRRRKEAKEMQVIDISGSQVLPDREEWMRSALASSTTFQPTGVLTDEEPVAGTRRKHQITYL 441
            |    |.:..:|:..::|.|...|...::||..:|....|.:.......|:|....|||||||||
Human   400 K----RNRGREEINFVEIKGDDQLSGAQQWMTKSLTEEKTMKSFSKKKGEQPTGQQRRKHQITYL 460

  Fly   442 AHKAKANEAELQAMWSANRQTRRATQSKYGF 472
            .|:||..|.||:..||.|:.:||.||:||||
Human   461 IHQAKERELELKNTWSENKLSRRQTQAKYGF 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17249	NP_647638.1	PRCC	<371..472	CDD:287255	38/100 (38%)
PRCC	NP_005964.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..244		70/293 (24%)
		Mediates interaction with MAD2L2. /evidence=ECO:0000269|PubMed:11717438	1..100		30/122 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	260..313		8/52 (15%)
		PRCC	370..491	CDD:370923	41/124 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	432..454		4/21 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159858
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3903
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	93	1.000	Inparanoid score	I5083
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007347
OrthoInspector	1	1.000	-	-		oto89736
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13621
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3708
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.970