DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13919 and TMEM185A

DIOPT Version :9

Sequence 1:	NP_647637.1	Gene:	CG13919 / 38200	FlyBaseID:	FBgn0035248	Length:	131	Species:	Drosophila melanogaster
Sequence 2:	NP_115897.1	Gene:	TMEM185A / 84548	HGNCID:	17125	Length:	350	Species:	Homo sapiens

Alignment Length:	169	Identity:	40/169 - (23%)
Similarity:	69/169 - (40%)	Gaps:	51/169 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RALFTWF---------IVLVFLILLCLRLDPRTTWNWFVTFTPLWFFDVIIIIYVIIKFIRKW-R 60
            |.||..|         .:|:|.:||.||||....|:::..|.|:|.:.:::|:...:. ...| |
Human     4 RGLFQDFNPSKFLIYACLLLFSVLLALRLDGIIQWSYWAVFAPIWLWKLMVIVGASVG-TGVWAR 67

  Fly    61 N-------LTCLTDLLFLYKWNIAGV---LLTIASQVMICLTLEYPQQ------IPIY----VTV 105
            |       .||:.     :|..:..|   ||.:..:|::|..:|....      :|::    |:|
Human    68 NPQYRAEGETCVE-----FKAMLIAVGIHLLLLMFEVLVCDRIERGSHFWLLVFMPLFFVSPVSV 127

  Fly   106 APVI------------LLLSTAI---FYVGSRLGKREGW 129
            |..:            :|.|..|   .::..||.|...|
Human   128 AACVWGFRHDRSLELEILCSVNILQFIFIALRLDKIIHW 166

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13919	NP_647637.1	None
TMEM185A	NP_115897.1	Tmemb_185A	31..253	CDD:402059	31/142 (22%)
TMEM185A	NP_115897.1	Mediates interaction with MAP1B. /evidence=ECO:0000269\|PubMed:15525354	298..350
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3879
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900