DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment alphaCOP and COPB2

DIOPT Version :9

Sequence 1:NP_477395.1 Gene:alphaCOP / 38199 FlyBaseID:FBgn0025725 Length:1234 Species:Drosophila melanogaster
Sequence 2:NP_004757.1 Gene:COPB2 / 9276 HGNCID:2232 Length:906 Species:Homo sapiens


Alignment Length:973 Identity:245/973 - (25%)
Similarity:412/973 - (42%) Gaps:197/973 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 SKSARVKGLSFHPKRPWILVSLHSGVIQLWDYRMHTLLEKFDEHDGPVRGVAFHQQMPLFVSGGD 71
            ::|.|||.:..||..||:|.||::|.:.:|::...||::.|:..|.|||...|..:....|:|.|
Human    13 ARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKNWVVTGAD 77

  Fly    72 DYKIKVWNYKQRRCIFTLLAHLDYVRTVAFHHEYPWILSASDDQTIRIWNWQSR-NCICVLTGHN 135
            |.:|:|:||.....:....||.||:|.:|.|...|:||::|||..|::|:|..: :|..|..||.
Human    78 DMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHT 142

  Fly   136 HYVMCAQFHPTE-DQIVSASLDQTVRVWDISGLRKKNVAPGPGGLDDHLKGHPGATDLFGQADAV 199
            ||||....:|.: :|..|||||:|::||.:.                  ...|..|         
Human   143 HYVMQIVINPKDNNQFASASLDRTIKVWQLG------------------SSSPNFT--------- 180

  Fly   200 VKHVLEGHDRGVNWASFHP--TLPLIVSGADDRLVKLWRMNEYKAWEVDTCRGHYNNVSSVLFHP 262
                ||||::|||...::.  ..|.::|||||||||:|.......  |.|..||..|||...|||
Human   181 ----LEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTC--VQTLEGHAQNVSCASFHP 239

  Fly   263 RQDLILSNGEDRSIRVWDMTKRQCLFTFRRDNERFWILTAHPTLNLFAAGHDGGMVVFKLERERP 327
            ...:|::..||.::|:|..:..:...|.....||.|.:.:....|..|.|:|.|.::.||.||.|
Human   240 ELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSIIVKLGREEP 304

  Fly   328 AYAV--HGNILY----YVKERFLRKLDFTTTKDTVVMQLR---PGKSPVY--SMSYNPALNAVLI 381
            |.::  :|.|::    .|::..|:.:.....||...:.|.   .|...:|  ::.:||....|::
Human   305 AMSMDANGKIIWAKHSEVQQANLKAMGDAEIKDGERLPLAVKDMGSCEIYPQTIQHNPNGRFVVV 369

  Fly   382 C-------TRTNNLENSTYDLCQIPKDTESQSESDSKRSSGITAIWVARNRFAVLDRNQQLVIKN 439
            |       .....|.|.::...|........||...:.|:.|..|:                 ||
Human   370 CGDGEYIIYTAMALRNKSFGSAQEFAWAHDSSEYAIRESNSIVKIF-----------------KN 417

  Fly   440 FKNEVTKKLPTFCEEIFYAGTGMLLIRDPEFVTLYEVQRLVSVGSIKLAKCRYVVWSPDMSLVAL 504
            ||.:.:.| |.|..|..|.|. :|.:|....:..|:......:..|:: :.:::.||....||.:
Human   418 FKEKKSFK-PDFGAESIYGGF-LLGVRSVNGLAFYDWDNTELIRRIEI-QPKHIFWSDSGELVCI 479

  Fly   505 LCKHSVTICDRRLQYLC--------------------------TVQENCRVKSGAWDESGVFIYT 543
            ..:.|..|    |:||.                          .:||  .||:|.| ....||||
Human   480 ATEESFFI----LKYLSEKVLAAQETHEGVTEDGIEDAFEVLGEIQE--IVKTGLW-VGDCFIYT 537

  Fly   544 TS-NHIKYAITNGDHGIIRTLDLPIYLTRV--KGNQVFCLDRECRTRVLHIDPTEYKFKLALIQR 605
            :| |.:.|.: .|:...|..||..:||...  |.|:::..|:|.......:..:..:::.|:::|
Human   538 SSVNRLNYYV-GGEIVTIAHLDRTMYLLGYIPKDNRLYLGDKELNIISYSLLVSVLEYQTAVMRR 601

  Fly   606 KY---DEVLHMVRNARLVGQSIIAYLQQKGYPEVALHFVKDEKTRFGLALECGNIEIALEAAKAL 667
            .:   |:||..:...:..  .:..:|:::|:.:.||....|.:.||.|||:.|.::||.:.|...
Human   602 DFSMADKVLPTIPKEQRT--RVAHFLEKQGFKQQALTVSTDPEHRFELALQLGELKIAYQLAVEA 664

  Fly   668 DDKDCWDRLGQSALLQGNHQVVEMCYQRTKNFDKLSFLYLITGNLEKLKKMNKIAEIRKDVSAQY 732
            :.:..|.:|.:.|:.:....:.:.|....:::..|..|...:||...:.|:.:.||.....:..:
Human   665 ESEQKWKQLAELAISKCQFGLAQECLHHAQDYGGLLLLATASGNANMVNKLAEGAERDGKNNVAF 729

  Fly   733 QGALLLGDVKERVNILKNCGQLSLAYLTAATHGFDELTESLGESITSQGNSLPEVNPN-AQLLQP 796
            ....|.|.|...:.:|...|:|..|...|.|:    |...:...:.....:|.:||.. |:.|..
Human   730 MSYFLQGKVDACLELLIRTGRLPEAAFLARTY----LPSQVSRVVKLWRENLSKVNQKAAESLAD 790

  Fly   797 PVPIQQL---------------ETN---WP--------------LLSVSKGFFEGAMVTRAGSSA 829
            |...:.|               ||:   ||              ::...|.|        ..|.:
Human   791 PTEYENLFPGLKEAFVVEEWVKETHADLWPAKQYPLVTPNEERNVMEEGKDF--------QPSRS 847

  Fly   830 TARQALN---------------------------INADAALLDEHNGGGDGWGADADLGLDED 865
            ||:|.|:                           ::.|...|::.:        ..|:.||||
Human   848 TAQQELDGKPASPTPVIVASHTANKEEKSLLELEVDLDNLELEDID--------TTDINLDED 902

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alphaCOPNP_477395.1 WD40 <2..320 CDD:225201 107/316 (34%)
WD40 5..321 CDD:238121 107/317 (34%)
WD40 repeat 15..49 CDD:293791 12/33 (36%)
WD40 repeat 57..91 CDD:293791 9/33 (27%)
WD40 repeat 97..133 CDD:293791 14/36 (39%)
WD40 repeat 138..205 CDD:293791 14/67 (21%)
WD40 repeat 212..249 CDD:293791 14/38 (37%)
WD40 repeat 255..291 CDD:293791 11/35 (31%)
WD40 repeat 299..352 CDD:293791 15/58 (26%)
Coatomer_WDAD 354..765 CDD:281977 101/454 (22%)
COPI_C 815..1228 CDD:284395 13/78 (17%)
COPB2NP_004757.1 WD40 8..297 CDD:238121 107/316 (34%)
WD 1 13..52 15/38 (39%)
WD40 repeat 19..55 CDD:293791 13/35 (37%)
WD40 24..428 CDD:225201 136/454 (30%)
WD 2 55..94 13/38 (34%)
WD 3 97..136 17/38 (45%)
WD40 repeat 103..140 CDD:293791 14/36 (39%)
WD 4 140..180 17/57 (30%)
WD40 repeat 145..182 CDD:293791 14/67 (21%)
WD 5 183..224 17/42 (40%)
WD40 repeat 189..226 CDD:293791 14/38 (37%)
WD 6 227..266 13/38 (34%)
WD40 repeat 232..268 CDD:293791 11/35 (31%)
Coatomer_WDAD 320..763 CDD:281977 104/476 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 837..870 7/40 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D122926at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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