DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alphaCOP and COP1

DIOPT Version :9

Sequence 1:	NP_477395.1	Gene:	alphaCOP / 38199	FlyBaseID:	FBgn0025725	Length:	1234	Species:	Drosophila melanogaster
Sequence 2:	NP_010136.1	Gene:	COP1 / 851410	SGDID:	S000002304	Length:	1201	Species:	Saccharomyces cerevisiae

Alignment Length:	1266	Identity:	537/1266 - (42%)
Similarity:	747/1266 - (59%)	Gaps:	107/1266 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLTNFESKSARVKGLSFHPKRPWILVSLHSGVIQLWDYRMHTLLEKFDEHDGPVRGVAFHQQMPL 65
            |||.|||||.|.||::|||.|||:||:|.|..||||||||.|||.:|::|:|||||:.||...|:
Yeast     3 MLTKFESKSTRAKGIAFHPSRPWVLVALFSSTIQLWDYRMGTLLHRFEDHEGPVRGLDFHPTQPI 67

  Fly    66 FVSGGDDYKIKVWNYKQRRCIFTLLAHLDYVRTVAFHHEYPWILSASDDQTIRIWNWQSRNCICV 130
            |||.||||.||||:....:|::||..||||||||.||.|.|||:||||||||||||||:|..|..
Yeast    68 FVSAGDDYTIKVWSLDTNKCLYTLTGHLDYVRTVFFHRELPWIISASDDQTIRIWNWQNRKEIAC 132

  Fly   131 LTGHNHYVMCAQFHPTEDQIVSASLDQTVRVWDISGLRKKNVAPGPGGLDDHLKGHPGATDLFGQ 195
            ||||||:|||||||||:|.|||||||:|:|:||||||||::.|||....::.:.......|  |.
Yeast   133 LTGHNHFVMCAQFHPTDDLIVSASLDETIRIWDISGLRKRHSAPGTSSFEEQMSAQQNLLD--GS 195

  Fly   196 -ADAVVKHVLEGHDRGVNWASFHPTLPLIVSGADDRLVKLWRMNEYKAWEVDTCRGHYNNVSSVL 259
             .|.|||.:||||.||||||||||||||||||:|||.||||||:..|||||||||||.|||.||:
Yeast   196 LGDCVVKFILEGHTRGVNWASFHPTLPLIVSGSDDRQVKLWRMSATKAWEVDTCRGHTNNVDSVI 260

  Fly   260 FHPRQDLILSNGEDRSIRVWDMTKRQCLFTFRRDNERFWILTAHPTLNLFAAGHDGGMVVFKLER 324
            |||.|:||:|.|||:::||||:.||..:..|:|:|:|||::.|||.:|||.|.||.|::||||:|
Yeast   261 FHPHQNLIISVGEDKTLRVWDLDKRTPVKQFKRENDRFWLIAAHPHINLFGAAHDSGIMVFKLDR 325

  Fly   325 ERPAYAVHGNILYYVK-ERFLRKLDFTTTKDTVVMQLRPGKSPVYSM-------------SYNPA 375
            |||...:|.|.|::|. |:.::..:|         |.|....|..|:             ||||:
Yeast   326 ERPCSFIHQNQLFFVNAEKQIQSFNF---------QKRVASLPYASLKGIGQPWDAFRSISYNPS 381

  Fly   376 LNAVLICTRTNNLENSTYDLCQIPKDTESQSESDS-KRSSGITAIWVARNRFAVLDRNQQLV-IK 438
            .::||:     |..|..:.|..:||......|..| .:.:|..|.:|.||||.|.::|.:.| ::
Yeast   382 QHSVLV-----NEANGKFALVILPKQPVGAVEPTSVTQDTGNFATFVGRNRFVVYNKNTESVEVR 441

  Fly   439 NFKNEVTK--KLPTFCEEIFYAGTGMLLIRDPEFVTLYEVQRLVSVGSIKLAKCRYVVWSPDMSL 501
            :.:|:||:  |:......|..||.|.:|:..|..|.||:||:...|..:.:...:||.||.|...
Yeast   442 SLENKVTRNIKVEETVRTIVAAGPGSVLVIHPREVILYDVQQGKKVSQLAVKNVKYVSWSLDGQY 506

  Fly   502 VALLCKHSVTICDRRLQYLCTVQENCRVKSGAWDESGVFIYTTSNHIKYAITNGDHGIIRTLDLP 566
            |||:.||::|:..::|:.:.::.|..|:||.||||:||.||:|.|||:|::.|||.|||:||:..
Yeast   507 VALMSKHTITLATKKLELINSMHETIRIKSAAWDETGVLIYSTLNHIRYSLLNGDRGIIKTLEKT 571

  Fly   567 IYLTRVKGNQVFCLDRECRTRVLHIDPTEYKFKLALIQRKYDEVLHMVRNARLVGQSIIAYLQQK 631
            :|:|:|:|..|:||:||....:|.||||||:||.||:.:.:.|||.:::::.||||:||:|||:.
Yeast   572 LYITKVQGKLVYCLNREGEIEILTIDPTEYRFKKALVNKNFPEVLRLIKDSNLVGQNIISYLQKS 636

  Fly   632 GYPEVALHFVKDEKTRFGLALECGNIEIALEAAKALDDKDCWDRLGQSALLQGNHQVVEMCYQRT 696
            ||||:||.||:|...||.||||.||:::||:.||.|:|...|:||.|.||.|||..:.||.||..
Yeast   637 GYPEIALQFVQDPHIRFDLALEYGNLDVALDEAKKLNDSSTWERLIQEALAQGNASLAEMIYQTQ 701

  Fly   697 KNFDKLSFLYLITGNLEKLKKMNKIAEIRKDVSAQYQGALLLGDVKERVNILKNCGQLSLAYLTA 761
            .:|||||||||:||::.||.||..||:.|:|..:...........|||.:|....|.|.|||..|
Yeast   702 HSFDKLSFLYLVTGDVNKLSKMQNIAQTREDFGSMLLNTFYNNSTKERSSIFAEGGSLPLAYAVA 766

  Fly   762 ATHGFDELTESLGE--SITSQGNSLPEVNPNAQLLQPPVPIQQLETNWPLLSVSKGFFEGAMVTR 824
            ..:|.:....:..|  .:..|..:||:....:..:|.||..:.|| .|||......:||.|::
Yeast   767 KANGDEAAASAFLEQAEVDEQDVTLPDQMDASNFVQRPVISKPLE-KWPLKEAELSYFEKAVL-- 828

  Fly   825 AGSSATARQALNINADAALLDEHNGGGDGWGADADLGLDED-----GDDEMHDAL--SNDGDGGA 882
                                          |...||.:|::     ...|..:.|  .|..|...
Yeast   829 ------------------------------GQIDDLTIDDETPAVNTTQEQEEPLGEENFNDEDI 863

  Fly   883 GGEEGAGWDVGDDDLVVPEELASKIKASALDSNYYAAPNKGLSPAQQ-----WANNSPLVLDHVK 942
            |.:||| ||:||:||.|.|||..:::...:           .||||:     |..||.|....|.
Yeast   864 GEDEGA-WDLGDEDLDVGEELPEEVEQGEI-----------TSPAQEVETAIWIKNSKLPAVLVA 916

  Fly   943 AGSFETAFRLLHDQLGVVNFQPFKTLFLQNYACSRTSYTANP-NLQSLSGYPLRNY----SETNI 1002
            ||:|:.|.:.|..|:|||..:|.|..|...|...||...:.| .|.:..|| :|.|    ||..|
Yeast   917 AGAFDAAVQALSKQVGVVKLEPLKKYFTNIYEGCRTYIPSTPCELPAQLGY-VRAYDDTVSEDQI 980

  Fly  1003 KLQRPAVGIKLNDLVARLQAGYQLTTSGKFSEAVEKFHSILISIPLLVVDTKLDAAEAQQLLRIC 1067
            ....|.:.: :|:   ::..||:.....|...|:|.|...:..|.||:||...|...|.::|...
Yeast   981 LPYVPGLDV-VNE---KMNEGYKNFKLNKPDIAIECFREAIYRITLLMVDDAEDEKLAHKILETA 1041

  Fly  1068 AEYIVGLKMETVRKGMPKSTLEEQKRLCEMAAYFTHCKLQPVHQILTLRTALNMFFKLKNYKTAA 1132
            .|||:||.:|..|:.:.:.   ...|:.|:|||||..||.|:|:...|:.|::..||.||:..|:
Yeast  1042 REYILGLSIELERRSLKEG---NTVRMLELAAYFTKAKLSPIHRTNALQVAMSQHFKHKNFLQAS 1103

  Fly  1133 SFARRLLELAPRPDVAQQVRKILQACEVNPVDEHQLQYEEFNPFTICGISWKPLYRGKPEVTCPF 1197
            .||...|::......|:|.|||....:....|...:.::.:..|.||..::||:|...|.|:.|.
Yeast  1104 YFAGEFLKIISSGPRAEQARKIKNKADSMASDAIPIDFDPYAKFDICAATYKPIYEDTPSVSDPL 1168

  Fly  1198 CSSSFDPQFKGNLCTVCEVSQIGKDSIGLRI 1228
            ..|.:....|..:..:..:|:||..:.||||
Yeast  1169 TGSKYVITEKDKIDRIAMISKIGAPASGLRI 1199

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaCOP	NP_477395.1	WD40	<2..320	CDD:225201	206/318 (65%)
		WD40	5..321	CDD:238121	205/316 (65%)
		WD40 repeat	15..49	CDD:293791	22/33 (67%)
		WD40 repeat	57..91	CDD:293791	17/33 (52%)
		WD40 repeat	97..133	CDD:293791	26/35 (74%)
		WD40 repeat	138..205	CDD:293791	36/67 (54%)
		WD40 repeat	212..249	CDD:293791	31/36 (86%)
		WD40 repeat	255..291	CDD:293791	19/35 (54%)
		WD40 repeat	299..352	CDD:293791	24/53 (45%)
		Coatomer_WDAD	354..765	CDD:281977	177/427 (41%)
		COPI_C	815..1228	CDD:284395	124/429 (29%)
COP1	NP_010136.1	WD40	17..322	CDD:238121	197/306 (64%)
		WD40 repeat	17..51	CDD:293791	22/33 (67%)
		WD40 repeat	59..93	CDD:293791	17/33 (52%)
		WD40 repeat	99..135	CDD:293791	26/35 (74%)
		WD40 repeat	140..206	CDD:293791	36/67 (54%)
		WD40 repeat	213..250	CDD:293791	31/36 (86%)
		WD40 repeat	256..292	CDD:293791	19/35 (54%)
		Coatomer_WDAD	343..770	CDD:397941	179/440 (41%)
		COPI_C	829..1199	CDD:399736	121/389 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346562
Domainoid	1	1.000	336	1.000	Domainoid score	I167
eggNOG	1	0.900	-	-		E1_KOG0292
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3218
Inparanoid	1	1.050	968	1.000	Inparanoid score	I33
Isobase	1	0.950	-	0	Normalized mean entropy	S497
OMA	1	1.010	-	-		QHG53722
OrthoFinder	1	1.000	-	-		FOG0004006
OrthoInspector	1	1.000	-	-		oto99876
orthoMCL	1	0.900	-	-		OOG6_101600
Panther	1	1.100	-	-	LDO	PTHR19876
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R225
SonicParanoid	1	1.000	-	-		X2767
TreeFam	1	0.960	-	-
	16	15.740