DRSC/TRiP Functional Genomics Resources

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Protein Alignment alphaCOP and COP1

DIOPT Version :10

Sequence 1:NP_477395.1 Gene:alphaCOP / 38199 FlyBaseID:FBgn0025725 Length:1234 Species:Drosophila melanogaster
Sequence 2:NP_010136.1 Gene:COP1 / 851410 SGDID:S000002304 Length:1201 Species:Saccharomyces cerevisiae


Alignment Length:1266 Identity:537/1266 - (42%)
Similarity:747/1266 - (59%) Gaps:107/1266 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MLTNFESKSARVKGLSFHPKRPWILVSLHSGVIQLWDYRMHTLLEKFDEHDGPVRGVAFHQQMPL 65
            |||.|||||.|.||::|||.|||:||:|.|..||||||||.|||.:|::|:|||||:.||...|:
Yeast     3 MLTKFESKSTRAKGIAFHPSRPWVLVALFSSTIQLWDYRMGTLLHRFEDHEGPVRGLDFHPTQPI 67

  Fly    66 FVSGGDDYKIKVWNYKQRRCIFTLLAHLDYVRTVAFHHEYPWILSASDDQTIRIWNWQSRNCICV 130
            |||.||||.||||:....:|::||..||||||||.||.|.|||:||||||||||||||:|..|..
Yeast    68 FVSAGDDYTIKVWSLDTNKCLYTLTGHLDYVRTVFFHRELPWIISASDDQTIRIWNWQNRKEIAC 132

  Fly   131 LTGHNHYVMCAQFHPTEDQIVSASLDQTVRVWDISGLRKKNVAPGPGGLDDHLKGHPGATDLFGQ 195
            ||||||:|||||||||:|.|||||||:|:|:||||||||::.|||....::.:.......|  |.
Yeast   133 LTGHNHFVMCAQFHPTDDLIVSASLDETIRIWDISGLRKRHSAPGTSSFEEQMSAQQNLLD--GS 195

  Fly   196 -ADAVVKHVLEGHDRGVNWASFHPTLPLIVSGADDRLVKLWRMNEYKAWEVDTCRGHYNNVSSVL 259
             .|.|||.:||||.||||||||||||||||||:|||.||||||:..|||||||||||.|||.||:
Yeast   196 LGDCVVKFILEGHTRGVNWASFHPTLPLIVSGSDDRQVKLWRMSATKAWEVDTCRGHTNNVDSVI 260

  Fly   260 FHPRQDLILSNGEDRSIRVWDMTKRQCLFTFRRDNERFWILTAHPTLNLFAAGHDGGMVVFKLER 324
            |||.|:||:|.|||:::||||:.||..:..|:|:|:|||::.|||.:|||.|.||.|::||||:|
Yeast   261 FHPHQNLIISVGEDKTLRVWDLDKRTPVKQFKRENDRFWLIAAHPHINLFGAAHDSGIMVFKLDR 325

  Fly   325 ERPAYAVHGNILYYVK-ERFLRKLDFTTTKDTVVMQLRPGKSPVYSM-------------SYNPA 375
            |||...:|.|.|::|. |:.::..:|         |.|....|..|:             ||||:
Yeast   326 ERPCSFIHQNQLFFVNAEKQIQSFNF---------QKRVASLPYASLKGIGQPWDAFRSISYNPS 381

  Fly   376 LNAVLICTRTNNLENSTYDLCQIPKDTESQSESDS-KRSSGITAIWVARNRFAVLDRNQQLV-IK 438
            .::||:     |..|..:.|..:||......|..| .:.:|..|.:|.||||.|.::|.:.| ::
Yeast   382 QHSVLV-----NEANGKFALVILPKQPVGAVEPTSVTQDTGNFATFVGRNRFVVYNKNTESVEVR 441

  Fly   439 NFKNEVTK--KLPTFCEEIFYAGTGMLLIRDPEFVTLYEVQRLVSVGSIKLAKCRYVVWSPDMSL 501
            :.:|:||:  |:......|..||.|.:|:..|..|.||:||:...|..:.:...:||.||.|...
Yeast   442 SLENKVTRNIKVEETVRTIVAAGPGSVLVIHPREVILYDVQQGKKVSQLAVKNVKYVSWSLDGQY 506

  Fly   502 VALLCKHSVTICDRRLQYLCTVQENCRVKSGAWDESGVFIYTTSNHIKYAITNGDHGIIRTLDLP 566
            |||:.||::|:..::|:.:.::.|..|:||.||||:||.||:|.|||:|::.|||.|||:||:..
Yeast   507 VALMSKHTITLATKKLELINSMHETIRIKSAAWDETGVLIYSTLNHIRYSLLNGDRGIIKTLEKT 571

  Fly   567 IYLTRVKGNQVFCLDRECRTRVLHIDPTEYKFKLALIQRKYDEVLHMVRNARLVGQSIIAYLQQK 631
            :|:|:|:|..|:||:||....:|.||||||:||.||:.:.:.|||.:::::.||||:||:|||:.
Yeast   572 LYITKVQGKLVYCLNREGEIEILTIDPTEYRFKKALVNKNFPEVLRLIKDSNLVGQNIISYLQKS 636

  Fly   632 GYPEVALHFVKDEKTRFGLALECGNIEIALEAAKALDDKDCWDRLGQSALLQGNHQVVEMCYQRT 696
            ||||:||.||:|...||.||||.||:::||:.||.|:|...|:||.|.||.|||..:.||.||..
Yeast   637 GYPEIALQFVQDPHIRFDLALEYGNLDVALDEAKKLNDSSTWERLIQEALAQGNASLAEMIYQTQ 701

  Fly   697 KNFDKLSFLYLITGNLEKLKKMNKIAEIRKDVSAQYQGALLLGDVKERVNILKNCGQLSLAYLTA 761
            .:|||||||||:||::.||.||..||:.|:|..:...........|||.:|....|.|.|||..|
Yeast   702 HSFDKLSFLYLVTGDVNKLSKMQNIAQTREDFGSMLLNTFYNNSTKERSSIFAEGGSLPLAYAVA 766

  Fly   762 ATHGFDELTESLGE--SITSQGNSLPEVNPNAQLLQPPVPIQQLETNWPLLSVSKGFFEGAMVTR 824
            ..:|.:....:..|  .:..|..:||:....:..:|.||..:.|| .|||......:||.|::  
Yeast   767 KANGDEAAASAFLEQAEVDEQDVTLPDQMDASNFVQRPVISKPLE-KWPLKEAELSYFEKAVL-- 828

  Fly   825 AGSSATARQALNINADAALLDEHNGGGDGWGADADLGLDED-----GDDEMHDAL--SNDGDGGA 882
                                          |...||.:|::     ...|..:.|  .|..|...
Yeast   829 ------------------------------GQIDDLTIDDETPAVNTTQEQEEPLGEENFNDEDI 863

  Fly   883 GGEEGAGWDVGDDDLVVPEELASKIKASALDSNYYAAPNKGLSPAQQ-----WANNSPLVLDHVK 942
            |.:||| ||:||:||.|.|||..:::...:           .||||:     |..||.|....|.
Yeast   864 GEDEGA-WDLGDEDLDVGEELPEEVEQGEI-----------TSPAQEVETAIWIKNSKLPAVLVA 916

  Fly   943 AGSFETAFRLLHDQLGVVNFQPFKTLFLQNYACSRTSYTANP-NLQSLSGYPLRNY----SETNI 1002
            ||:|:.|.:.|..|:|||..:|.|..|...|...||...:.| .|.:..|| :|.|    ||..|
Yeast   917 AGAFDAAVQALSKQVGVVKLEPLKKYFTNIYEGCRTYIPSTPCELPAQLGY-VRAYDDTVSEDQI 980

  Fly  1003 KLQRPAVGIKLNDLVARLQAGYQLTTSGKFSEAVEKFHSILISIPLLVVDTKLDAAEAQQLLRIC 1067
            ....|.:.: :|:   ::..||:.....|...|:|.|...:..|.||:||...|...|.::|...
Yeast   981 LPYVPGLDV-VNE---KMNEGYKNFKLNKPDIAIECFREAIYRITLLMVDDAEDEKLAHKILETA 1041

  Fly  1068 AEYIVGLKMETVRKGMPKSTLEEQKRLCEMAAYFTHCKLQPVHQILTLRTALNMFFKLKNYKTAA 1132
            .|||:||.:|..|:.:.:.   ...|:.|:|||||..||.|:|:...|:.|::..||.||:..|:
Yeast  1042 REYILGLSIELERRSLKEG---NTVRMLELAAYFTKAKLSPIHRTNALQVAMSQHFKHKNFLQAS 1103

  Fly  1133 SFARRLLELAPRPDVAQQVRKILQACEVNPVDEHQLQYEEFNPFTICGISWKPLYRGKPEVTCPF 1197
            .||...|::......|:|.|||....:....|...:.::.:..|.||..::||:|...|.|:.|.
Yeast  1104 YFAGEFLKIISSGPRAEQARKIKNKADSMASDAIPIDFDPYAKFDICAATYKPIYEDTPSVSDPL 1168

  Fly  1198 CSSSFDPQFKGNLCTVCEVSQIGKDSIGLRI 1228
            ..|.:....|..:..:..:|:||..:.||||
Yeast  1169 TGSKYVITEKDKIDRIAMISKIGAPASGLRI 1199

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alphaCOPNP_477395.1 WD40 5..321 CDD:238121 205/316 (65%)
WD40 repeat 15..49 CDD:293791 22/33 (67%)
WD40 repeat 57..91 CDD:293791 17/33 (52%)
WD40 repeat 97..133 CDD:293791 26/35 (74%)
WD40 repeat 138..205 CDD:293791 36/67 (54%)
WD40 repeat 212..249 CDD:293791 31/36 (86%)
WD40 repeat 255..291 CDD:293791 19/35 (54%)
WD40 repeat 299..352 CDD:293791 24/53 (45%)
Coatomer_WDAD_alpha 327..773 CDD:438573 185/463 (40%)
WD40 repeat 327..340 CDD:438573 4/12 (33%)
WD40 repeat 365..414 CDD:438573 15/62 (24%)
WD40 repeat 417..439 CDD:438573 9/22 (41%)
WD40 repeat 458..487 CDD:438573 11/28 (39%)
WD40 repeat 490..522 CDD:438573 12/31 (39%)
WD40 repeat 538..564 CDD:438573 16/25 (64%)
WD40 repeat 566..591 CDD:438573 10/24 (42%)
COPI_C 815..1228 CDD:462050 124/429 (29%)
COP1NP_010136.1 WD40 17..322 CDD:238121 197/306 (64%)
WD40 repeat 17..51 CDD:293791 22/33 (67%)
WD40 repeat 59..93 CDD:293791 17/33 (52%)
WD40 repeat 99..135 CDD:293791 26/35 (74%)
WD40 repeat 140..206 CDD:293791 36/67 (54%)
WD40 repeat 213..250 CDD:293791 31/36 (86%)
WD40 repeat 256..292 CDD:293791 19/35 (54%)
Coatomer_WDAD_alpha 328..777 CDD:438573 185/462 (40%)
WD40 repeat 328..341 CDD:438573 4/12 (33%)
WD40 repeat 371..416 CDD:438573 13/49 (27%)
WD40 repeat 419..442 CDD:438573 9/22 (41%)
WD40 repeat 463..492 CDD:438573 11/28 (39%)
WD40 repeat 495..527 CDD:438573 12/31 (39%)
WD40 repeat 543..569 CDD:438573 16/25 (64%)
WD40 repeat 571..596 CDD:438573 10/24 (42%)
COPI_C 829..1199 CDD:462050 121/389 (31%)

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