DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alphaCOP and AT1G62020

DIOPT Version :9

Sequence 1:	NP_477395.1	Gene:	alphaCOP / 38199	FlyBaseID:	FBgn0025725	Length:	1234	Species:	Drosophila melanogaster
Sequence 2:	NP_176393.1	Gene:	AT1G62020 / 842497	AraportID:	AT1G62020	Length:	1216	Species:	Arabidopsis thaliana

Alignment Length:	1257	Identity:	677/1257 - (53%)
Similarity:	894/1257 - (71%)	Gaps:	64/1257 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLTNFESKSARVKGLSFHPKRPWILVSLHSGVIQLWDYRMHTLLEKFDEHDGPVRGVAFHQQMPL 65
            |||.||:||.|||||||||||||||.||||||||||||||.||:::||||:||||||.||...||
plant     1 MLTKFETKSNRVKGLSFHPKRPWILASLHSGVIQLWDYRMGTLIDRFDEHEGPVRGVHFHNSQPL 65

  Fly    66 FVSGGDDYKIKVWNYKQRRCIFTLLAHLDYVRTVAFHHEYPWILSASDDQTIRIWNWQSRNCICV 130
            ||||||||||||||||..||:||||.||||:|||.||||||||:||||||||||||||||.|:.|
plant    66 FVSGGDDYKIKVWNYKNHRCLFTLLGHLDYIRTVQFHHEYPWIVSASDDQTIRIWNWQSRTCVSV 130

  Fly   131 LTGHNHYVMCAQFHPTEDQIVSASLDQTVRVWDISGLRKKNVAPGPGGLDDHLKGHPGATDLFGQ 195
            |||||||||||.|||.||.:||||||||||||||..||||.|:|.    ||.::.....:||||.
plant   131 LTGHNHYVMCASFHPKEDLVVSASLDQTVRVWDIGALRKKTVSPA----DDIMRLTQMNSDLFGG 191

  Fly   196 ADAVVKHVLEGHDRGVNWASFHPTLPLIVSGADDRLVKLWRMNEYKAWEVDTCRGHYNNVSSVLF 260
            .||:||:||||||||||||:|||||||||||||||.||||||||.|||||||.|||.||||||:|
plant   192 VDAIVKYVLEGHDRGVNWAAFHPTLPLIVSGADDRQVKLWRMNETKAWEVDTLRGHMNNVSSVMF 256

  Fly   261 HPRQDLILSNGEDRSIRVWDMTKRQCLFTFRRDNERFWILTAHPTLNLFAAGHDGGMVVFKLERE 325
            |.:||:|:||.||:||||||.|||..|.||||:::|||||..||.:||.|||||.||:|||||||
plant   257 HAKQDIIVSNSEDKSIRVWDATKRTGLQTFRREHDRFWILAVHPEMNLLAAGHDSGMIVFKLERE 321

  Fly   326 RPAYAVHGNILYYVKERFLRKLDFTTTKDTVVMQL-RPG-----KSPVYSMSYNPALNAVLICTR 384
            |||:|:.|:.|:|.|:||||..:::|.:|:.|:.: |||     :|| .::||:|..||||||
plant   322 RPAFALSGDSLFYAKDRFLRYYEYSTQRDSQVIPIRRPGTPSLNQSP-RTLSYSPTENAVLIC-- 383

  Fly   385 TNNLENSTYDLCQIPKDTESQSE--SDSKRSSGITAIWVARNRFAVLDRN-QQLVIKNFKNEVTK 446
             ::|:..:|:|..||||:..:|:  .|:||.:|.:|:::||||||||::: .|:::||.||||.|
plant   384 -SDLDGGSYELYIIPKDSVGRSDVVQDAKRGTGGSAVFIARNRFAVLEKSTSQVLVKNLKNEVVK 447

  Fly   447 K--LPTFCEEIFYAGTGMLLIRDPEFVTLYEVQRLVSVGSIKLAKCRYVVWSPDMSLVALLCKHS 509
            |  ||...:.|||||||.||.|..:.|.::::|:.:.:|.::....||||||.||..||||.||:
plant   448 KSPLPIPTDAIFYAGTGNLLCRSEDKVVIFDLQQRLVLGELQTPFVRYVVWSSDMESVALLSKHT 512

  Fly   510 VTICDRRLQYLCTVQENCRVKSGAWDESGVFIYTTSNHIKYAITNGDHGIIRTLDLPIYLTRVKG 574
            :.|..::|...||:.|..||||||||::|||||||.|||||.:.|||.|||||||:|||:|:|.|
plant   513 IIIASKKLVLQCTLHETIRVKSGAWDDNGVFIYTTLNHIKYCLPNGDSGIIRTLDVPIYITKVSG 577

  Fly   575 NQVFCLDRECRTRVLHIDPTEYKFKLALIQRKYDEVLHMVRNARLVGQSIIAYLQQKGYPEVALH 639
            |.:|||||:.:.:.:.|:.|||.|||:|::::||.|:.|::|::|.||::||||||||:||||||
plant   578 NTIFCLDRDGKNKAITINATEYIFKLSLLRKRYDHVMSMIKNSQLCGQAMIAYLQQKGFPEVALH 642

  Fly   640 FVKDEKTRFGLALECGNIEIALEAAKALDDKDCWDRLGQSALLQGNHQVVEMCYQRTKNFDKLSF 704
            ||:||:.||.||||.|||.:|:.:|..:::||.|.|||..||.|||..:||..||:||||::|||
plant   643 FVEDERIRFNLALESGNISVAVASATQINEKDHWYRLGVEALRQGNSGIVEFAYQQTKNFERLSF 707

  Fly   705 LYLITGNLEKLKKMNKIAEIRKDVSAQYQGALLLGDVKERVNILKNCGQLSLAYLTAATHGFDEL 769
            ||||||||:||.|:.||||::.:|..|:..||.||||||||.||:|.|.|.|||:||:.||.:::
plant   708 LYLITGNLDKLSKLMKIAEVKNNVMGQFHNALYLGDVKERVKILENAGHLPLAYITASVHGLNDI 772

  Fly   770 TESLGESITSQGNSLPEVNPNAQLLQPPVPIQQLETNWPLLSVSKGFFEGAM--VTRAGSSATAR 832
            .|.|...:.....|||| .....||.||.|| ....:||||.|.||.|||.:  ..|.|:
plant   773 AERLATELGDNVPSLPE-GKTPSLLMPPTPI-MCGGDWPLLRVMKGIFEGGLESADRGGT----- 830

  Fly   833 QALNINADAALLDEHNGGGDGWGADADLGLDEDGDDEMHDALSNDGDGGAGGEEGAGWDVGDDDL 897
                       :||.:..|| ||.:.|:.:|...:.::.|.|:....|....:|..||  |.:||
plant   831 -----------VDEEDVEGD-WGEELDINVDGMENRDIEDILAAAEAGEEENDEEGGW--GLEDL 881

  Fly   898 VVPEELASKIKASA-LDSNYYAAPNKGLSPAQQWANNSPLVLDHVKAGSFETAFRLLHDQLGVVN 961
            |:|.||.:. |||| ..|:.:..|.:|:..:|.|:..|.|..:...||||:||.||||.|||:.|
plant   882 VLPPELDTP-KASANARSSVFVTPPQGMPVSQSWSQKSSLAAEQAAAGSFDTAMRLLHRQLGIKN 945

  Fly   962 FQPFKTLFLQNYACSRTSYTANPNLQSLSGYPL------RNYSET---NIKLQRPAVGIKLNDLV 1017
            |.|.|::||..:..|. ||     |::.|..|:      |.:||:   |:: ..||:....:.|.
plant   946 FTPLKSMFLDLFNGSH-SY-----LRAFSSCPVVPLAIERGWSESSSPNVR-SPPALVYDFSQLD 1003

  Fly  1018 ARLQAGYQLTTSGKFSEAVEKFHSILISIPLLVVDTKLDAAEAQQLLRICAEYIVGLKMETVRKG 1082
            .:|::||:.||:|||:||:..|.|||.:|||:||:|:.:..|.::|:.|..||::||:||..|:.
plant  1004 EKLKSGYKATTTGKFTEALRLFLSILHTIPLVVVETRREVDEVKELIVIVKEYVLGLQMELKRRE 1068

  Fly  1083 MPKSTLEEQKRLCEMAAYFTHCKLQPVHQILTLRTALNMFFKLKNYKTAASFARRLLELAPRPDV 1147
            |....:.:|    |:|||||||.||..|..|.|.:|:.:.:|.||..||::|||||||.:|....
plant  1069 MKDDPVRQQ----ELAAYFTHCNLQTPHLRLALLSAMGVCYKAKNLATASNFARRLLETSPVDSQ 1129

  Fly  1148 AQQVRKILQACEVNPVDEHQLQYEEFNPFTICGISWKPLYRGKPEVTCPFCSSSFDPQFKGNLCT 1212
            |:..|:::||.|.|..||.:|.|:..|||.:||.::.|:|||:.:|:||:|::.|.|..:||:||
plant  1130 AKMARQVVQAAERNMTDETKLNYDFRNPFVVCGSTYVPIYRGQKDVSCPYCTARFVPNQEGNICT 1194

  Fly  1213 VCEVSQIGKDSIGLRISNLQFR 1234
            ||:::.||.|:.||..|..|.|
plant  1195 VCDLAVIGADASGLLCSPSQVR 1216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaCOP	NP_477395.1	WD40	<2..320	CDD:225201	242/317 (76%)
		WD40	5..321	CDD:238121	241/315 (77%)
		WD40 repeat	15..49	CDD:293791	28/33 (85%)
		WD40 repeat	57..91	CDD:293791	26/33 (79%)
		WD40 repeat	97..133	CDD:293791	30/35 (86%)
		WD40 repeat	138..205	CDD:293791	40/66 (61%)
		WD40 repeat	212..249	CDD:293791	33/36 (92%)
		WD40 repeat	255..291	CDD:293791	24/35 (69%)
		WD40 repeat	299..352	CDD:293791	32/52 (62%)
		Coatomer_WDAD	354..765	CDD:281977	226/421 (54%)
		COPI_C	815..1228	CDD:284395	165/424 (39%)
AT1G62020	NP_176393.1	WD40	9..317	CDD:238121	238/311 (77%)
		WD40 repeat	15..49	CDD:293791	28/33 (85%)
		WD40 repeat	55..91	CDD:293791	28/35 (80%)
		WD40 repeat	96..132	CDD:293791	29/35 (83%)
		WD40 repeat	139..201	CDD:293791	39/65 (60%)
		WD40 repeat	207..245	CDD:293791	34/37 (92%)
		WD40 repeat	251..288	CDD:293791	25/36 (69%)
		Coatomer_WDAD	337..769	CDD:367786	232/435 (53%)
		COPI_C	816..1210	CDD:369149	165/424 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	444	1.000	Domainoid score	I99
eggNOG	1	0.900	-	-		E1_KOG0292
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3218
Inparanoid	1	1.050	1279	1.000	Inparanoid score	I16
OMA	1	1.010	-	-		QHG53722
OrthoDB	1	1.010	-	-		D139008at2759
OrthoFinder	1	1.000	-	-		FOG0004006
OrthoInspector	1	1.000	-	-		otm3210
orthoMCL	1	0.900	-	-		OOG6_101600
Panther	1	1.100	-	-	LDO	PTHR19876
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2767
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840