DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alphaCOP and AT3G15980

DIOPT Version :9

Sequence 1:	NP_477395.1	Gene:	alphaCOP / 38199	FlyBaseID:	FBgn0025725	Length:	1234	Species:	Drosophila melanogaster
Sequence 2:	NP_001189908.1	Gene:	AT3G15980 / 820842	AraportID:	AT3G15980	Length:	930	Species:	Arabidopsis thaliana

Alignment Length:	998	Identity:	260/998 - (26%)
Similarity:	429/998 - (42%)	Gaps:	200/998 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FESKSARVKGLSFHPKRPWILVSLHSGVIQLWDYRMHTLLEKFDEHDGPVRGVAFHQQMPLFVSG 69
            |..:|.|||.:..||..||||.||:||.:.:|:|:..|:.:.|:..:.|||...|..:....|:|
plant    11 FAQRSERVKSVDLHPTEPWILASLYSGTVCIWNYQTQTITKSFEVTELPVRSAKFIPRKQWVVAG 75

  Fly    70 GDDYKIKVWNYKQRRCIFTLLAHLDYVRTVAFHHEYPWILSASDDQTIRIWNWQSR-NCICVLTG 133
            .||..|:|:||.....:....||.||:|.||.|...|::||:|||..|::|:|::. .|..:..|
plant    76 ADDMYIRVYNYNTMDKVKVFEAHSDYIRCVAVHPTLPYVLSSSDDMLIKLWDWENGWACTQIFEG 140

  Fly   134 HNHYVMCAQFHPTE-DQIVSASLDQTVRVWDISGLRKKNVAPGPGGLDDHLKGHPGATDLFGQAD 197
            |:||||...|:|.: :...|||||:|:::|::.       :|.|
plant   141 HSHYVMQVVFNPKDTNTFASASLDRTIKIWNLG-------SPDP--------------------- 177

  Fly   198 AVVKHVLEGHDRGVNWASFHP--TLPLIVSGADDRLVKLWRMNEYKAWE-VDTCRGHYNNVSSVL 259
               ...|:.|.:|||...:..  ..|.:::|:||...|:|   :|:... |.|..||.:|||:|.
plant   178 ---NFTLDAHQKGVNCVDYFTGGDKPYLITGSDDHTAKVW---DYQTKSCVQTLDGHTHNVSAVC 236

  Fly   260 FHPRQDLILSNGEDRSIRVWDMTKRQCLFTFRRDN------ERFWILTAHPTLNLFAAGHDGGMV 318
            |||...:|::..||.::|:|..|      |:|.:|      ||.|.:....:......|:|.|.:
plant   237 FHPELPIIITGSEDGTVRIWHAT------TYRLENTLNYGLERVWAIGYIKSSRRVVIGYDEGTI 295

  Fly   319 VFKLERERPA----------YAVHGNIL----------YYVKERFLRKL---DFTTTKDTVVMQL 360
            :.||.||.|.          :|.|..|.          |.:...:||.|   ||..        |
plant   296 MVKLGREIPVASMDSSGKIIWAKHNEIQTANIKSIGAGYELSSLYLRLLMEKDFPC--------L 352

  Fly   361 RPGKSPV---------YSMSYNPALNAVLICTRTNNLENSTYDLCQIPKDTESQSESDSKRSSGI 416
            .....||         .|:.:||....|::|   .:.|...|         .:.:..:....||:
plant   353 LKSWGPVIFIHNYSNSQSLKHNPNGRFVVVC---GDGEYIIY---------TALAWRNRSFGSGL 405

  Fly   417 TAIWVARNRFAVLDRNQQLVI--KNFKNEVTKKLPTFCEEIFYAGTGMLLIRDPEFVTLYEVQRL 479
            ..:|.:....||.:.:.::.|  |||:...:.: |||..|..:.|| :|.:...:|:..|:
plant   406 EFVWSSEGECAVRESSSKIKIFSKNFQERKSIR-PTFSAEKIFGGT-LLAMCSNDFICFYD---- 464

  Fly   480 VSVGSIKLAKCRYV----------VWSPDMSLVALLCKHSVTICDRRLQYLCT------------ 522
                   .|:||.:          .|:....|||:....|..|.....:.:.:
plant   465 -------WAECRLIQQIDVTVKNLYWAESGDLVAIASDTSFYILKYNRELVSSHFDSGRPTDEEG 522

  Fly   523 -------VQENC-RVKSGAWDESGVFIYTTSN-HIKYAITNGDHGIIRTLDLPIYLTRVKGNQ-- 576
                   :.||. ||::|.| ....|||..|: .:.|.: .|:...:..||.|:||.....||
plant   523 VEDAFEVLHENDERVRTGIW-VGDCFIYNNSSWKLNYCV-GGEVTTMYHLDRPMYLLGYIANQSR 585

  Fly   577 VFCLDRECRT--RVLHIDPTEYKFKLALIQR----KYDEVLHMVRNARLVGQSIIAYLQQKGYPE 635
            |:.:|:|...  ..|.:...|||   .|:.|    :.:::|..:...:  ..::..:|:.:|..|
plant   586 VYLVDKEFNVIGYTLLLSLIEYK---TLVMRGDLDRANQILPTIPKEQ--HNNVAHFLESRGMIE 645

  Fly   636 VALHFVKDEKTRFGLALECGNIEIALEAAKALDDKDCWDRLGQSALLQGNHQVVEMCYQRTKNFD 700
            .||....|...:|.||::.|.:|||.|.|:.:..:..|.:||:.|:..|..|:.|.|.:...:..
plant   646 DALEIATDPDYKFDLAIQLGRLEIAKEIAEEVQSESKWKQLGELAMSSGKLQLAEDCMKYAMDLS 710

  Fly   701 KLSFLYLITGNLEKLKKMNKIAEIRKDVSAQYQGALLLGDVKERVNILKNCGQLSLAYLTAATHG 765
            .|..||...|:.|.:.|:..:|:.:...:..:.....||.:::.:.:|....::..|.|.|.::
plant   711 GLLLLYSSLGDAEGVSKLACLAKEQGKNNVAFLCLFTLGRLEDCLQLLVESNRIPEAALMARSY- 774

  Fly   766 FDELTESLGESITSQGNSLPEVNPN-AQLLQPPVPIQQLETNWPL-LSVSKGFFEGAMVTRAGS- 827
               |...:.|.:......|.:|||. |:.|..|.....|..:|.: |||.....|...|..|..
plant   775 ---LPSKVSEIVALWREDLSKVNPKAAESLADPEEYSNLFEDWQVALSVEANTAETRGVYTAAEN 836

  Fly   828 --------SATARQA---LNINADAALLDEHNGGGDGWGADADLGLDEDGDDE------------ 869
                    |.|..:|   |.:.|:.:|   .||..|...|:.:..::.:||:|
plant   837 YPSHADKPSITLVEAFRNLQVEAEESL---ENGNIDHEVAEENGHVENEGDEEEQQEEEVNEEEG 898

  Fly   870 MHDALSNDGD---GGAGGEEGAG 889
            :.||.|.||.   .|:.|||..|
plant   899 VVDADSTDGAVLVNGSEGEEEWG 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaCOP	NP_477395.1	WD40	<2..320	CDD:225201	104/325 (32%)
		WD40	5..321	CDD:238121	104/326 (32%)
		WD40 repeat	15..49	CDD:293791	14/33 (42%)
		WD40 repeat	57..91	CDD:293791	9/33 (27%)
		WD40 repeat	97..133	CDD:293791	14/36 (39%)
		WD40 repeat	138..205	CDD:293791	13/67 (19%)
		WD40 repeat	212..249	CDD:293791	10/39 (26%)
		WD40 repeat	255..291	CDD:293791	13/35 (37%)
		WD40 repeat	299..352	CDD:293791	17/75 (23%)
		Coatomer_WDAD	354..765	CDD:281977	102/460 (22%)
		COPI_C	815..1228	CDD:284395	26/102 (25%)
AT3G15980	NP_001189908.1	WD40	17..297	CDD:238121	102/319 (32%)
		WD40 repeat	20..55	CDD:293791	14/34 (41%)
		WD40	24..447	CDD:225201	136/483 (28%)
		WD40 repeat	62..97	CDD:293791	9/34 (26%)
		WD40 repeat	103..140	CDD:293791	14/36 (39%)
		WD40 repeat	145..182	CDD:293791	13/67 (19%)
		WD40 repeat	189..226	CDD:293791	10/39 (26%)
		WD40 repeat	232..264	CDD:293791	14/37 (38%)
		Coatomer_WDAD	320..776	CDD:281977	109/499 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D139008at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920