DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alphaCOP and copb2

DIOPT Version :9

Sequence 1:	NP_477395.1	Gene:	alphaCOP / 38199	FlyBaseID:	FBgn0025725	Length:	1234	Species:	Drosophila melanogaster
Sequence 2:	NP_001027518.1	Gene:	copb2 / 613110	XenbaseID:	XB-GENE-964668	Length:	920	Species:	Xenopus tropicalis

Alignment Length:	967	Identity:	250/967 - (25%)
Similarity:	423/967 - (43%)	Gaps:	163/967 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SKSARVKGLSFHPKRPWILVSLHSGVIQLWDYRMHTLLEKFDEHDGPVRGVAFHQQMPLFVSGGD 71
            ::|.|||.:..||..||:|.||::|.:.:|::...||::.|:..|.|||...|..:....|:|.|
Frog    13 ARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKNWVVTGAD 77

  Fly    72 DYKIKVWNYKQRRCIFTLLAHLDYVRTVAFHHEYPWILSASDDQTIRIWNWQSR-NCICVLTGHN 135
            |.:|:|:||.....:....||.||:|.:|.|...|:||::|||..|::|:|..: :|..|..||.
Frog    78 DMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHT 142

  Fly   136 HYVMCAQFHPTE-DQIVSASLDQTVRVWDISGLRKKNVAPGPGGLDDHLKGHPGATDLFGQADAV 199
            ||||....:|.: :|..|||||:|::||.:.                  ...|..|
Frog   143 HYVMQIVINPKDNNQFASASLDRTIKVWQLG------------------SSSPNFT--------- 180

  Fly   200 VKHVLEGHDRGVNWASFHP--TLPLIVSGADDRLVKLWRMNEYKAWEVDTCRGHYNNVSSVLFHP 262
                ||||::|||...::.  ..|.::|||||||||:|.......  |.|..||..|||.|.|||
Frog   181 ----LEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTC--VQTLEGHAQNVSCVSFHP 239

  Fly   263 RQDLILSNGEDRSIRVWDMTKRQCLFTFRRDNERFWILTAHPTLNLFAAGHDGGMVVFKLERERP 327
            ...:|::..||.::|:|..:..:...|.....||.|.::.....|..|.|:|.|.::.||.||.|
Frog   240 ELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVSGLRGSNNVALGYDEGSIIVKLGREEP 304

  Fly   328 AYAV--HGNILY----YVKERFLRKLDFTTTKDTVVMQLR---PGKSPVY--SMSYNPALNAVLI 381
            |.::  :|.|::    .:::..|:.:..|..||...:.|.   .|...:|  ::.:||....|::
Frog   305 AMSMDANGKIIWAKHSEIQQANLKAMGDTEIKDGERLPLAVKDMGSCEIYPQTIQHNPNGRFVVV 369

  Fly   382 C-------TRTNNLENSTYDLCQIPKDTESQSESDSKRSSGITAIWVARNRFAVLDRNQQL-VIK 438
            |       .....|.|.::...|     |.....||             :.:|:.:.|..: :.|
Frog   370 CGDGEYIIYTAMALRNKSFGSAQ-----EFAWAHDS-------------SEYAIRESNSLVKIFK 416

  Fly   439 NFKNEVTKKLPTFCEEIFYAGTGMLLIRDPEFVTLYEVQRLVSVGSIKLAKCRYVVWSPDMSLVA 503
            |||.:.:.| |.|..|..|.|. :|.:|....:..|:.:....:..|:: :.:::.||....||.
Frog   417 NFKEKKSFK-PDFGAEGIYGGF-LLGVRSVNGLAFYDWENTELIRRIEI-QPKHIFWSDSGELVC 478

  Fly   504 LLCKHSVTICDRRLQYLCTVQENCR--------------------VKSGAWDESGVFIYT-TSNH 547
            :..:.|..|.....:.:.|.||...                    ||:|.| ....|||| |.|.
Frog   479 IATEESFFILKYLSEKVATAQETHEGVSEDGIEDAFEVLGEIQEIVKTGLW-VGDCFIYTSTVNR 542

  Fly   548 IKYAITNGDHGIIRTLDLPIYLTRV--KGNQVFCLDRECRTRVLHIDPTEYKFKLALIQRKY--- 607
            :.|.: .|:...|..||..:||...  |.|:::..|:|.......:..:..:::.|:::|.:
Frog   543 LNYYV-GGEIVTIAHLDRTMYLLGYIPKDNRLYLGDKELNIVSYSLLVSVLEYQTAVMRRDFSMA 606

  Fly   608 DEVLHMVRNARLVGQSIIAYLQQKGYPEVALHFVKDEKTRFGLALECGNIEIALEAAKALDDKDC 672
            |:|:..:...:..  .:..:|:::|:.:.||....|.:.||.|||:.|.::||.:.|...:.:..
Frog   607 DKVIPTIPKEQRT--RVAHFLEKQGFKQQALAVSTDPEHRFELALQLGELKIAYQLAVEAESEQK 669

  Fly   673 WDRLGQSALLQGNHQVVEMCYQRTKNFDKLSFLYLITGNLEKLKKMNKIAEIRKDVSAQYQGALL 737
            |.:|.:.|:.:....:.:.|....:::..|..|...:||...:.|:.:.||.....:..:....|
Frog   670 WKQLAELAISKCQFGLAQECLHSAQDYGGLLLLATSSGNATMVNKLAEGAEKDGKNNVAFLSYFL 734

  Fly   738 LGDVKERVNILKNCGQLSLAYLTAATHGFDELT-------ESLGESITSQGNSL----------- 784
            ||.:...:.:|.:.|:|..|...|.|:...:::       ||||:......:||
Frog   735 LGKLDSCLELLISTGRLPEAAFLARTYLPSQVSRVVKLWKESLGKVNQKAADSLADPTAYENLFP 799

  Fly   785 ---------PEVNPNAQLLQPPVPIQQLETNWP--LLSVSKGF--FEGAM-VTRAGSSATARQAL 835
                     |.:..|:.:|.|....:.:..|..  :||.:|||  .|.|. .....|.....||:
Frog   800 GLREAYAAEPFLKQNSGILLPAKEYRHVTPNEERNILSEAKGFDPSESAFTAVEKESVEVPNQAV 864

  Fly   836 NI-------------------NADAALLDEHNGGGDGWGAD----ADLGLDEDGDDE 869
            .|                   :.|.||.|... ..|....|    .|:.||::..||
Frog   865 PIPFAVPSPSIPAPEMPAPKSSMDKALFDLEE-DLDNMELDDIDTTDINLDDELSDE 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaCOP	NP_477395.1	WD40	<2..320	CDD:225201	108/316 (34%)
		WD40	5..321	CDD:238121	108/317 (34%)
		WD40 repeat	15..49	CDD:293791	12/33 (36%)
		WD40 repeat	57..91	CDD:293791	9/33 (27%)
		WD40 repeat	97..133	CDD:293791	14/36 (39%)
		WD40 repeat	138..205	CDD:293791	14/67 (21%)
		WD40 repeat	212..249	CDD:293791	14/38 (37%)
		WD40 repeat	255..291	CDD:293791	12/35 (34%)
		WD40 repeat	299..352	CDD:293791	15/58 (26%)
		Coatomer_WDAD	354..765	CDD:281977	98/449 (22%)
		COPI_C	815..1228	CDD:284395	19/81 (23%)
copb2	NP_001027518.1	Coatomer_WDAD	319..763	CDD:367786	101/468 (22%)
		WD40	8..297	CDD:238121	108/316 (34%)
		WD40 repeat	19..55	CDD:293791	13/35 (37%)
		WD40 repeat	103..140	CDD:293791	14/36 (39%)
		WD40 repeat	145..182	CDD:293791	14/67 (21%)
		WD40 repeat	189..226	CDD:293791	14/38 (37%)
		WD40 repeat	232..262	CDD:293791	11/29 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122926at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920