DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alphaCOP and Copb2

DIOPT Version :9

Sequence 1:	NP_477395.1	Gene:	alphaCOP / 38199	FlyBaseID:	FBgn0025725	Length:	1234	Species:	Drosophila melanogaster
Sequence 2:	NP_056642.1	Gene:	Copb2 / 50797	MGIID:	1354962	Length:	905	Species:	Mus musculus

Alignment Length:	972	Identity:	246/972 - (25%)
Similarity:	414/972 - (42%)	Gaps:	196/972 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SKSARVKGLSFHPKRPWILVSLHSGVIQLWDYRMHTLLEKFDEHDGPVRGVAFHQQMPLFVSGGD 71
            ::|.|||.:..||..||:|.||::|.:.:|::...||::.|:..|.|||...|..:....|:|.|
Mouse    13 ARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKNWVVTGAD 77

  Fly    72 DYKIKVWNYKQRRCIFTLLAHLDYVRTVAFHHEYPWILSASDDQTIRIWNWQSR-NCICVLTGHN 135
            |.:|:|:||.....:....||.||:|.:|.|...|:||::|||..|::|:|..: :|..|..||.
Mouse    78 DMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHT 142

  Fly   136 HYVMCAQFHPTE-DQIVSASLDQTVRVWDISGLRKKNVAPGPGGLDDHLKGHPGATDLFGQADAV 199
            ||||....:|.: :|..|||||:|::||.:.                  ...|..|
Mouse   143 HYVMQIVINPKDNNQFASASLDRTIKVWQLG------------------SSSPNFT--------- 180

  Fly   200 VKHVLEGHDRGVNWASFHP--TLPLIVSGADDRLVKLWRMNEYKAWEVDTCRGHYNNVSSVLFHP 262
                ||||::|||...::.  ..|.::|||||||||:|.......  |.|..||..|||...|||
Mouse   181 ----LEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTC--VQTLEGHAQNVSCASFHP 239

  Fly   263 RQDLILSNGEDRSIRVWDMTKRQCLFTFRRDNERFWILTAHPTLNLFAAGHDGGMVVFKLERERP 327
            ...:|::..||.::|:|..:..:...|.....||.|.:.:....|..|.|:|.|.::.||.||.|
Mouse   240 ELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSIIVKLGREEP 304

  Fly   328 AYAV--HGNILY----YVKERFLRKLDFTTTKDTVVMQLR---PGKSPVY--SMSYNPALNAVLI 381
            |.::  :|.|::    .|::..|:.:..|..||...:.|.   .|...:|  ::.:||....|::
Mouse   305 AMSMDANGKIIWAKHSEVQQANLKAMGDTEIKDGERLPLAVKDMGSCEIYPQTIQHNPNGRFVVV 369

  Fly   382 C-------TRTNNLENSTYDLCQIPKDTESQSESDSKRSSGITAIWVARNRFAVLDRNQQLVIKN 439
            |       .....|.|.::...|........||...:.|:.|..|:                 ||
Mouse   370 CGDGEYIIYTAMALRNKSFGSAQEFAWAHDSSEYAIRESNSIVKIF-----------------KN 417

  Fly   440 FKNEVTKKLPTFCEEIFYAGTGMLLIRDPEFVTLYEVQRLVSVGSIKLAKCRYVVWSPDMSLVAL 504
            ||.:.:.| |.|..|..|.|. :|.:|....:..|:.:....:..|:: :.:::.||....||.:
Mouse   418 FKEKKSFK-PDFGAESIYGGF-LLGVRSVNGLAFYDWENTELIRRIEI-QPKHIFWSDSGELVCI 479

  Fly   505 LCKHSVTICDRRLQYLC--------------------------TVQENCRVKSGAWDESGVFIYT 543
            ..:.|..|    |:||.                          .:||  .||:|.| ....||||
Mouse   480 ATEESFFI----LKYLSEKVLAAQETHEGVTEDGIEDAFEVLGEIQE--IVKTGLW-VGDCFIYT 537

  Fly   544 TS-NHIKYAITNGDHGIIRTLDLPIYLTRV--KGNQVFCLDRECRTRVLHIDPTEYKFKLALIQR 605
            :| |.:.|.: .|:...|..||..:||...  |.|:::..|:|.......:..:..:::.|:::|
Mouse   538 SSVNRLNYYV-GGEIVTIAHLDRTMYLLGYIPKDNRLYLGDKELNIVSYSLLVSVLEYQTAVMRR 601

  Fly   606 KY---DEVLHMVRNARLVGQSIIAYLQQKGYPEVALHFVKDEKTRFGLALECGNIEIALEAAKAL 667
            .:   |:||..:...:..  .:..:|:::|:.:.||....|.:.||.|||:.|.::||.:.|...
Mouse   602 DFSMADKVLPTIPKEQRT--RVAHFLEKQGFKQQALTVSTDPEHRFELALQLGELKIAYQLAVEA 664

  Fly   668 DDKDCWDRLGQSALLQGNHQVVEMCYQRTKNFDKLSFLYLITGNLEKLKKMNKIAEIRKDVSAQY 732
            :.:..|.:|.:.|:.:....:.:.|....:::..|..|...:||...:.|:.:.||.....:..:
Mouse   665 ESEQKWKQLAELAISKCQFSLAQECLHHAQDYGGLLLLATASGNASMVNKLAEGAERDGKNNVAF 729

  Fly   733 QGALLLGDVKERVNILKNCGQLSLAYLTAATHGFDELTESLGESITSQGNSLPEVNPN-AQLLQP 796
            ....|.|.:...:.:|...|:|..|...|.|:    |...:...:.....:|.:||.. |:.|..
Mouse   730 MSYFLQGKLDACLELLIRTGRLPEAAFLARTY----LPSQVSRVVKLWRENLSKVNQKAAESLAD 790

  Fly   797 PVPIQQL---------------ETN---WP--------------LLSVSKGFFEGAMVTRAGSSA 829
            |...:.|               ||:   ||              ::..:|||        ..|..
Mouse   791 PTEYENLFPGLKEAFVVEEWVKETHADLWPAKQYPLVTPNEERNVMEEAKGF--------QPSRP 847

  Fly   830 TARQ--------------------------ALNINADAALLDEHNGGGDGWGADADLGLDED 865
            ||:|                          .|.::.|...|::.:        ..|:.||||
Mouse   848 TAQQEPDGKPASSPVIMASQTTHKEEKSLLELEVDLDNLELEDID--------TTDINLDED 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaCOP	NP_477395.1	WD40	<2..320	CDD:225201	107/316 (34%)
		WD40	5..321	CDD:238121	107/317 (34%)
		WD40 repeat	15..49	CDD:293791	12/33 (36%)
		WD40 repeat	57..91	CDD:293791	9/33 (27%)
		WD40 repeat	97..133	CDD:293791	14/36 (39%)
		WD40 repeat	138..205	CDD:293791	14/67 (21%)
		WD40 repeat	212..249	CDD:293791	14/38 (37%)
		WD40 repeat	255..291	CDD:293791	11/35 (31%)
		WD40 repeat	299..352	CDD:293791	16/58 (28%)
		Coatomer_WDAD	354..765	CDD:281977	100/454 (22%)
		COPI_C	815..1228	CDD:284395	14/77 (18%)
Copb2	NP_056642.1	WD40	8..297	CDD:238121	107/316 (34%)
		WD 1	13..52		15/38 (39%)
		WD40 repeat	19..55	CDD:293791	13/35 (37%)
		WD 2	55..94		13/38 (34%)
		WD 3	97..136		17/38 (45%)
		WD40 repeat	103..140	CDD:293791	14/36 (39%)
		WD 4	140..180		17/57 (30%)
		WD40 repeat	145..182	CDD:293791	14/67 (21%)
		WD 5	183..224		17/42 (40%)
		WD40 repeat	189..226	CDD:293791	14/38 (37%)
		WD 6	227..266		13/38 (34%)
		WD40 repeat	232..268	CDD:293791	11/35 (31%)
		Coatomer_WDAD	319..763	CDD:397941	104/477 (22%)
		WD 7	350..388		7/37 (19%)
		WD 8	390..425		10/51 (20%)
		WD 9	746..783		9/40 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	837..873		7/43 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122926at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920