DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alphaCOP and Copa

DIOPT Version :9

Sequence 1:	NP_477395.1	Gene:	alphaCOP / 38199	FlyBaseID:	FBgn0025725	Length:	1234	Species:	Drosophila melanogaster
Sequence 2:	NP_001128012.1	Gene:	Copa / 304978	RGDID:	1310525	Length:	1224	Species:	Rattus norvegicus

Alignment Length:	1241	Identity:	876/1241 - (70%)
Similarity:	1016/1241 - (81%)	Gaps:	24/1241 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLTNFESKSARVKGLSFHPKRPWILVSLHSGVIQLWDYRMHTLLEKFDEHDGPVRGVAFHQQMPL 65
            |||.||:||||||||||||||||||.|||:||||||||||.||::|||||||||||:.||:|.||
  Rat     1 MLTKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPL 65

  Fly    66 FVSGGDDYKIKVWNYKQRRCIFTLLAHLDYVRTVAFHHEYPWILSASDDQTIRIWNWQSRNCICV 130
            ||||||||||||||||.|||:||||.||||:||..||||||||||||||||||:||||||.|:||
  Rat    66 FVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCV 130

  Fly   131 LTGHNHYVMCAQFHPTEDQIVSASLDQTVRVWDISGLRKKNVAPGPGGLDDHLKGHPGATDLFGQ 195
            |||||||||||||||:||.:|||||||||||||||||||||::  ||.::..::|..| .||||.
  Rat   131 LTGHNHYVMCAQFHPSEDLVVSASLDQTVRVWDISGLRKKNLS--PGAVESDVRGITG-VDLFGT 192

  Fly   196 ADAVVKHVLEGHDRGVNWASFHPTLPLIVSGADDRLVKLWRMNEYKAWEVDTCRGHYNNVSSVLF 260
            .||||||||||||||||||:||||:||||||||||.||:|||||.||||||||||||||||..:|
  Rat   193 TDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVF 257

  Fly   261 HPRQDLILSNGEDRSIRVWDMTKRQCLFTFRRDNERFWILTAHPTLNLFAAGHDGGMVVFKLERE 325
            ||||:|||||.||:|||||||:||..:.|||||::|||:|.|||.||||||||||||:|||||||
  Rat   258 HPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLNLFAAGHDGGMIVFKLERE 322

  Fly   326 RPAYAVHGNILYYVKERFLRKLDFTTTKDTVVMQLRPG-KSPVYSMSYNPALNAVLICTRTNNLE 389
            |||||||||:|:|||:||||:|||.::||..|||||.| |.||::||||||.||||:|||.:|||
  Rat   323 RPAYAVHGNMLHYVKDRFLRQLDFNSSKDVAVMQLRSGSKFPVFNMSYNPAENAVLLCTRASNLE 387

  Fly   390 NSTYDLCQIPKDTESQSES--DSKRSSGITAIWVARNRFAVLDRNQQLVIKNFKNEVTKKL--PT 450
            ||||||..||||.:||:..  :.|||||:||:||||||||||||...|:|||.|||:|||:  |.
  Rat   388 NSTYDLYTIPKDADSQNPDAPEGKRSSGLTAVWVARNRFAVLDRMHSLLIKNLKNEITKKIQVPN 452

  Fly   451 FCEEIFYAGTGMLLIRDPEFVTLYEVQRLVSVGSIKLAKCRYVVWSPDMSLVALLCKHSVTICDR 515
             |:||||||||.||:||.:.:||::||:..::.|:|::|.:||:||.|||.||||.||::.||:|
  Rat   453 -CDEIFYAGTGNLLLRDADSITLFDVQQKRTLASVKISKVKYVIWSADMSHVALLAKHAIVICNR 516

  Fly   516 RLQYLCTVQENCRVKSGAWDESGVFIYTTSNHIKYAITNGDHGIIRTLDLPIYLTRVKGNQVFCL 580
            :|..||.:.||.||||||||||||||||||||||||:|.||||||||||||||:||||||.|:||
  Rat   517 KLDALCNIHENIRVKSGAWDESGVFIYTTSNHIKYAVTTGDHGIIRTLDLPIYVTRVKGNNVYCL 581

  Fly   581 DRECRTRVLHIDPTEYKFKLALIQRKYDEVLHMVRNARLVGQSIIAYLQQKGYPEVALHFVKDEK 645
            |||||.|||.|||||:|||||||.|||||||||||||:|||||||||||:|||||||||||||||
  Rat   582 DRECRPRVLTIDPTEFKFKLALINRKYDEVLHMVRNAKLVGQSIIAYLQKKGYPEVALHFVKDEK 646

  Fly   646 TRFGLALECGNIEIALEAAKALDDKDCWDRLGQSALLQGNHQVVEMCYQRTKNFDKLSFLYLITG 710
            |||.|||||||||||||||||||||:||::||:.||||||||:||||||||||||||||||||||
  Rat   647 TRFSLALECGNIEIALEAAKALDDKNCWEKLGEVALLQGNHQIVEMCYQRTKNFDKLSFLYLITG 711

  Fly   711 NLEKLKKMNKIAEIRKDVSAQYQGALLLGDVKERVNILKNCGQLSLAYLTAATHGFDELTESLGE 775
            |||||:||.||||||||:|..||.||.||||.|||.|||||||.|||||||||||.||..|||.|
  Rat   712 NLEKLRKMMKIAEIRKDMSGHYQNALYLGDVSERVRILKNCGQKSLAYLTAATHGLDEEAESLKE 776

  Fly   776 SITSQGNSLPEVNPNAQLLQPPVPIQQLETNWPLLSVSKGFFEGAMVTRAGSSATARQALNINAD 840
            :...:..::|:::|||:|||||.||..|:||||||:||||||||::.::....|.|       ||
  Rat   777 TFDPEKETIPDIDPNAKLLQPPAPIMPLDTNWPLLTVSKGFFEGSIASKGKGGALA-------AD 834

  Fly   841 AALLDEHNGGGDGWGADADLGLDEDGDDEMHDALSNDGDGGAGGEEGAGWDVGDDDLVVPEEL-- 903
               :|....|.:|||.||:|.|||||..|..:.|..| ..|.|.|||.|||| ::||.:|.||
  Rat   835 ---IDIDTVGTEGWGEDAELQLDEDGFVEAPEGLGED-TLGKGQEEGGGWDV-EEDLELPPELDV 894

  Fly   904 ASKIKASALDSNYYAAPNKGLSPAQQWANNSPLVLDHVKAGSFETAFRLLHDQLGVVNFQPFKTL 968
            .|.:...|.| .::..|.||.||.|.|.|||.|.:||:.|||||||.||||||:|||.|.|:|.|
  Rat   895 PSGVAGGAED-GFFVPPTKGTSPTQIWCNNSQLPVDHILAGSFETAMRLLHDQVGVVQFGPYKQL 958

  Fly   969 FLQNYACSRTSYTANPNLQSLSGYPLRNYSETNIKLQRPAVGIKLNDLVARLQAGYQLTTSGKFS 1033
            |||.||..||:|.|.|.|.|:..||.||:.:..:|...||||:|||||:.|||..|||:|.|||.
  Rat   959 FLQTYARGRTTYQALPCLPSMYSYPNRNWKDAGLKNGVPAVGLKLNDLIQRLQLCYQLSTVGKFE 1023

  Fly  1034 EAVEKFHSILISIPLLVVDTKLDAAEAQQLLRICAEYIVGLKMETVRKGMPKSTLEEQKRLCEMA 1098
            :|||||.|||:|:||||||.|.:.||||||:.||.||||||.||..||.:||.||::|||:||||
  Rat  1024 DAVEKFRSILLSVPLLVVDNKQEIAEAQQLITICREYIVGLCMEIERKKLPKETLDQQKRICEMA 1088

  Fly  1099 AYFTHCKLQPVHQILTLRTALNMFFKLKNYKTAASFARRLLELAPRPDVAQQVRKILQACEVNPV 1163
            |||||..|||||.||.||||||:||||||:||||:||||||||.|:|:||||.||||.|||.||.
  Rat  1089 AYFTHSNLQPVHMILVLRTALNLFFKLKNFKTAATFARRLLELGPKPEVAQQTRKILSACEKNPT 1153

  Fly  1164 DEHQLQYEEFNPFTICGISWKPLYRGKPEVTCPFCSSSFDPQFKGNLCTVCEVSQIGKDSIGLRI 1228
            |..||.|:..|||.||..|::|:|||||...||...:.:.|:|||.:|.|..|::||||.|||||
  Rat  1154 DACQLNYDMHNPFDICAASYRPIYRGKPVEKCPLSGACYSPEFKGQICRVTTVTEIGKDVIGLRI 1218

  Fly  1229 SNLQFR 1234
            |.||||
  Rat  1219 SPLQFR 1224

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaCOP	NP_477395.1	WD40	<2..320	CDD:225201	255/317 (80%)
		WD40	5..321	CDD:238121	254/315 (81%)
		WD40 repeat	15..49	CDD:293791	28/33 (85%)
		WD40 repeat	57..91	CDD:293791	27/33 (82%)
		WD40 repeat	97..133	CDD:293791	30/35 (86%)
		WD40 repeat	138..205	CDD:293791	46/66 (70%)
		WD40 repeat	212..249	CDD:293791	31/36 (86%)
		WD40 repeat	255..291	CDD:293791	24/35 (69%)
		WD40 repeat	299..352	CDD:293791	43/52 (83%)
		Coatomer_WDAD	354..765	CDD:281977	317/415 (76%)
		COPI_C	815..1228	CDD:284395	239/414 (58%)
Copa	NP_001128012.1	WD40	<1..171	CDD:225201	146/169 (86%)
		WD40	9..318	CDD:238121	251/311 (81%)
		WD40 repeat	15..49	CDD:293791	28/33 (85%)
		WD40 repeat	55..91	CDD:293791	29/35 (83%)
		WD40 repeat	96..132	CDD:293791	29/35 (83%)
		WD40	99..504	CDD:225201	296/408 (73%)
		WD40 repeat	139..202	CDD:293791	45/65 (69%)
		WD40 repeat	208..241	CDD:293791	27/32 (84%)
		WD40 repeat	249..278	CDD:293791	22/28 (79%)
		Coatomer_WDAD	339..767	CDD:281977	326/428 (76%)
		WD40 repeat	365..406	CDD:293791	29/40 (73%)
		COPI_C	816..1218	CDD:284395	239/414 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353900
Domainoid	1	1.000	634	1.000	Domainoid score	I163
eggNOG	1	0.900	-	-		E1_KOG0292
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3218
Inparanoid	1	1.050	1773	1.000	Inparanoid score	I61
OMA	1	1.010	-	-		QHG53722
OrthoDB	1	1.010	-	-		D122926at33208
OrthoFinder	1	1.000	-	-		FOG0004006
OrthoInspector	1	1.000	-	-		oto97682
orthoMCL	1	0.900	-	-		OOG6_101600
Panther	1	1.100	-	-	LDO	PTHR19876
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2767
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770