DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alphaCOP and SPBPJ4664.04

DIOPT Version :9

Sequence 1:	NP_477395.1	Gene:	alphaCOP / 38199	FlyBaseID:	FBgn0025725	Length:	1234	Species:	Drosophila melanogaster
Sequence 2:	NP_595279.1	Gene:	SPBPJ4664.04 / 2541412	PomBaseID:	SPBPJ4664.04	Length:	1207	Species:	Schizosaccharomyces pombe

Alignment Length:	1247	Identity:	579/1247 - (46%)
Similarity:	769/1247 - (61%)	Gaps:	65/1247 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLTNFESKSARVKGLSFHPKRPWILVSLHSGVIQLWDYRMHTLLEKFDEHDGPVRGVAFHQQMPL 65
            |||.|||:|:|.||::|||.:||||.|||:|.||||||||.|||::||.|||||||:|||...||
pombe     3 MLTKFESRSSRAKGVAFHPTQPWILTSLHNGRIQLWDYRMGTLLDRFDGHDGPVRGIAFHPTQPL 67

  Fly    66 FVSGGDDYKIKVWNYKQRRCIFTLLAHLDYVRTVAFHHEYPWILSASDDQTIRIWNWQSRNCICV 130
            |||||||||:.|||||.|:.:|:|..|:||||...||||||||||.|||||||||||||||||.:
pombe    68 FVSGGDDYKVNVWNYKSRKLLFSLCGHMDYVRVCTFHHEYPWILSCSDDQTIRIWNWQSRNCIAI 132

  Fly   131 LTGHNHYVMCAQFHPTEDQIVSASLDQTVRVWDISGLRKKNVAPGPGGLDDHL-KGHPG-ATDLF 193
            ||||:||||||.|||:||.|||||||||||||||||||.||.||....|:|.| :.|.. :.|||
pombe   133 LTGHSHYVMCAAFHPSEDLIVSASLDQTVRVWDISGLRMKNAAPVSMSLEDQLAQAHNSISNDLF 197

  Fly   194 GQADAVVKHVLEGHDRGVNWASFHPTLPLIVSGADDRLVKLWRMNEYKAWEVDTCRGHYNNVSSV 258
            |..||:||.|||||||||||.:||||||||:|..||||||||||...|||||||||||:||||..
pombe   198 GSTDAIVKFVLEGHDRGVNWCAFHPTLPLILSAGDDRLVKLWRMTASKAWEVDTCRGHFNNVSCC 262

  Fly   259 LFHPRQDLILSNGEDRSIRVWDMTKRQCLFTFRRDNERFWILTAHPTLNLFAAGHDGGMVVFKLE 323
            ||||.|:||||..||::|||||:.:|..:.||||||:|||.:|.||.||||||.||.|::|||||
pombe   263 LFHPHQELILSASEDKTIRVWDLNRRTAVQTFRRDNDRFWFITVHPKLNLFAAAHDSGVMVFKLE 327

  Fly   324 RERPAYAVHGNILYYV-KERFLRKLDFTTTKDTVVMQLRPGKS---PVYSMSYNPALNAVLICTR 384
            |||||:|::.|.|.|| ||:.:...|....:.|.|..::...|   |..|:|||||....|:
pombe   328 RERPAHALNINTLLYVNKEKSIVSYDLLRAQSTTVASVKHLGSAWLPPRSLSYNPAEKVALL--- 389

  Fly   385 TNNLENSTYDLCQIPKDTESQSESDSKRSSGITAIWVARNRFAVLDRNQQLV-IKNFKNEVTK-- 446
            |::.:|..|:|..:...:.|....|:.:..|..||:||||||||..|:.|.: ||:..|:|||
pombe   390 TSSADNGVYELVNVSSRSNSLPLKDNIKGPGDDAIFVARNRFAVFSRSDQTIEIKDLSNKVTKTI 454

  Fly   447 KLPTFCEEIFYAGTGMLLIRDPEFVTLYEVQRLVSVGSIKLAKCRYVVWSPDMSLVALLCKHSVT 511
            :||....:||:||.|.:|:.....|.|:::|:...|.|....:.:|||||.|.|..|||.||.|.
pombe   455 QLPEKTRDIFFAGMGHVLLSTATQVHLFDLQQKKIVSSFNANRVKYVVWSNDNSQAALLGKHYVY 519

  Fly   512 ICDRRLQYLCTVQENCRVKSGAWDESGVFIYTTSNHIKYAITNGDHGIIRTLDLPIYLTRVKGNQ 576
            |..:.|:.:.::.|..|:||..|.|:.|.:|.|.:|:|||:.:||.|:|:||:..:||.:.|||.
pombe   520 IVKKNLELITSIHETIRIKSAVWVENNVLLYATLDHLKYALMSGDTGVIKTLESTLYLVKAKGNM 584

  Fly   577 VFCLDRECRTRVLHIDPTEYKFKLALIQRKYDEVLHMVRNARLVGQSIIAYLQQKGYPEVALHFV 641
            ||.|:|........||||||.|||||:::.|::|||:::|:.||||:||||||:|||||:||.||
pombe   585 VFALNRAAEPVSFEIDPTEYLFKLALLRKDYEQVLHLIQNSNLVGQAIIAYLQKKGYPEIALQFV 649

  Fly   642 KDEKTRFGLALECGNIEIALEAAKALDDKDCWDRLGQSALLQGNHQVVEMCYQRTKNFDKLSFLY 706
            :|..|||.|||||||:|.|||.|:.:|..:.|.||...|:..|||::.|:.:|:.:.|:||||||
pombe   650 EDPSTRFELALECGNLETALELARTIDRPEVWSRLASDAMSYGNHKIAEITFQKLRYFEKLSFLY 714

  Fly   707 LITGNLEKLKKMNKIAEIRKDVSAQYQGALLLGDVKERVNILKNCGQLSLAYLTAATHGFDELTE 771
            |||||.|||:||..|||.|.|..:.:|.:|.|.:|:.|:|||:..|...:|||||.::|.:|..:
pombe   715 LITGNAEKLQKMAIIAEKRNDTLSLFQNSLYLNEVESRINILEQAGMYPIAYLTAKSNGLEEKAQ 779

  Fly   772 SLGE--SITSQGNSLPEVNPNAQLLQPPVPIQQLET-NWPLLSVSKGFFEGAMVTRAGSSATARQ 833
            .:..  :.|.:...||.:   ......|||:.:..| |||||..|...||.::..|....|..||
pombe   780 QILSHCNKTEEEIKLPSL---GSAFTTPVPVNETYTHNWPLLDTSHSTFEKSLQERMEQLAIERQ 841

  Fly   834 ALNINADAALLDEHNGGGDGWGADADLGLDEDGDDEMHDALSNDGDGGAGGEEGAGWDVGDDDLV 898
                       :|.....:....:..|   .|..|||.|...:..:     ||..||:|.|   :
pombe   842 -----------EEQESEEEYEEVEQSL---MDVVDEMSDLAESVPE-----EEVDGWEVED---L 884

  Fly   899 VPEELASKI--KASALDSNYYAAPNKGLSPAQQWANNSPLVLDHVKAGSFETAFRLLHDQLGVVN 961
            .|||..:.:  .|||.         .|......|..||||..||:.||.||:|.::|:.|:|.:|
pombe   885 APEEAVNDVVDDASAF---------VGADEIFLWKRNSPLAADHIAAGDFESAMKILNKQVGAIN 940

  Fly   962 FQPFKTLFLQNYACSRTSYTANPNLQSLSGYPLRNYSETNIKLQ------RPAVGIKLNDLVARL 1020
            |.|.||.||:.|..||........|..|..|..|| :||..:.|      |....||.::    |
pombe   941 FSPLKTRFLEIYTASRVYLPTISGLDPLVSYVRRN-AETAERSQALPFITRNLASIKSHE----L 1000

  Fly  1021 QAGYQLTTSGKFSEAVEKFHSILISIPLLVVDTKLDAAEAQQLLRICAEYIVGLKMETVRKGMPK 1085
            ...|:|..:.|..||...|.||:......|.:::.:|.|...|:..|..|||.|..|..|:.:.:
pombe  1001 HEAYRLVKANKILEAQICFRSIIYLALTTVANSEEEADEISALIDECCRYIVALSCELERRRLGE 1065

  Fly  1086 STLEEQKRLCEMAAYFTHCKLQPVHQILTLRTALNMFFKLKNYKTAASFARRLLELAPRPDVAQQ 1150
               |:.||..|::.||....|||:|.|:.||.|:|...||||||:|:....:||:||.....|:.
pombe  1066 ---EDTKRALELSYYFASADLQPMHSIIALRLAINASHKLKNYKSASFLGNKLLQLAESGPAAEA 1127

  Fly  1151 VRKILQACEVNPVDEHQLQYEEFNPFTICGISWKPLYRGKPEVTCPFCSSSFDPQFKGNLCTVCE 1215
            ..:.:...:.||.|..:::|:......||..:..|:|.|.....|..|.:.:...:...:||||:
pombe  1128 ANRAITLGDRNPHDAFEIEYDPHVEMRICPKTLTPVYSGDDFDVCSVCGAVYHKGYVNEVCTVCD 1192

  Fly  1216 VSQIGKDSIGLR 1227
            |..||:...|.|
pombe  1193 VGGIGQKGTGRR 1204

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaCOP	NP_477395.1	WD40	<2..320	CDD:225201	227/319 (71%)
		WD40	5..321	CDD:238121	226/317 (71%)
		WD40 repeat	15..49	CDD:293791	23/33 (70%)
		WD40 repeat	57..91	CDD:293791	22/33 (67%)
		WD40 repeat	97..133	CDD:293791	29/35 (83%)
		WD40 repeat	138..205	CDD:293791	45/68 (66%)
		WD40 repeat	212..249	CDD:293791	28/36 (78%)
		WD40 repeat	255..291	CDD:293791	20/35 (57%)
		WD40 repeat	299..352	CDD:293791	30/53 (57%)
		Coatomer_WDAD	354..765	CDD:281977	189/416 (45%)
		COPI_C	815..1228	CDD:284395	129/421 (31%)
SPBPJ4664.04	NP_595279.1	WD40	1..508	CDD:225201	301/507 (59%)
		WD40	17..325	CDD:238121	219/307 (71%)
		WD40 repeat	17..51	CDD:293791	23/33 (70%)
		WD40 repeat	57..93	CDD:293791	24/35 (69%)
		WD40 repeat	98..134	CDD:293791	29/35 (83%)
		WD40 repeat	141..209	CDD:293791	44/67 (66%)
		WD40 repeat	216..248	CDD:293791	23/31 (74%)
		WD40 repeat	259..285	CDD:293791	17/25 (68%)
		WD40 repeat	303..369	CDD:293791	32/65 (49%)
		Coatomer_WDAD	347..774	CDD:281977	190/429 (44%)
		WD40 repeat	375..398	CDD:293791	9/25 (36%)
		WD40 repeat	424..455	CDD:293791	17/30 (57%)
		WD40 repeat	463..491	CDD:293791	9/27 (33%)
		COPI_C	858..1204	CDD:284395	120/370 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	365	1.000	Domainoid score	I145
eggNOG	1	0.900	-	-		E1_KOG0292
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3218
Inparanoid	1	1.050	1062	1.000	Inparanoid score	I28
OMA	1	1.010	-	-		QHG53722
OrthoFinder	1	1.000	-	-		FOG0004006
OrthoInspector	1	1.000	-	-		oto101566
orthoMCL	1	0.900	-	-		OOG6_101600
Panther	1	1.100	-	-	LDO	PTHR19876
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R225
SonicParanoid	1	1.000	-	-		X2767
TreeFam	1	0.960	-	-
	14	13.860