Protein Alignment alphaCOP and cop1

DIOPT Version :10

• Sequence 1: NP_477395.1
• Gene: alphaCOP / 38199
• FlyBaseID: FBgn0025725
• Length: 1234
• Species: Drosophila melanogaster
• Sequence 2: NP_595279.1
• Gene: cop1 / 2541412
• PomBaseID: SPBPJ4664.04
• Length: 1207
• Species: Schizosaccharomyces pombe
• Alignment Length: 1247
• Identity: 579/1247 - (46%)
• Similarity: 769/1247 - (61%)
• Gaps: 65/1247 - (5%)

  Fly     1 MLTNFESKSARVKGLSFHPKRPWILVSLHSGVIQLWDYRMHTLLEKFDEHDGPVRGVAFHQQMPL 65
            |||.|||:|:|.||::|||.:||||.|||:|.||||||||.|||::||.|||||||:|||...||
pombe     3 MLTKFESRSSRAKGVAFHPTQPWILTSLHNGRIQLWDYRMGTLLDRFDGHDGPVRGIAFHPTQPL 67

  Fly    66 FVSGGDDYKIKVWNYKQRRCIFTLLAHLDYVRTVAFHHEYPWILSASDDQTIRIWNWQSRNCICV 130
            |||||||||:.|||||.|:.:|:|..|:||||...||||||||||.|||||||||||||||||.:
pombe    68 FVSGGDDYKVNVWNYKSRKLLFSLCGHMDYVRVCTFHHEYPWILSCSDDQTIRIWNWQSRNCIAI 132

  Fly   131 LTGHNHYVMCAQFHPTEDQIVSASLDQTVRVWDISGLRKKNVAPGPGGLDDHL-KGHPG-ATDLF 193
            ||||:||||||.|||:||.|||||||||||||||||||.||.||....|:|.| :.|.. :.|||
pombe   133 LTGHSHYVMCAAFHPSEDLIVSASLDQTVRVWDISGLRMKNAAPVSMSLEDQLAQAHNSISNDLF 197

  Fly   194 GQADAVVKHVLEGHDRGVNWASFHPTLPLIVSGADDRLVKLWRMNEYKAWEVDTCRGHYNNVSSV 258
            |..||:||.|||||||||||.:||||||||:|..||||||||||...|||||||||||:||||..
pombe   198 GSTDAIVKFVLEGHDRGVNWCAFHPTLPLILSAGDDRLVKLWRMTASKAWEVDTCRGHFNNVSCC 262

  Fly   259 LFHPRQDLILSNGEDRSIRVWDMTKRQCLFTFRRDNERFWILTAHPTLNLFAAGHDGGMVVFKLE 323
            ||||.|:||||..||::|||||:.:|..:.||||||:|||.:|.||.||||||.||.|::|||||
pombe   263 LFHPHQELILSASEDKTIRVWDLNRRTAVQTFRRDNDRFWFITVHPKLNLFAAAHDSGVMVFKLE 327

  Fly   324 RERPAYAVHGNILYYV-KERFLRKLDFTTTKDTVVMQLRPGKS---PVYSMSYNPALNAVLICTR 384
            |||||:|::.|.|.|| ||:.:...|....:.|.|..::...|   |..|:|||||....|:
pombe   328 RERPAHALNINTLLYVNKEKSIVSYDLLRAQSTTVASVKHLGSAWLPPRSLSYNPAEKVALL--- 389

  Fly   385 TNNLENSTYDLCQIPKDTESQSESDSKRSSGITAIWVARNRFAVLDRNQQLV-IKNFKNEVTK-- 446
            |::.:|..|:|..:...:.|....|:.:..|..||:||||||||..|:.|.: ||:..|:|||
pombe   390 TSSADNGVYELVNVSSRSNSLPLKDNIKGPGDDAIFVARNRFAVFSRSDQTIEIKDLSNKVTKTI 454

  Fly   447 KLPTFCEEIFYAGTGMLLIRDPEFVTLYEVQRLVSVGSIKLAKCRYVVWSPDMSLVALLCKHSVT 511
            :||....:||:||.|.:|:.....|.|:::|:...|.|....:.:|||||.|.|..|||.||.|.
pombe   455 QLPEKTRDIFFAGMGHVLLSTATQVHLFDLQQKKIVSSFNANRVKYVVWSNDNSQAALLGKHYVY 519

  Fly   512 ICDRRLQYLCTVQENCRVKSGAWDESGVFIYTTSNHIKYAITNGDHGIIRTLDLPIYLTRVKGNQ 576
            |..:.|:.:.::.|..|:||..|.|:.|.:|.|.:|:|||:.:||.|:|:||:..:||.:.|||.
pombe   520 IVKKNLELITSIHETIRIKSAVWVENNVLLYATLDHLKYALMSGDTGVIKTLESTLYLVKAKGNM 584

  Fly   577 VFCLDRECRTRVLHIDPTEYKFKLALIQRKYDEVLHMVRNARLVGQSIIAYLQQKGYPEVALHFV 641
            ||.|:|........||||||.|||||:::.|::|||:::|:.||||:||||||:|||||:||.||
pombe   585 VFALNRAAEPVSFEIDPTEYLFKLALLRKDYEQVLHLIQNSNLVGQAIIAYLQKKGYPEIALQFV 649

  Fly   642 KDEKTRFGLALECGNIEIALEAAKALDDKDCWDRLGQSALLQGNHQVVEMCYQRTKNFDKLSFLY 706
            :|..|||.|||||||:|.|||.|:.:|..:.|.||...|:..|||::.|:.:|:.:.|:||||||
pombe   650 EDPSTRFELALECGNLETALELARTIDRPEVWSRLASDAMSYGNHKIAEITFQKLRYFEKLSFLY 714

  Fly   707 LITGNLEKLKKMNKIAEIRKDVSAQYQGALLLGDVKERVNILKNCGQLSLAYLTAATHGFDELTE 771
            |||||.|||:||..|||.|.|..:.:|.:|.|.:|:.|:|||:..|...:|||||.::|.:|..:
pombe   715 LITGNAEKLQKMAIIAEKRNDTLSLFQNSLYLNEVESRINILEQAGMYPIAYLTAKSNGLEEKAQ 779

  Fly   772 SLGE--SITSQGNSLPEVNPNAQLLQPPVPIQQLET-NWPLLSVSKGFFEGAMVTRAGSSATARQ 833
            .:..  :.|.:...||.:   ......|||:.:..| |||||..|...||.::..|....|..||
pombe   780 QILSHCNKTEEEIKLPSL---GSAFTTPVPVNETYTHNWPLLDTSHSTFEKSLQERMEQLAIERQ 841

  Fly   834 ALNINADAALLDEHNGGGDGWGADADLGLDEDGDDEMHDALSNDGDGGAGGEEGAGWDVGDDDLV 898
                       :|.....:....:..|   .|..|||.|...:..:     ||..||:|.|   :
pombe   842 -----------EEQESEEEYEEVEQSL---MDVVDEMSDLAESVPE-----EEVDGWEVED---L 884

  Fly   899 VPEELASKI--KASALDSNYYAAPNKGLSPAQQWANNSPLVLDHVKAGSFETAFRLLHDQLGVVN 961
            .|||..:.:  .|||.         .|......|..||||..||:.||.||:|.::|:.|:|.:|
pombe   885 APEEAVNDVVDDASAF---------VGADEIFLWKRNSPLAADHIAAGDFESAMKILNKQVGAIN 940

  Fly   962 FQPFKTLFLQNYACSRTSYTANPNLQSLSGYPLRNYSETNIKLQ------RPAVGIKLNDLVARL 1020
            |.|.||.||:.|..||........|..|..|..|| :||..:.|      |....||.::    |
pombe   941 FSPLKTRFLEIYTASRVYLPTISGLDPLVSYVRRN-AETAERSQALPFITRNLASIKSHE----L 1000

  Fly  1021 QAGYQLTTSGKFSEAVEKFHSILISIPLLVVDTKLDAAEAQQLLRICAEYIVGLKMETVRKGMPK 1085
            ...|:|..:.|..||...|.||:......|.:::.:|.|...|:..|..|||.|..|..|:.:.:
pombe  1001 HEAYRLVKANKILEAQICFRSIIYLALTTVANSEEEADEISALIDECCRYIVALSCELERRRLGE 1065

  Fly  1086 STLEEQKRLCEMAAYFTHCKLQPVHQILTLRTALNMFFKLKNYKTAASFARRLLELAPRPDVAQQ 1150
               |:.||..|::.||....|||:|.|:.||.|:|...||||||:|:....:||:||.....|:.
pombe  1066 ---EDTKRALELSYYFASADLQPMHSIIALRLAINASHKLKNYKSASFLGNKLLQLAESGPAAEA 1127

  Fly  1151 VRKILQACEVNPVDEHQLQYEEFNPFTICGISWKPLYRGKPEVTCPFCSSSFDPQFKGNLCTVCE 1215
            ..:.:...:.||.|..:::|:......||..:..|:|.|.....|..|.:.:...:...:||||:
pombe  1128 ANRAITLGDRNPHDAFEIEYDPHVEMRICPKTLTPVYSGDDFDVCSVCGAVYHKGYVNEVCTVCD 1192

  Fly  1216 VSQIGKDSIGLR 1227
            |..||:...|.|
pombe  1193 VGGIGQKGTGRR 1204

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alphaCOP	NP_477395.1	WD40	5..321	CDD:238121	226/317 (71%)
		WD40 repeat	15..49	CDD:293791	23/33 (70%)
		WD40 repeat	57..91	CDD:293791	22/33 (67%)
		WD40 repeat	97..133	CDD:293791	29/35 (83%)
		WD40 repeat	138..205	CDD:293791	45/68 (66%)
		WD40 repeat	212..249	CDD:293791	28/36 (78%)
		WD40 repeat	255..291	CDD:293791	20/35 (57%)
		WD40 repeat	299..352	CDD:293791	30/53 (57%)
		Coatomer_WDAD_alpha	327..773	CDD:438573	201/452 (44%)
		WD40 repeat	327..340	CDD:438573	7/13 (54%)
		WD40 repeat	365..414	CDD:438573	15/51 (29%)
		WD40 repeat	417..439	CDD:438573	13/22 (59%)
		WD40 repeat	458..487	CDD:438573	9/28 (32%)
		WD40 repeat	490..522	CDD:438573	15/31 (48%)
		WD40 repeat	538..564	CDD:438573	12/25 (48%)
		WD40 repeat	566..591	CDD:438573	9/24 (38%)
		COPI_C	815..1228	CDD:462050	129/421 (31%)
cop1	NP_595279.1	WD40	17..325	CDD:238121	219/307 (71%)
		WD40 repeat	17..51	CDD:293791	23/33 (70%)
		WD40 repeat	57..93	CDD:293791	24/35 (69%)
		WD40 repeat	98..134	CDD:293791	29/35 (83%)
		WD40 repeat	141..209	CDD:293791	44/67 (66%)
		WD40 repeat	216..248	CDD:293791	23/31 (74%)
		WD40 repeat	259..285	CDD:293791	17/25 (68%)
		WD40 repeat	303..369	CDD:293791	32/65 (49%)
		Coatomer_WDAD_alpha	331..781	CDD:438573	201/452 (44%)
		WD40 repeat	331..344	CDD:438573	6/12 (50%)
		WD40 repeat	373..419	CDD:438573	14/48 (29%)
		WD40 repeat	375..398	CDD:293791	9/25 (36%)
		WD40 repeat	422..445	CDD:438573	13/22 (59%)
		WD40 repeat	424..455	CDD:293791	17/30 (57%)
		WD40 repeat	463..491	CDD:293791	9/27 (33%)
		WD40 repeat	466..495	CDD:438573	9/28 (32%)
		WD40 repeat	498..530	CDD:438573	15/31 (48%)
		WD40 repeat	546..572	CDD:438573	12/25 (48%)
		WD40 repeat	574..599	CDD:438573	9/24 (38%)
		COPI_C	859..1204	CDD:462050	120/369 (33%)