DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alphaCOP and Y41C4A.32

DIOPT Version :9

Sequence 1:	NP_477395.1	Gene:	alphaCOP / 38199	FlyBaseID:	FBgn0025725	Length:	1234	Species:	Drosophila melanogaster
Sequence 2:	NP_499518.2	Gene:	Y41C4A.32 / 189814	WormBaseID:	WBGene00270321	Length:	291	Species:	Caenorhabditis elegans

Alignment Length:	328	Identity:	96/328 - (29%)
Similarity:	163/328 - (49%)	Gaps:	52/328 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NFESKSARVKGLSFHPKRPWILVSLHSGVIQLWDYRMHTLLEKFDEHDGPVRGVAFHQQMPLFVS 68
            ||.|.|.|||.:.||.::||||.:||:|.:|:|:|...||::..:..:...|...|..:.....:
Worm     7 NFVSHSDRVKSVDFHSEKPWILTALHTGNVQIWNYDTKTLVKAMEVSEKSTRAAKFIHRKNWIAT 71

  Fly    69 GGDDYKIKVWNYKQRRCIFTLLAHLDYVRTVAFHHEYPWILSASDDQTIRIWNWQSR-NCICVLT 132
            ..||.:|::::.:....|....||.|::|::..|...|:::|||||:.||:|:|::. .......
Worm    72 ASDDQQIRIFDAETFSLINEFTAHSDFIRSLTVHPTLPYLISASDDRKIRVWDWENEWRMEQEFQ 136

  Fly   133 GHNHYVMCAQFHPTE-DQIVSASLDQTVRVWDISGLRKKNVAPGPGGLDDHLKGHPGATDLFGQA 196
            .|.||:|....:|.: :..||.|||:|::||.:                             |:.
Worm   137 EHAHYIMQIAVNPEDPEMFVSGSLDKTLKVWKL-----------------------------GEQ 172

  Fly   197 DAVVKHVLEGHDRGVNWASFHPTLPLIVSGADDRLVKLWRMNEYKAWEVDTCR-GHYNNVSSVLF 260
            :::.  .||||::|||...| .|...||||:||..:.:|.:...|.  ::|.: .|.|||:.|.
Worm   173 ESIC--TLEGHEKGVNCVEF-LTGGRIVSGSDDCSICVWDIQTQKC--IETLKNAHKNNVTFVT- 231

  Fly   261 HPRQDLILSNGEDRSIRVWDMTKRQCLFTFRRDNE------RFWILTAHPTLNLFAAGHDGGMVV 319
             |.:..|:|..||.::::|:..      ||..:.|      |.|.:.|..: :..|.|.|.|.|.
Worm   232 -PFKTWIISGAEDSTVKIWNSQ------TFSLEKELNFEKGRAWCVAAGKS-DAIAVGFDSGAVT 288

  Fly   320 FKL 322
            .::
Worm   289 VEI 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaCOP	NP_477395.1	WD40	<2..320	CDD:225201	96/324 (30%)
		WD40	5..321	CDD:238121	95/324 (29%)
		WD40 repeat	15..49	CDD:293791	14/33 (42%)
		WD40 repeat	57..91	CDD:293791	5/33 (15%)
		WD40 repeat	97..133	CDD:293791	12/36 (33%)
		WD40 repeat	138..205	CDD:293791	11/67 (16%)
		WD40 repeat	212..249	CDD:293791	12/36 (33%)
		WD40 repeat	255..291	CDD:293791	9/35 (26%)
		WD40 repeat	299..352	CDD:293791	6/24 (25%)
		Coatomer_WDAD	354..765	CDD:281977
		COPI_C	815..1228	CDD:284395
Y41C4A.32	NP_499518.2	WD40	8..271	CDD:238121	89/304 (29%)
		WD40 repeat	17..52	CDD:293791	14/34 (41%)
		WD40 repeat	58..94	CDD:293791	6/35 (17%)
		WD40 repeat	99..136	CDD:293791	12/36 (33%)
		WD40 repeat	143..179	CDD:293791	11/66 (17%)
		WD40 repeat	185..220	CDD:293791	13/37 (35%)
		WD40 repeat	224..251	CDD:293791	10/28 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122926at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920