DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alphaCOP and copb-2

DIOPT Version :9

Sequence 1:	NP_477395.1	Gene:	alphaCOP / 38199	FlyBaseID:	FBgn0025725	Length:	1234	Species:	Drosophila melanogaster
Sequence 2:	NP_501671.1	Gene:	copb-2 / 177779	WormBaseID:	WBGene00009542	Length:	1000	Species:	Caenorhabditis elegans

Alignment Length:	845	Identity:	224/845 - (26%)
Similarity:	382/845 - (45%)	Gaps:	105/845 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SKSARVKGLSFHPKRPWILVSLHSGVIQLWDYRMHTLLEKFDEHDGPVRGVAFHQQMPLFVSGGD 71
            ::|.|||.:..||...|:|.:|::|.:.:|:|...||::.|:..|.|||...|..:....|:|.|
Worm    13 ARSDRVKCVDLHPVETWLLAALYNGNVHIWNYETQTLVKSFEVCDVPVRAAKFVPRKSWVVTGSD 77

  Fly    72 DYKIKVWNYKQRRCIFTLLAHLDYVRTVAFHHEYPWILSASDDQTIRIWNWQSRNCI-CVLTGHN 135
            |..|:|:||.....:....||.||:|::..|...|:::|:|||..:::|:|.::..: ....||.
Worm    78 DMHIRVFNYNTLERVHQFEAHSDYLRSLVVHPTLPYVISSSDDMLVKMWDWDNKWAMKQSFEGHT 142

  Fly   136 HYVMCAQFHPTEDQ-IVSASLDQTVRVWDISGLRKKNVAPGPGGLDDHLKGHPGATDLFGQADAV 199
            ||||....:|.::. ..:||||:||:||.                             ||  ..|
Worm   143 HYVMQIAINPKDNNTFATASLDKTVKVWQ-----------------------------FG--SNV 176

  Fly   200 VKHVLEGHDRGVNWASFH--PTLPLIVSGADDRLVKLWRMNEYKAWEVDTCRGHYNNVSSVLFHP 262
            ....||||::|||...::  ...|.|:|||||.|||:|.......  |.|..||..|||||.|||
Worm   177 PNFTLEGHEKGVNCVDYYHGGEKPYIISGADDHLVKIWDYQNKTC--VQTLDGHAQNVSSVCFHP 239

  Fly   263 RQDLILSNGEDRSIRVWDMTKRQCLFTFRRDNERFWILTAHPTLNLFAAGHDGGMVVFKLERERP 327
            ...||::..||.::|:|.....:...|.....||.|.:.|....|..|.|:|.|.|..||.||.|
Worm   240 ELPLIITGSEDSTVRLWHANTYRLETTLNYGLERVWCIQAQKGANTIAIGYDEGSVTLKLGREEP 304

  Fly   328 AYAV--HGNILYYVKERFLRKLDFTT--TKDTVVMQ---LRP------GKSPVYSMSYNPALNA- 378
            |.::  .|.|| :.|...:::.:..|  |:::..:|   ..|      |.|.:|..:...:.|.
Worm   305 AVSMDSSGKIL-WAKHSEIQQANLKTISTEESEAIQDGERLPLSVKDLGSSEIYPQTLAHSSNGR 368

  Fly   379 -VLICTRTNNLENSTYDLCQIPKDTESQSESDSKRSSGITAIW-VARNRFAVLDRNQQLVI-KNF 440
             |:.|   .:.|...|....:......|         |:..:| |..|.|||.:....:.| |||
Worm   369 FVVAC---GDGEYIVYTAMALRNKDFGQ---------GLEFVWAVDPNMFAVRESATNVKIKKNF 421

  Fly   441 KNEVTKKLPTFCEEIFYAGTGMLLIRDPEFVTLYEVQRLVSVGSIKLAKCRYVVWSPDMSLVALL 505
            |:..:.:.....|.|  :|..:|.:|....:..::.:..|.|..|::.. :.:.||.:..:||:.
Worm   422 KDHKSIRSDMVLEGI--SGGPLLALRSNNSLCFFDWESAVLVRRIEITS-KSIYWSDNGEMVAIC 483

  Fly   506 CKHSVTICDRRLQYLCTVQENC--------------------RVKSGAWDESGVFIYTTS-NHIK 549
            ...|..:    |:|......|.                    .||:|.| ....||:||: |.|.
Worm   484 GDDSFYV----LKYSAEAVANATEVTEDGIEDAFEVIGEQAEAVKTGFW-IGDCFIFTTALNRIN 543

  Fly   550 YAITNGDHGIIRTLDLPIYLT--RVKGNQVFCLDRECRTRVLHIDPTEYKFKLALIQRKY---DE 609
            |.: .|:...|..:|.|:||.  ..|.::|:.:|::.......:..:..:::.|:::|.:   |:
Worm   544 YYV-GGEIVTIAHVDRPLYLLGYMAKESRVYAVDKDLNVISYKLLLSVLEYQTAVMRRDFDTADK 607

  Fly   610 VLHMVRNARLVGQSIIAYLQQKGYPEVALHFVKDEKTRFGLALECGNIEIALEAAKALDDKDCWD 674
            ||..:...:..  .:..:|:::|:.:.||...:|...:|.|::..|:::.|.:.|...|.::.|.
Worm   608 VLTTIPKEQRT--RVAHFLEKQGFKKQALAVSQDPDHKFDLSVALGDLKTAYDLALQSDSEEKWK 670

  Fly   675 RLGQSALLQGNHQVVEMCYQRTKNFDKLSFLYLITGNLEKLKKMNKIAEIRKDVSAQYQGALLLG 739
            .|..:|.|:....:...|..|.::|..|..|....|:...|:|:...:...:..:..:..:||||
Worm   671 ALSNAATLKSELLLAGECLGRARDFGGLMLLATCAGSAPLLQKLADDSAAAESHNISFLSSLLLG 735

  Fly   740 DVKERVNILKNCGQLSLAYLTAATHGFDELTESLG-ESITSQGNSLPEVNPNAQLLQPPVPIQQL 803
            |:...::.|.:.|:|..|...|.||....::..|. ....:.|:|........:.|..||..:.|
Worm   736 DIDACLDKLISTGRLPEAAFLARTHAPSRVSSILELWKAKASGHSEKSSRKIGESLADPVKYENL 800

Fly 804 803
Worm 801 800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaCOP	NP_477395.1	WD40	<2..320	CDD:225201	106/316 (34%)
		WD40	5..321	CDD:238121	106/317 (33%)
		WD40 repeat	15..49	CDD:293791	11/33 (33%)
		WD40 repeat	57..91	CDD:293791	9/33 (27%)
		WD40 repeat	97..133	CDD:293791	9/36 (25%)
		WD40 repeat	138..205	CDD:293791	14/67 (21%)
		WD40 repeat	212..249	CDD:293791	14/38 (37%)
		WD40 repeat	255..291	CDD:293791	14/35 (40%)
		WD40 repeat	299..352	CDD:293791	18/56 (32%)
		Coatomer_WDAD	354..765	CDD:281977	98/449 (22%)
		COPI_C	815..1228	CDD:284395
copb-2	NP_501671.1	WD40	<8..297	CDD:225201	106/316 (34%)
		WD40	15..295	CDD:238121	105/312 (34%)
		WD40 repeat	19..55	CDD:293791	12/35 (34%)
		WD40 repeat	62..97	CDD:293791	9/34 (26%)
		WD40 repeat	103..140	CDD:293791	9/36 (25%)
		WD40 repeat	145..182	CDD:293791	14/67 (21%)
		WD40 repeat	189..226	CDD:293791	14/38 (37%)
		WD40 repeat	232..268	CDD:293791	14/35 (40%)
		Coatomer_WDAD	320..762	CDD:281977	101/464 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122926at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920