DRSC/TRiP Functional Genomics Resources

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Protein Alignment alphaCOP and copa-1

DIOPT Version :10

Sequence 1:NP_477395.1 Gene:alphaCOP / 38199 FlyBaseID:FBgn0025725 Length:1234 Species:Drosophila melanogaster
Sequence 2:NP_491069.1 Gene:copa-1 / 171860 WormBaseID:WBGene00022119 Length:1232 Species:Caenorhabditis elegans


Alignment Length:1253 Identity:707/1253 - (56%)
Similarity:918/1253 - (73%) Gaps:45/1253 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MLTNFESKSARVKGLSFHPKRPWILVSLHSGVIQLWDYRMHTLLEKFDEHDGPVRGVAFHQQMPL 65
            :|..||||||||||:||||.|||:|.||||||||||||||..||||||||||||||:.||...|:
 Worm     3 LLIKFESKSARVKGISFHPTRPWVLTSLHSGVIQLWDYRMCVLLEKFDEHDGPVRGICFHHDQPI 67

  Fly    66 FVSGGDDYKIKVWNYKQRRCIFTLLAHLDYVRTVAFHHEYPWILSASDDQTIRIWNWQSRNCICV 130
            |||||||||||||||||:|||||||.||||:||..|||:||||:|||||||:|||||||||.|.:
 Worm    68 FVSGGDDYKIKVWNYKQKRCIFTLLGHLDYIRTTFFHHKYPWIISASDDQTVRIWNWQSRNSIAI 132

  Fly   131 LTGHNHYVMCAQFHPTEDQIVSASLDQTVRVWDISGLRKKNVAPGPGGLDDHLKGHPGATDLFGQ 195
            ||||||||||||||||||.:.|||||||||||||||||||.: || ||......|...| :||||
 Worm   133 LTGHNHYVMCAQFHPTEDLVASASLDQTVRVWDISGLRKKQM-PG-GGAPSRPTGGQQA-ELFGQ 194

  Fly   196 ADAVVKHVLEGHDRGVNWASFHPTLPLIVSGADDRLVKLWRMNEYKAWEVDTCRGHYNNVSSVLF 260
            .|||||||||||||||||.:||.|.|::|||:|||.||:||.||.||||:|:|||||||||||:|
 Worm   195 PDAVVKHVLEGHDRGVNWVAFHHTNPILVSGSDDRQVKIWRYNETKAWELDSCRGHYNNVSSVIF 259

  Fly   261 HPRQDLILSNGEDRSIRVWDMTKRQCLFTFRRDNERFWILTAHPTLNLFAAGHDGGMVVFKLERE 325
            ||..||||||.||:|||||||.||..|..||.:|||||:|.|||:||:||||||.||||||::||
 Worm   260 HPNADLILSNSEDKSIRVWDMQKRTSLHVFRHENERFWVLAAHPSLNMFAAGHDNGMVVFKIQRE 324

  Fly   326 RPAYAVHGNILYYVKERFLRKLDFTTTKDTVVMQLR---PGKSPVYSMSYNPALNAVLICTRTNN 387
            ||||.|..|:::|||.:.:||||.||.||..:.:||   |...|.||:|:|||....|:.:||:|
 Worm   325 RPAYCVSDNLVFYVKGQQIRKLDLTTNKDVALCKLRYPQPFMQPYYSLSFNPAEGTFLLTSRTHN 389

  Fly   388 LENSTYDLCQIPKDTESQSESDSKRSSGITAIWVARNRFAVLDRNQQLVIKNFKNEVTKKLP--- 449
            .:...::|.::..:::..:|:...:|:||.|:|||||||||||:.|.:.:::..|:..:||.   
 Worm   390 KDLCAFELYKVASNSDGTTEAACVKSTGINALWVARNRFAVLDKAQNVSLRDLTNKELRKLENIN 454

  Fly   450 TFCEEIFYAGTGMLLIRDPEFVTLYEVQRLVSVGSIKLAKCRYVVWSPDMSLVALLCKHSVTICD 514
            |..::||||||||||:|:.:.:.|::||:.:...|:|::|.|||:||..|...|||.||::|:.:
 Worm   455 TAVDDIFYAGTGMLLLRNDDGLQLFDVQQKIVTASVKVSKVRYVIWSKSMEFAALLSKHTLTLVN 519

  Fly   515 RRLQYLCTVQENCRVKSGAWDESGVFIYTTSNHIKYAITNGDHGIIRTLDLPIYLTRVKGNQVFC 579
            |:|:.|||.||:.||||||||:..||:|||||||||||.:||.||:||||||:|:..::||.::|
 Worm   520 RKLEILCTQQESTRVKSGAWDDDSVFLYTTSNHIKYAINSGDCGIVRTLDLPLYILAIRGNVLYC 584

  Fly   580 LDRECRTRVLHIDPTEYKFKLALIQRKYDEVLHMVRNARLVGQSIIAYLQQKGYPEVALHFVKDE 644
            |:|:.....:.||.::||||||||.::.|||::|||:|.|||||||.||::|||||:||||||||
 Worm   585 LNRDATPVEVPIDNSDYKFKLALINKRIDEVVNMVRSANLVGQSIIGYLEKKGYPEIALHFVKDE 649

  Fly   645 KTRFGLALECGNIEIALEAAKALDDKDCWDRLGQSALLQGNHQVVEMCYQRTKNFDKLSFLYLIT 709
            |||||||:||||:||||||||.||:...|:.||::||||||||:|||.|||||||:||||||.:|
 Worm   650 KTRFGLAIECGNLEIALEAAKKLDEPAVWEALGETALLQGNHQIVEMSYQRTKNFEKLSFLYFVT 714

  Fly   710 GNLEKLKKMNKIAEIRKDVSAQYQGALLLGDVKERVNILKNCGQLSLAYLTAATHGFDELTESLG 774
            ||.:||.||.|||:.|.|....:|.||..|||:|||.:|:||||.|||||.|||||:....|.|.
 Worm   715 GNTDKLVKMMKIAQARNDAHGHFQTALYTGDVEERVKVLRNCGQTSLAYLAAATHGYSAEAEELK 779

  Fly   775 ESITSQGNSLPEVNPNAQLLQPPVPIQQLETNWPLLSVSKGFFEGAMVTRAGSSATARQALNIN- 838
            ..:.|:...:|.|:|||:||.||.|:.:||.|||||:.::|.|:..::...|.||..    |:. 
 Worm   780 AELESRQQPIPPVDPNARLLVPPPPVARLEENWPLLASARGTFDAQLLGLGGQSAPT----NVGG 840

  Fly   839 -----ADAALLDEHNG--GGDGWGADADLGLDEDGDDEMHDALSNDGDGGAGGEEGAGWDVGDDD 896
                 |..|::|:.:|  |.:.||.|..| :.|||:.::     ::|:|...|:|..|||| |||
 Worm   841 VKPAAAAFAVMDDDDGDVGNEAWGDDEYL-VGEDGELDV-----DEGEGPVDGDEEGGWDV-DDD 898

  Fly   897 LVVPEELASKIKASALDSNYYAAPNKGLSPAQQWANNSPLVLDHVKAGSFETAFRLLHDQLGVVN 961
            |.:|:....:    ..|.:....||...:.:.:|.|.|.|..|||.||||.||.:||||.:|||.
 Worm   899 LALPDVTDDQ----GGDDDEEVVPNPAPAVSSEWPNVSRLAADHVAAGSFGTAIKLLHDTIGVVE 959

  Fly   962 FQPFKTLFLQNYACSRTSY-------TANPNLQSLSGYPLRNYSETNIKLQRPAVGIKLNDLVAR 1019
            ..|||.:|::.||.||.|:       .|.|    :|.:|:||:.|.  |...|....||:.|..:
 Worm   960 AAPFKDVFVKAYAASRLSHRGWGGLGPAGP----VSIHPVRNFQED--KNHLPVAAFKLSQLAKK 1018

  Fly  1020 LQAGYQLTTSGKFSEAVEKFHSILISIPLLVVDTKLDAAEAQQLLRICAEYIVGLKMETVRKGMP 1084
            ||..||:||:|||.:||||...||:|:||:||.:|.:.|||:||:.|..||:..|.:||.||.:|
 Worm  1019 LQKAYQMTTNGKFGDAVEKLREILLSVPLIVVSSKQEVAEAEQLITITREYLAALLLETYRKDLP 1083

  Fly  1085 KSTLEEQKRLCEMAAYFTHCKLQPVHQILTLRTALNMFFKLKNYKTAASFARRLLELAPRPDVAQ 1149
            |:.||:.||..|:||||||.:|||:|:|||||:|:|.|||:|..||.||..:|||||||:|:||.
 Worm  1084 KTNLEDAKRNAELAAYFTHFELQPMHRILTLRSAINTFFKMKQMKTCASLCKRLLELAPKPEVAA 1148

  Fly  1150 QVRKILQACEVNPVDEHQLQYEEFNPFTICGISWKPLYRGKPEVTCPFCSSSFDPQFKGNLCTVC 1214
            |:||:|.|.|.:..|.|||.|:|.|||.:|...:.|||||:|...||:|.:|:....:|.:|.||
 Worm  1149 QIRKVLTAAEKDNTDAHQLTYDEHNPFVVCSRQFVPLYRGRPLCKCPYCGASYSEGLEGEVCNVC 1213

  Fly  1215 EVSQIGKDSIGLRISNLQ 1232
            :|:::||:.:|||||.|:
 Worm  1214 QVAEVGKNVLGLRISTLK 1231

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alphaCOPNP_477395.1 WD40 5..321 CDD:238121 243/315 (77%)
WD40 repeat 15..49 CDD:293791 27/33 (82%)
WD40 repeat 57..91 CDD:293791 26/33 (79%)
WD40 repeat 97..133 CDD:293791 27/35 (77%)
WD40 repeat 138..205 CDD:293791 47/66 (71%)
WD40 repeat 212..249 CDD:293791 23/36 (64%)
WD40 repeat 255..291 CDD:293791 25/35 (71%)
WD40 repeat 299..352 CDD:293791 34/52 (65%)
Coatomer_WDAD_alpha 327..773 CDD:438573 249/451 (55%)
WD40 repeat 327..340 CDD:438573 6/12 (50%)
WD40 repeat 365..414 CDD:438573 13/48 (27%)
WD40 repeat 417..439 CDD:438573 13/21 (62%)
WD40 repeat 458..487 CDD:438573 12/28 (43%)
WD40 repeat 490..522 CDD:438573 15/31 (48%)
WD40 repeat 538..564 CDD:438573 19/25 (76%)
WD40 repeat 566..591 CDD:438573 7/24 (29%)
COPI_C 815..1228 CDD:462050 186/427 (44%)
copa-1NP_491069.1 WD40 7..317 CDD:238121 240/312 (77%)
WD40 repeat 17..51 CDD:293791 27/33 (82%)
WD40 repeat 57..93 CDD:293791 28/35 (80%)
WD40 repeat 98..134 CDD:293791 26/35 (74%)
WD40 repeat 141..204 CDD:293791 46/65 (71%)
WD40 repeat 210..243 CDD:293791 21/32 (66%)
WD40 repeat 254..288 CDD:293791 25/33 (76%)
Coatomer_WDAD_alpha 326..770 CDD:438573 246/443 (56%)
WD40 repeat 326..339 CDD:438573 6/12 (50%)
WD40 repeat 367..416 CDD:438573 13/48 (27%)
WD40 repeat 419..441 CDD:438573 13/21 (62%)
WD40 repeat 463..492 CDD:438573 12/28 (43%)
WD40 repeat 495..527 CDD:438573 15/31 (48%)
WD40 repeat 543..569 CDD:438573 19/25 (76%)
WD40 repeat 571..596 CDD:438573 7/24 (29%)
COPI_C 820..1227 CDD:462050 186/427 (44%)

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