DRSC/TRiP Functional Genomics Resources

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Protein Alignment alphaCOP and copa-1

DIOPT Version :9

Sequence 1:NP_477395.1 Gene:alphaCOP / 38199 FlyBaseID:FBgn0025725 Length:1234 Species:Drosophila melanogaster
Sequence 2:NP_491069.1 Gene:copa-1 / 171860 WormBaseID:WBGene00022119 Length:1232 Species:Caenorhabditis elegans


Alignment Length:1253 Identity:707/1253 - (56%)
Similarity:918/1253 - (73%) Gaps:45/1253 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MLTNFESKSARVKGLSFHPKRPWILVSLHSGVIQLWDYRMHTLLEKFDEHDGPVRGVAFHQQMPL 65
            :|..||||||||||:||||.|||:|.||||||||||||||..||||||||||||||:.||...|:
 Worm     3 LLIKFESKSARVKGISFHPTRPWVLTSLHSGVIQLWDYRMCVLLEKFDEHDGPVRGICFHHDQPI 67

  Fly    66 FVSGGDDYKIKVWNYKQRRCIFTLLAHLDYVRTVAFHHEYPWILSASDDQTIRIWNWQSRNCICV 130
            |||||||||||||||||:|||||||.||||:||..|||:||||:|||||||:|||||||||.|.:
 Worm    68 FVSGGDDYKIKVWNYKQKRCIFTLLGHLDYIRTTFFHHKYPWIISASDDQTVRIWNWQSRNSIAI 132

  Fly   131 LTGHNHYVMCAQFHPTEDQIVSASLDQTVRVWDISGLRKKNVAPGPGGLDDHLKGHPGATDLFGQ 195
            ||||||||||||||||||.:.|||||||||||||||||||.: || ||......|...| :||||
 Worm   133 LTGHNHYVMCAQFHPTEDLVASASLDQTVRVWDISGLRKKQM-PG-GGAPSRPTGGQQA-ELFGQ 194

  Fly   196 ADAVVKHVLEGHDRGVNWASFHPTLPLIVSGADDRLVKLWRMNEYKAWEVDTCRGHYNNVSSVLF 260
            .|||||||||||||||||.:||.|.|::|||:|||.||:||.||.||||:|:|||||||||||:|
 Worm   195 PDAVVKHVLEGHDRGVNWVAFHHTNPILVSGSDDRQVKIWRYNETKAWELDSCRGHYNNVSSVIF 259

  Fly   261 HPRQDLILSNGEDRSIRVWDMTKRQCLFTFRRDNERFWILTAHPTLNLFAAGHDGGMVVFKLERE 325
            ||..||||||.||:|||||||.||..|..||.:|||||:|.|||:||:||||||.||||||::||
 Worm   260 HPNADLILSNSEDKSIRVWDMQKRTSLHVFRHENERFWVLAAHPSLNMFAAGHDNGMVVFKIQRE 324

  Fly   326 RPAYAVHGNILYYVKERFLRKLDFTTTKDTVVMQLR---PGKSPVYSMSYNPALNAVLICTRTNN 387
            ||||.|..|:::|||.:.:||||.||.||..:.:||   |...|.||:|:|||....|:.:||:|
 Worm   325 RPAYCVSDNLVFYVKGQQIRKLDLTTNKDVALCKLRYPQPFMQPYYSLSFNPAEGTFLLTSRTHN 389

  Fly   388 LENSTYDLCQIPKDTESQSESDSKRSSGITAIWVARNRFAVLDRNQQLVIKNFKNEVTKKLP--- 449
            .:...::|.::..:::..:|:...:|:||.|:|||||||||||:.|.:.:::..|:..:||.   
 Worm   390 KDLCAFELYKVASNSDGTTEAACVKSTGINALWVARNRFAVLDKAQNVSLRDLTNKELRKLENIN 454

  Fly   450 TFCEEIFYAGTGMLLIRDPEFVTLYEVQRLVSVGSIKLAKCRYVVWSPDMSLVALLCKHSVTICD 514
            |..::||||||||||:|:.:.:.|::||:.:...|:|::|.|||:||..|...|||.||::|:.:
 Worm   455 TAVDDIFYAGTGMLLLRNDDGLQLFDVQQKIVTASVKVSKVRYVIWSKSMEFAALLSKHTLTLVN 519

  Fly   515 RRLQYLCTVQENCRVKSGAWDESGVFIYTTSNHIKYAITNGDHGIIRTLDLPIYLTRVKGNQVFC 579
            |:|:.|||.||:.||||||||:..||:|||||||||||.:||.||:||||||:|:..::||.::|
 Worm   520 RKLEILCTQQESTRVKSGAWDDDSVFLYTTSNHIKYAINSGDCGIVRTLDLPLYILAIRGNVLYC 584

  Fly   580 LDRECRTRVLHIDPTEYKFKLALIQRKYDEVLHMVRNARLVGQSIIAYLQQKGYPEVALHFVKDE 644
            |:|:.....:.||.::||||||||.::.|||::|||:|.|||||||.||::|||||:||||||||
 Worm   585 LNRDATPVEVPIDNSDYKFKLALINKRIDEVVNMVRSANLVGQSIIGYLEKKGYPEIALHFVKDE 649

  Fly   645 KTRFGLALECGNIEIALEAAKALDDKDCWDRLGQSALLQGNHQVVEMCYQRTKNFDKLSFLYLIT 709
            |||||||:||||:||||||||.||:...|:.||::||||||||:|||.|||||||:||||||.:|
 Worm   650 KTRFGLAIECGNLEIALEAAKKLDEPAVWEALGETALLQGNHQIVEMSYQRTKNFEKLSFLYFVT 714

  Fly   710 GNLEKLKKMNKIAEIRKDVSAQYQGALLLGDVKERVNILKNCGQLSLAYLTAATHGFDELTESLG 774
            ||.:||.||.|||:.|.|....:|.||..|||:|||.:|:||||.|||||.|||||:....|.|.
 Worm   715 GNTDKLVKMMKIAQARNDAHGHFQTALYTGDVEERVKVLRNCGQTSLAYLAAATHGYSAEAEELK 779

  Fly   775 ESITSQGNSLPEVNPNAQLLQPPVPIQQLETNWPLLSVSKGFFEGAMVTRAGSSATARQALNIN- 838
            ..:.|:...:|.|:|||:||.||.|:.:||.|||||:.::|.|:..::...|.||..    |:. 
 Worm   780 AELESRQQPIPPVDPNARLLVPPPPVARLEENWPLLASARGTFDAQLLGLGGQSAPT----NVGG 840

  Fly   839 -----ADAALLDEHNG--GGDGWGADADLGLDEDGDDEMHDALSNDGDGGAGGEEGAGWDVGDDD 896
                 |..|::|:.:|  |.:.||.|..| :.|||:.::     ::|:|...|:|..|||| |||
 Worm   841 VKPAAAAFAVMDDDDGDVGNEAWGDDEYL-VGEDGELDV-----DEGEGPVDGDEEGGWDV-DDD 898

  Fly   897 LVVPEELASKIKASALDSNYYAAPNKGLSPAQQWANNSPLVLDHVKAGSFETAFRLLHDQLGVVN 961
            |.:|:....:    ..|.:....||...:.:.:|.|.|.|..|||.||||.||.:||||.:|||.
 Worm   899 LALPDVTDDQ----GGDDDEEVVPNPAPAVSSEWPNVSRLAADHVAAGSFGTAIKLLHDTIGVVE 959

  Fly   962 FQPFKTLFLQNYACSRTSY-------TANPNLQSLSGYPLRNYSETNIKLQRPAVGIKLNDLVAR 1019
            ..|||.:|::.||.||.|:       .|.|    :|.:|:||:.|.  |...|....||:.|..:
 Worm   960 AAPFKDVFVKAYAASRLSHRGWGGLGPAGP----VSIHPVRNFQED--KNHLPVAAFKLSQLAKK 1018

  Fly  1020 LQAGYQLTTSGKFSEAVEKFHSILISIPLLVVDTKLDAAEAQQLLRICAEYIVGLKMETVRKGMP 1084
            ||..||:||:|||.:||||...||:|:||:||.:|.:.|||:||:.|..||:..|.:||.||.:|
 Worm  1019 LQKAYQMTTNGKFGDAVEKLREILLSVPLIVVSSKQEVAEAEQLITITREYLAALLLETYRKDLP 1083

  Fly  1085 KSTLEEQKRLCEMAAYFTHCKLQPVHQILTLRTALNMFFKLKNYKTAASFARRLLELAPRPDVAQ 1149
            |:.||:.||..|:||||||.:|||:|:|||||:|:|.|||:|..||.||..:|||||||:|:||.
 Worm  1084 KTNLEDAKRNAELAAYFTHFELQPMHRILTLRSAINTFFKMKQMKTCASLCKRLLELAPKPEVAA 1148

  Fly  1150 QVRKILQACEVNPVDEHQLQYEEFNPFTICGISWKPLYRGKPEVTCPFCSSSFDPQFKGNLCTVC 1214
            |:||:|.|.|.:..|.|||.|:|.|||.:|...:.|||||:|...||:|.:|:....:|.:|.||
 Worm  1149 QIRKVLTAAEKDNTDAHQLTYDEHNPFVVCSRQFVPLYRGRPLCKCPYCGASYSEGLEGEVCNVC 1213

  Fly  1215 EVSQIGKDSIGLRISNLQ 1232
            :|:::||:.:|||||.|:
 Worm  1214 QVAEVGKNVLGLRISTLK 1231

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alphaCOPNP_477395.1 WD40 <2..320 CDD:225201 243/317 (77%)
WD40 5..321 CDD:238121 243/315 (77%)
WD40 repeat 15..49 CDD:293791 27/33 (82%)
WD40 repeat 57..91 CDD:293791 26/33 (79%)
WD40 repeat 97..133 CDD:293791 27/35 (77%)
WD40 repeat 138..205 CDD:293791 47/66 (71%)
WD40 repeat 212..249 CDD:293791 23/36 (64%)
WD40 repeat 255..291 CDD:293791 25/35 (71%)
WD40 repeat 299..352 CDD:293791 34/52 (65%)
Coatomer_WDAD 354..765 CDD:281977 231/416 (56%)
COPI_C 815..1228 CDD:284395 186/427 (44%)
copa-1NP_491069.1 WD40 7..317 CDD:238121 240/312 (77%)
WD40 14..503 CDD:225201 315/491 (64%)
WD40 repeat 17..51 CDD:293791 27/33 (82%)
WD40 repeat 57..93 CDD:293791 28/35 (80%)
WD40 repeat 98..134 CDD:293791 26/35 (74%)
WD40 repeat 141..204 CDD:293791 46/65 (71%)
WD40 repeat 210..243 CDD:293791 21/32 (66%)
WD40 repeat 254..288 CDD:293791 25/33 (76%)
Coatomer_WDAD 341..770 CDD:281977 238/428 (56%)
COPI_C 820..1227 CDD:284395 186/427 (44%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160167366
Domainoid 1 1.000 483 1.000 Domainoid score I198
eggNOG 1 0.900 - - E1_KOG0292
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H3218
Inparanoid 1 1.050 1438 1.000 Inparanoid score I49
Isobase 1 0.950 - 0 Normalized mean entropy S497
OMA 1 1.010 - - QHG53722
OrthoDB 1 1.010 - - D122926at33208
OrthoFinder 1 1.000 - - FOG0004006
OrthoInspector 1 1.000 - - oto17523
orthoMCL 1 0.900 - - OOG6_101600
Panther 1 1.100 - - LDO PTHR19876
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R225
SonicParanoid 1 1.000 - - X2767
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1817.750

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