Protein Alignment alphaCOP and Copa

DIOPT Version :10

• Sequence 1: NP_477395.1
• Gene: alphaCOP / 38199
• FlyBaseID: FBgn0025725
• Length: 1234
• Species: Drosophila melanogaster
• Sequence 2: XP_036013272.1
• Gene: Copa / 12847
• MGIID: 1334462
• Length: 1233
• Species: Mus musculus
• Alignment Length: 1250
• Identity: 877/1250 - (70%)
• Similarity: 1017/1250 - (81%)
• Gaps: 33/1250 - (2%)

  Fly     1 MLTNFESKSARVKGLSFHPKRPWILVSLHSGVIQLWDYRMHTLLEKFDEHDGPVRGVAFHQQMPL 65
            |||.||:||||||||||||||||||.|||:||||||||||.||::|||||||||||:.||:|.||
Mouse     1 MLTKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPL 65

  Fly    66 FVSGGDDYKIKVWNYKQRRCIFTLLAHLDYVRTVAFHHEYPWILSASDDQTIRIWNWQSRNCICV 130
            ||||||||||||||||.|||:||||.||||:||..||||||||||||||||||:||||||.|:||
Mouse    66 FVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCV 130

  Fly   131 LTGHNHYVMCAQFHPTEDQIVSASLDQTVRVWDISGLRKKNVAPGPGGLDDHLKGHPGATDLFGQ 195
            |||||||||||||||:||.:|||||||||||||||||||||::  ||.::..::|..| .||||.
Mouse   131 LTGHNHYVMCAQFHPSEDLVVSASLDQTVRVWDISGLRKKNLS--PGAVESDVRGITG-VDLFGT 192

  Fly   196 ADAVVKHVLEGHDRGVNWASFHPTLPLIVSGADDRLVKLWRMNEYKAWEVDTCRGHYNNVSSVLF 260
            .||||||||||||||||||:||||:||||||||||.||:|||||.||||||||||||||||..:|
Mouse   193 TDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVF 257

  Fly   261 HPRQDLILSNGEDRSIRVWDMTKRQCLFTFRRDNERFWILTAHPTLNLFAAGHDGGMVVFKLERE 325
            ||||:|||||.||:|||||||:||..:.|||||::|||:|.|||.||||||||||||:|||||||
Mouse   258 HPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLNLFAAGHDGGMIVFKLERE 322

  Fly   326 RPAYAVHGNILYYVKERFLRKLDFTTTKDTVVMQLRPG-KSPVYSMSYNPALNAVLICTRTNNLE 389
            |||||||||:|:|||:||||:|||.::||..|||||.| |.||::||||||.||||:|||.:|||
Mouse   323 RPAYAVHGNMLHYVKDRFLRQLDFNSSKDVAVMQLRSGSKFPVFNMSYNPAENAVLLCTRASNLE 387

  Fly   390 NSTYDLCQIPKDTESQSES--DSKRSSGITAIWVARNRFAVLDRNQQLVIKNFKNEVTKKL--PT 450
            ||||||..||||.:||:..  :.|||||:||:||||||||||||...|:|||.|||:|||:  |.
Mouse   388 NSTYDLYTIPKDADSQNPDAPEGKRSSGLTAVWVARNRFAVLDRMHSLLIKNLKNEITKKIQVPN 452

  Fly   451 FCEEIFYAGTGMLLIRDPEFVTLYEVQRLVSVGSIKLAKCRYVVWSPDMSLVALLCKH------- 508
             |:||||||||.||:||.:.:||::||:..::.|:|::|.:||:||.|||.||||.||
Mouse   453 -CDEIFYAGTGNLLLRDADSITLFDVQQKRTLASVKISKVKYVIWSADMSHVALLAKHEHSCPLP 516

  Fly   509 --SVTICDRRLQYLCTVQENCRVKSGAWDESGVFIYTTSNHIKYAITNGDHGIIRTLDLPIYLTR 571
              ::.||:|:|..||.:.||.||||||||||||||||||||||||:|.||||||||||||||:||
Mouse   517 LTAIVICNRKLDALCNIHENIRVKSGAWDESGVFIYTTSNHIKYAVTTGDHGIIRTLDLPIYVTR 581

  Fly   572 VKGNQVFCLDRECRTRVLHIDPTEYKFKLALIQRKYDEVLHMVRNARLVGQSIIAYLQQKGYPEV 636
            ||||.|:|||||||.|||.|||||:|||||||.|||||||||||||:|||||||||||:||||||
Mouse   582 VKGNNVYCLDRECRPRVLTIDPTEFKFKLALINRKYDEVLHMVRNAKLVGQSIIAYLQKKGYPEV 646

  Fly   637 ALHFVKDEKTRFGLALECGNIEIALEAAKALDDKDCWDRLGQSALLQGNHQVVEMCYQRTKNFDK 701
            ||||||||||||.|||||||||||||||||||||:||::||:.||||||||:|||||||||||||
Mouse   647 ALHFVKDEKTRFSLALECGNIEIALEAAKALDDKNCWEKLGEVALLQGNHQIVEMCYQRTKNFDK 711

  Fly   702 LSFLYLITGNLEKLKKMNKIAEIRKDVSAQYQGALLLGDVKERVNILKNCGQLSLAYLTAATHGF 766
            ||||||||||||||:||.||||||||:|..||.||.||||.|||.|||||||.|||||:|||||.
Mouse   712 LSFLYLITGNLEKLRKMMKIAEIRKDMSGHYQNALYLGDVSERVRILKNCGQKSLAYLSAATHGL 776

  Fly   767 DELTESLGESITSQGNSLPEVNPNAQLLQPPVPIQQLETNWPLLSVSKGFFEGAMVTRAGSSATA 831
            ||..|||.|:...:..::|:::|||:|||||.||..|:||||||:||||||||::.::....|.|
Mouse   777 DEEAESLKETFDPEKETIPDIDPNAKLLQPPAPIMPLDTNWPLLTVSKGFFEGSIASKGKGGALA 841

  Fly   832 RQALNINADAALLDEHNGGGDGWGADADLGLDEDGDDEMHDALSNDGDGGAGGEEGAGWDVGDDD 896
                   ||   :|....|.:|||.||:|.|||||..|..:.|..| ..|.|.|||.|||| ::|
Mouse   842 -------AD---IDIDTVGTEGWGEDAELQLDEDGFVEAPEGLGED-VLGKGQEEGGGWDV-EED 894

  Fly   897 LVVPEEL--ASKIKASALDSNYYAAPNKGLSPAQQWANNSPLVLDHVKAGSFETAFRLLHDQLGV 959
            |.:|.||  .|.:..||.| .::..|.||.||.|.|.|||.|.:||:.|||||||.||||||:||
Mouse   895 LELPPELDVPSGVSGSAED-GFFVPPTKGTSPTQIWCNNSQLPVDHILAGSFETAMRLLHDQVGV 958

  Fly   960 VNFQPFKTLFLQNYACSRTSYTANPNLQSLSGYPLRNYSETNIKLQRPAVGIKLNDLVARLQAGY 1024
            :.|.|:|.||||.||..||:|.|.|.|.|:..||.||:.:..:|...||||:|||||:.|||..|
Mouse   959 IQFGPYKQLFLQTYARGRTTYQALPCLPSMYSYPNRNWKDAGLKNGVPAVGLKLNDLIQRLQLCY 1023

  Fly  1025 QLTTSGKFSEAVEKFHSILISIPLLVVDTKLDAAEAQQLLRICAEYIVGLKMETVRKGMPKSTLE 1089
            ||||.|||.||||||.|||:|:||||||.|.:.||||||:.||.||||||.||..||.:||.||:
Mouse  1024 QLTTVGKFEEAVEKFRSILLSVPLLVVDNKQEIAEAQQLITICREYIVGLCMEIERKKLPKETLD 1088

  Fly  1090 EQKRLCEMAAYFTHCKLQPVHQILTLRTALNMFFKLKNYKTAASFARRLLELAPRPDVAQQVRKI 1154
            :|||:|||||||||..|||||.||.||||||:||||||:||||:||||||||.|:|:||||.|||
Mouse  1089 QQKRICEMAAYFTHSNLQPVHMILVLRTALNLFFKLKNFKTAATFARRLLELGPKPEVAQQTRKI 1153

  Fly  1155 LQACEVNPVDEHQLQYEEFNPFTICGISWKPLYRGKPEVTCPFCSSSFDPQFKGNLCTVCEVSQI 1219
            |.|||.||.|..||.|:..|||.||..|::|:|||||...||...:.:.|:|||.:|.|..|::|
Mouse  1154 LSACEKNPTDACQLNYDMHNPFDICAASYRPIYRGKPVEKCPLSGACYSPEFKGQICRVTTVTEI 1218

  Fly  1220 GKDSIGLRISNLQFR 1234
            |||.||||||.||||
Mouse  1219 GKDVIGLRISPLQFR 1233

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alphaCOP	NP_477395.1	WD40	5..321	CDD:238121	254/315 (81%)
		WD40 repeat	15..49	CDD:293791	28/33 (85%)
		WD40 repeat	57..91	CDD:293791	27/33 (82%)
		WD40 repeat	97..133	CDD:293791	30/35 (86%)
		WD40 repeat	138..205	CDD:293791	46/66 (70%)
		WD40 repeat	212..249	CDD:293791	31/36 (86%)
		WD40 repeat	255..291	CDD:293791	24/35 (69%)
		WD40 repeat	299..352	CDD:293791	43/52 (83%)
		Coatomer_WDAD_alpha	327..773	CDD:438573	341/459 (74%)
		WD40 repeat	327..340	CDD:438573	10/12 (83%)
		WD40 repeat	365..414	CDD:438573	32/50 (64%)
		WD40 repeat	417..439	CDD:438573	16/21 (76%)
		WD40 repeat	458..487	CDD:438573	13/28 (46%)
		WD40 repeat	490..522	CDD:438573	18/40 (45%)
		WD40 repeat	538..564	CDD:438573	23/25 (92%)
		WD40 repeat	566..591	CDD:438573	20/24 (83%)
		COPI_C	815..1228	CDD:462050	241/414 (58%)
Copa	XP_036013272.1	WD40	9..318	CDD:238121	251/311 (81%)
		WD40 repeat	15..49	CDD:293791	28/33 (85%)
		WD40 repeat	55..91	CDD:293791	29/35 (83%)
		WD40 repeat	96..132	CDD:293791	29/35 (83%)
		WD40 repeat	139..202	CDD:293791	45/65 (69%)
		WD40 repeat	208..241	CDD:293791	27/32 (84%)
		WD40 repeat	249..278	CDD:293791	22/28 (79%)
		Coatomer_WDAD_alpha	324..783	CDD:438573	341/459 (74%)
		WD40 repeat	324..337	CDD:438573	10/12 (83%)
		WD40 repeat	363..414	CDD:438573	32/50 (64%)
		WD40 repeat	365..406	CDD:293791	29/40 (73%)
		WD40 repeat	417..439	CDD:438573	16/21 (76%)
		WD40 repeat	459..488	CDD:438573	13/28 (46%)
		WD40 repeat	491..532	CDD:438573	18/40 (45%)
		WD40 repeat	548..574	CDD:438573	23/25 (92%)
		WD40 repeat	576..601	CDD:438573	20/24 (83%)
		COPI_C	825..1227	CDD:462050	241/414 (58%)