DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alphaCOP and copb2

DIOPT Version :9

Sequence 1:	NP_477395.1	Gene:	alphaCOP / 38199	FlyBaseID:	FBgn0025725	Length:	1234	Species:	Drosophila melanogaster
Sequence 2:	NP_001001940.1	Gene:	copb2 / 114454	ZFINID:	ZDB-GENE-010724-7	Length:	934	Species:	Danio rerio

Alignment Length:	901	Identity:	236/901 - (26%)
Similarity:	402/901 - (44%)	Gaps:	129/901 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SKSARVKGLSFHPKRPWILVSLHSGVIQLWDYRMHTLLEKFDEHDGPVRGVAFHQQMPLFVSGGD 71
            ::|.|||.:..||..||:|.||::|.:.:|::...||::.|:..|.|||...|..:....::|.|
Zfish    13 ARSDRVKSVDLHPSEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRASKFVARKNWVITGAD 77

  Fly    72 DYKIKVWNYKQRRCIFTLLAHLDYVRTVAFHHEYPWILSASDDQTIRIWNWQSR-NCICVLTGHN 135
            |.:|:|:||.....:....||.||:|.:|.|...|:||::|||..|::|:|:.: :|..|..||.
Zfish    78 DMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPYILTSSDDMLIKLWDWEKKWSCSQVFEGHT 142

  Fly   136 HYVMCAQFHPTE-DQIVSASLDQTVRVWDISGLRKKNVAPGPGGLDDHLKGHPGATDLFGQADAV 199
            ||||....:|.: :|..|||||:|::||.:.                  ...|..|
Zfish   143 HYVMQIVINPKDNNQFASASLDRTIKVWQLG------------------SSSPNFT--------- 180

  Fly   200 VKHVLEGHDRGVNWASFHP--TLPLIVSGADDRLVKLWRMNEYKAWEVDTCRGHYNNVSSVLFHP 262
                |||||:|||...::.  ..|.::|||||||||:|.......  |.|..||..|||.|.|||
Zfish   181 ----LEGHDKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTC--VQTLEGHAQNVSCVNFHP 239

  Fly   263 RQDLILSNGEDRSIRVWDMTKRQCLFTFRRDNERFWILTAHPTLNLFAAGHDGGMVVFKLERERP 327
            ...:|::..||.::|:|..:..:...|.....||.|.::.....|..|.|:|.|.::.||.||.|
Zfish   240 ELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVSGLRGSNSVALGYDEGSIIIKLGREEP 304

  Fly   328 AYAV--HGNILY----YVKERFLRKLDFTTTKDTVVMQLR---PGKSPVY--SMSYNPALNAVLI 381
            |.::  :|.|::    .:::..|:.:.....||...:.|.   .|...:|  ::.:||....|::
Zfish   305 AMSMDTNGKIIWAKHSEIQQANLKAMGDAEIKDGERLPLAVKDMGSCEIYPQTIQHNPNGRFVVV 369

  Fly   382 C-------TRTNNLENSTYDLCQIPKDTESQSESDSKRSSGITAIWVARNRFAVLDRNQQLVIKN 439
            |       .....|.|.::...|........||...:.||.:..|:                 ||
Zfish   370 CGDGEYIIYTAMALRNKSFGSAQEFVWAHDSSEYAIRESSSVVKIF-----------------KN 417

  Fly   440 FKNEVTKKLPTFCEEIFYAGTGMLLIRDPEFVTLYEVQRLVSVGSIKLAKCRYVVWSPDMSLVAL 504
            ||.:.:.| |.|..|..|.|. :|.:|....:..|:.:....:..|:: :.:::.||....||.:
Zfish   418 FKEKKSFK-PDFGAEGIYGGF-LLGVRSVNGLAFYDWENTELIRRIEI-QPKHIFWSDSGELVCI 479

  Fly   505 LCKHSVTICDRRLQYL----CTVQENCR--------------------VKSGAWDESGVFIYTTS 545
            ..:.|..|    |:||    ...|||..                    ||:|.| ....||||:|
Zfish   480 ATEESFFI----LRYLSEKVAASQENNEGVTEDGIEDAFEVLGEIQEVVKTGLW-VGDCFIYTSS 539

  Fly   546 -NHIKYAITNGDHGIIRTLDLPIYLTRV--KGNQVFCLDRECRTRVLHIDPTEYKFKLALIQRKY 607
             |.:.|.: .|:...|..||..:||...  |.::::..|:|.......:..:..:::.|:::|.:
Zfish   540 VNRLNYFV-GGEIVTIAHLDRTMYLLGYIPKDDRLYLGDKELNIVSYSLLVSVLEYQTAVMRRDF 603

  Fly   608 ---DEVLHMVRNARLVGQSIIAYLQQKGYPEVALHFVKDEKTRFGLALECGNIEIALEAAKALDD 669
               |:||..:...:..  .:..:|:::|:.:.||....|.:.||.|||:.|.::||.:.|...:.
Zfish   604 GMADKVLPTIPKEQRT--RVAHFLEKQGFKQQALAVSTDPEHRFELALQLGELKIAYQLAVEAES 666

  Fly   670 KDCWDRLGQSALLQGNHQVVEMCYQRTKNFDKLSFLYLITGNLEKLKKMNKIAEIRKDVSAQYQG 734
            :..|.:|.:.|:.:....:.:.|....:::..|..|...:||...:.|:.:.||.....:..:..
Zfish   667 EQKWKQLAELAISKCQFGLAQECLHHAQDYGGLLLLATASGNASMVAKLAEGAERDGKNNVAFMT 731

  Fly   735 ALLLGDVKERVNILKNCGQLSLAYLTAATHGFDELTESLGESITSQGNSLPEVNPN-AQLLQPPV 798
            ..|.|.:...:.:|....:|..|...|.|:    |...:...:.....||.:||.. |:.|..|.
Zfish   732 YFLQGKLDNCLELLIKTNRLPEAAFLARTY----LPSQVSRVVKLWRESLSKVNQKAAESLADPT 792

  Fly   799 PIQQLETNWPLLSVSKGFFEGAMVTRAGSSATARQA-----LNINADAALLDEHNG 849
            ..:.|   :|.|   :..|......:..|....|.|     :..|.:..:|:|.:|
Zfish   793 EYENL---FPGL---REAFVAEQYLKETSLGQTRPASDYPLITPNEERNVLEEASG 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaCOP	NP_477395.1	WD40	<2..320	CDD:225201	108/316 (34%)
		WD40	5..321	CDD:238121	108/317 (34%)
		WD40 repeat	15..49	CDD:293791	12/33 (36%)
		WD40 repeat	57..91	CDD:293791	8/33 (24%)
		WD40 repeat	97..133	CDD:293791	14/36 (39%)
		WD40 repeat	138..205	CDD:293791	14/67 (21%)
		WD40 repeat	212..249	CDD:293791	14/38 (37%)
		WD40 repeat	255..291	CDD:293791	12/35 (34%)
		WD40 repeat	299..352	CDD:293791	14/58 (24%)
		Coatomer_WDAD	354..765	CDD:281977	99/452 (22%)
		COPI_C	815..1228	CDD:284395	8/40 (20%)
copb2	NP_001001940.1	WD40	8..297	CDD:238121	108/316 (34%)
		WD40 repeat	19..55	CDD:293791	13/35 (37%)
		WD40	24..428	CDD:225201	136/454 (30%)
		WD40 repeat	103..140	CDD:293791	14/36 (39%)
		WD40 repeat	145..182	CDD:293791	14/67 (21%)
		WD40 repeat	189..226	CDD:293791	14/38 (37%)
		WD40 repeat	232..262	CDD:293791	11/29 (38%)
		Coatomer_WDAD	320..763	CDD:281977	101/474 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122926at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920