DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alphaCOP and copa

DIOPT Version :9

Sequence 1:	NP_477395.1	Gene:	alphaCOP / 38199	FlyBaseID:	FBgn0025725	Length:	1234	Species:	Drosophila melanogaster
Sequence 2:	NP_001121466.1	Gene:	copa / 100158562	XenbaseID:	XB-GENE-989762	Length:	1224	Species:	Xenopus tropicalis

Alignment Length:	1242	Identity:	872/1242 - (70%)
Similarity:	1017/1242 - (81%)	Gaps:	26/1242 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLTNFESKSARVKGLSFHPKRPWILVSLHSGVIQLWDYRMHTLLEKFDEHDGPVRGVAFHQQMPL 65
            |||.||:||||||||||||||||:|.|||:||||||||||.||::|||||||||||:.||:|.||
Frog     1 MLTKFETKSARVKGLSFHPKRPWVLTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPL 65

  Fly    66 FVSGGDDYKIKVWNYKQRRCIFTLLAHLDYVRTVAFHHEYPWILSASDDQTIRIWNWQSRNCICV 130
            ||||||||||||||||.|||:||||.||||:||..|||||||||||||||||||||||||.|:||
Frog    66 FVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRIWNWQSRTCVCV 130

  Fly   131 LTGHNHYVMCAQFHPTEDQIVSASLDQTVRVWDISGLRKKNVAPGPGGLDDHLKGHPGATDLFGQ 195
            |||||||||||||||:||.:|||||||||||||||||||||::  ||.::..::|..| .||||.
Frog   131 LTGHNHYVMCAQFHPSEDLVVSASLDQTVRVWDISGLRKKNLS--PGAVEADVRGISG-VDLFGT 192

  Fly   196 ADAVVKHVLEGHDRGVNWASFHPTLPLIVSGADDRLVKLWRMNEYKAWEVDTCRGHYNNVSSVLF 260
            :||||||||||||||||||:||||:||||||||||.||:|||||.||||||||||||||||..:|
Frog   193 SDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVF 257

  Fly   261 HPRQDLILSNGEDRSIRVWDMTKRQCLFTFRRDNERFWILTAHPTLNLFAAGHDGGMVVFKLERE 325
            ||||:|||||.||:|||||||:||..:.|||||::|||:|.|||.||||||||||||:|||||||
Frog   258 HPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLNLFAAGHDGGMIVFKLERE 322

  Fly   326 RPAYAVHGNILYYVKERFLRKLDFTTTKDTVVMQLRPG-KSPVYSMSYNPALNAVLICTRTNNLE 389
            |||||||||||||||:||||:|||.::||..|||||.| |.||::||||||.|:||:|||.:|||
Frog   323 RPAYAVHGNILYYVKDRFLRQLDFNSSKDVAVMQLRSGSKFPVFNMSYNPAENSVLLCTRASNLE 387

  Fly   390 NSTYDLCQIPKDTESQSES--DSKRSSGITAIWVARNRFAVLDRNQQLVIKNFKNEVTKK--LPT 450
            ||||||..|||||:||:..  :.|||||:||:||||||||||||...::|||.|||:|||  :|.
Frog   388 NSTYDLYTIPKDTDSQNPDAPEGKRSSGLTAVWVARNRFAVLDRMHSILIKNLKNEITKKVQVPN 452

  Fly   451 FCEEIFYAGTGMLLIRDPEFVTLYEVQRLVSVGSIKLAKCRYVVWSPDMSLVALLCKHSVTICDR 515
             |:||||||||.||:||.:.:||::||:..::.|:|::|.:||:||.|||.||||.||::.||:|
Frog   453 -CDEIFYAGTGNLLLRDSDSITLFDVQQKRTLASVKISKVKYVIWSSDMSHVALLAKHAIMICNR 516

  Fly   516 RLQYLCTVQENCRVKSGAWDESGVFIYTTSNHIKYAITNGDHGIIRTLDLPIYLTRVKGNQVFCL 580
            :|:.||.:.||.||||||||||||||||||||||||:|.||||||||||||||:||||||.|:||
Frog   517 KLESLCNIHENIRVKSGAWDESGVFIYTTSNHIKYALTTGDHGIIRTLDLPIYITRVKGNNVYCL 581

  Fly   581 DRECRTRVLHIDPTEYKFKLALIQRKYDEVLHMVRNARLVGQSIIAYLQQKGYPEVALHFVKDEK 645
            |||||.|||.|||||:|||||||.|||||||||||||:|||||||||||:|||||||||||||||
Frog   582 DRECRPRVLTIDPTEFKFKLALINRKYDEVLHMVRNAKLVGQSIIAYLQKKGYPEVALHFVKDEK 646

  Fly   646 TRFGLALECGNIEIALEAAKALDDKDCWDRLGQSALLQGNHQVVEMCYQRTKNFDKLSFLYLITG 710
            |||.|||||||||||||||||||||:||::||:.||||||||:||||||||||||||||||||||
Frog   647 TRFSLALECGNIEIALEAAKALDDKNCWEKLGEVALLQGNHQIVEMCYQRTKNFDKLSFLYLITG 711

  Fly   711 NLEKLKKMNKIAEIRKDVSAQYQGALLLGDVKERVNILKNCGQLSLAYLTAATHGFDELTESLGE 775
            |||||:||.||||||||:|.|||.||.||||.|||.|||||||.|||||||||||.::..|.|.|
Frog   712 NLEKLRKMMKIAEIRKDMSGQYQNALFLGDVDERVRILKNCGQKSLAYLTAATHGINDEEEGLRE 776

  Fly   776 SITSQGNSLPEVNPNAQLLQPPVPIQQLETNWPLLSVSKGFFEGAMVTRAGSSATARQALNINAD 840
            :...:...:|||:|:|:||.||.||..|:||||||::|||||||::..:....|.|       ||
Frog   777 TFDPEKEIIPEVDPDAKLLMPPPPIMPLDTNWPLLTMSKGFFEGSIGNKGKGGALA-------AD 834

  Fly   841 AALLDEHNGGGDGWGADADLGLDEDGDDEMHDALSNDGD--GGAGGEEGAGWDVGDDDLVVPEEL 903
               :|....||:|||.||:|.|||||   ..||..|.||  .|.|.|||.|||| ::||.:|.||
Frog   835 ---IDVDTVGGEGWGEDAELQLDEDG---FVDAGENFGDEVAGKGQEEGGGWDV-EEDLDLPPEL 892

  Fly   904 -ASKIKASALDSNYYAAPNKGLSPAQQWANNSPLVLDHVKAGSFETAFRLLHDQLGVVNFQPFKT 967
             .....:...:..::..|.||.||:|.|.|||.|.:|||.|||||||.||||||:|||:|.|||.
Frog   893 DVPSGPSGTAEDGFFVPPTKGNSPSQTWCNNSQLPVDHVLAGSFETAMRLLHDQVGVVDFGPFKQ 957

  Fly   968 LFLQNYACSRTSYTANPNLQSLSGYPLRNYSETNIKLQRPAVGIKLNDLVARLQAGYQLTTSGKF 1032
            .||..::..|::|.|.|.|.|:.|||.||:.:..:|...||||:|||||:.|||..|||||||||
Frog   958 HFLHTFSRGRSTYQALPGLPSMYGYPQRNWKDAGLKNGLPAVGLKLNDLIQRLQLCYQLTTSGKF 1022

  Fly  1033 SEAVEKFHSILISIPLLVVDTKLDAAEAQQLLRICAEYIVGLKMETVRKGMPKSTLEEQKRLCEM 1097
            .||||||..||:|:||||||.|.:.:|||||:.||.||||||.||..||.:||.|||:|||:|||
Frog  1023 EEAVEKFRLILLSVPLLVVDNKQEISEAQQLITICREYIVGLTMEIDRKKLPKDTLEQQKRICEM 1087

  Fly  1098 AAYFTHCKLQPVHQILTLRTALNMFFKLKNYKTAASFARRLLELAPRPDVAQQVRKILQACEVNP 1162
            ||||||..|||||.||.||||:|:||||||:||||:||||||||.|:|:||||.||||.|||.|.
Frog  1088 AAYFTHSNLQPVHMILVLRTAVNLFFKLKNFKTAAAFARRLLELGPKPEVAQQTRKILSACEKNL 1152

  Fly  1163 VDEHQLQYEEFNPFTICGISWKPLYRGKPEVTCPFCSSSFDPQFKGNLCTVCEVSQIGKDSIGLR 1227
            .|.:||.|:..|||.||..|::|:|||||...||...:.:.|:|||.:|.|..|::||||.||||
Frog  1153 TDTYQLNYDMHNPFDICAASYRPIYRGKPVEKCPLSGACYSPEFKGQICRVTTVTEIGKDVIGLR 1217

  Fly  1228 ISNLQFR 1234
            ||.||||
Frog  1218 ISPLQFR 1224

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaCOP	NP_477395.1	WD40	<2..320	CDD:225201	255/317 (80%)
		WD40	5..321	CDD:238121	254/315 (81%)
		WD40 repeat	15..49	CDD:293791	27/33 (82%)
		WD40 repeat	57..91	CDD:293791	27/33 (82%)
		WD40 repeat	97..133	CDD:293791	31/35 (89%)
		WD40 repeat	138..205	CDD:293791	46/66 (70%)
		WD40 repeat	212..249	CDD:293791	31/36 (86%)
		WD40 repeat	255..291	CDD:293791	24/35 (69%)
		WD40 repeat	299..352	CDD:293791	45/52 (87%)
		Coatomer_WDAD	354..765	CDD:281977	317/415 (76%)
		COPI_C	815..1228	CDD:284395	237/415 (57%)
copa	NP_001121466.1	WD40	9..318	CDD:238121	251/311 (81%)
		WD40 repeat	15..49	CDD:293791	27/33 (82%)
		WD40 repeat	55..91	CDD:293791	29/35 (83%)
		WD40 repeat	96..132	CDD:293791	30/35 (86%)
		WD40 repeat	139..202	CDD:293791	45/65 (69%)
		WD40 repeat	208..241	CDD:293791	27/32 (84%)
		WD40 repeat	249..278	CDD:293791	22/28 (79%)
		WD40 repeat	327..358	CDD:293791	23/30 (77%)
		Coatomer_WDAD	338..767	CDD:367786	326/429 (76%)
		COPI_C	816..1218	CDD:369149	237/415 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	636	1.000	Domainoid score	I170
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3218
Inparanoid	1	1.050	1664	1.000	Inparanoid score	I73
OMA	1	1.010	-	-		QHG53722
OrthoDB	1	1.010	-	-		D122926at33208
OrthoFinder	1	1.000	-	-		FOG0004006
OrthoInspector	1	1.000	-	-		oto104369
Panther	1	1.100	-	-	LDO	PTHR19876
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2767
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080