Protein Alignment Mettl2 and METTL2B

DIOPT Version :10

• Sequence 1: NP_647636.3
• Gene: Mettl2 / 38197
• FlyBaseID: FBgn0035247
• Length: 325
• Species: Drosophila melanogaster
• Sequence 2: NP_060866.2
• Gene: METTL2B / 55798
• HGNCID: 18272
• Length: 378
• Species: Homo sapiens
• Alignment Length: 368
• Identity: 161/368 - (43%)
• Similarity: 213/368 - (57%)
• Gaps: 77/368 - (20%)

  Fly    35 PSGA-----------GSRVLTDAREVFEFNAWDHVQWDEEQELAAKAAVAKNSTSKMEAEQKERF 88
            |.||           |||.|:|...||..||||:|:|.|||..||:..|.:||..::..|::..:
Human     6 PEGAPAILADKRQQFGSRFLSDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQRVCQEKQVDY 70

  Fly    89 QTDAPKFWDSFYGIHDNRFFKDRHWLFTEFPELAP-----------LAADSAVLQPRS------- 135
            :.:|.|:|:.||.||:|.|||||||||||||||||           |...|.|.:.|:
Human    71 EINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENKSEVCECRNNEDGPGL 135

  Fly   136 ------------------------------------------------IFELGCGVGNTILPLLQ 152
                                                            |.|:|||||||:.|:||
Human   136 IMEEQHKCSSKSLEHKTQTPPVEENVTQKISDLEICADEFPGSSATYRILEVGCGVGNTVFPILQ 200

  Fly   153 YSSEPQLKVFGCDFSARAIEILRSQRQFDEKRCEVFVMDATLDHWQVPFEENSQDIIVMIFVLSA 217
            .:::|.|.|:.||||:.|||::::..::|..||..||.|...:....|..:.|.|||::||||||
Human   201 TNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDLCDEEKSYPVPKGSLDIIILIFVLSA 265

  Fly   218 IEPKKMQRVLDNCYRYLRPGGLLLFRDYGRYDLAQLRFKSGKCMEDNFYVRGDGTMVYFFTEEEL 282
            :.|.|||:.::...|.|:|||::|.|||||||:||||||.|:|:..|||||||||.|||||:|||
Human   266 VVPDKMQKAINRLSRLLKPGGMVLLRDYGRYDMAQLRFKKGQCLSGNFYVRGDGTRVYFFTQEEL 330

  Fly   283 RGMMTQAGLQEEQLIVDRRLQVNRCRGLKMYRVWIQTKFRKPL 325
            ..:.|.|||::.|.:|||||||||.:.|.|||||||.|:.|||
Human   331 DTLFTTAGLEKVQNLVDRRLQVNRGKQLTMYRVWIQCKYCKPL 373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mettl2	NP_647636.3	Methyltransf_25	136..238	CDD:463945	46/101 (46%)
		COG4627	187..308	CDD:443666	70/120 (58%)
METTL2B	NP_060866.2	Methyltransf_25	184..286	CDD:463945	46/101 (46%)