Protein Alignment Mettl2 and Mettl8

DIOPT Version :10

• Sequence 1: NP_647636.3
• Gene: Mettl2 / 38197
• FlyBaseID: FBgn0035247
• Length: 325
• Species: Drosophila melanogaster
• Sequence 2: XP_008760176.1
• Gene: Mettl8 / 502633
• RGDID: 1561059
• Length: 408
• Species: Rattus norvegicus
• Alignment Length: 390
• Identity: 151/390 - (38%)
• Similarity: 218/390 - (55%)
• Gaps: 80/390 - (20%)

  Fly    13 YGWQILRRLASKS--WEH----TRQRKKP----SGA------GSRVLTDAREVFEFNAWDHVQWD 61
            ||  ||:.|...:  |.:    .||.|.|    ||.      |||:|||..:|||.|.|||:||.
  Rat     4 YG--ILKVLFGMNVIWRNCICRLRQGKVPHRCQSGVHPVAPLGSRILTDPTKVFEHNMWDHMQWS 66

  Fly    62 EEQELAAKAAVAKNSTSKMEAEQKERFQTDAPKFWDSFYGIHDNRFFKDRHWLFTEFPELAPL-- 124
            :|:|..|:..|.:||.:::..|::.:|:..|.|:||:||..|.|:|||:|:||..||||:.|:
  Rat    67 KEEEDEARKKVEENSATRVAPEEQVKFENAANKYWDTFYQTHKNKFFKNRNWLLREFPEILPVDQ 131

  Fly   125 ------------------------------------------AADSAVLQ-----PRS------- 135
                                                      :|.:..|:     ||.
  Rat   132 NTKEKLGESSWDPARSSISRTQGTETHRQETFVSSEPGSRERSASNPDLEEYSRGPRKAEQFPGS 196

  Fly   136 -----IFELGCGVGNTILPLLQ-YSSEPQLKVFGCDFSARAIEILRSQRQFDEKRCEVFVMDATL 194
                 |.|:|||.||::.|:|. ..:.|...::.|||:..|:|:::|...:.|..|..|:.|...
  Rat   197 KATFRILEVGCGAGNSVFPILNTLQNIPGSFLYCCDFAPEAVELVKSHEAYSEAHCSAFIHDVCD 261

  Fly   195 DHWQVPFEENSQDIIVMIFVLSAIEPKKMQRVLDNCYRYLRPGGLLLFRDYGRYDLAQLRFKSGK 259
            |....||.:.:.|:|:::||||:|.|.:||.|:....|.|:|||:|||||:||||.||||||.|:
  Rat   262 DGLAYPFPDGTLDVILLVFVLSSIHPDRMQAVIHRLSRLLKPGGMLLFRDHGRYDNAQLRFKKGR 326

  Fly   260 CMEDNFYVRGDGTMVYFFTEEELRGMMTQAGLQEEQLIVDRRLQVNRCRGLKMYRVWIQTKFRKP 324
            |:.:|||||||||..||||:.|:..|..:|||.|:|.:||.||||||.:.::|:|||:|.||:||
  Rat   327 CLSENFYVRGDGTRAYFFTKGEIHRMFCEAGLHEKQNLVDHRLQVNRKKQIQMHRVWVQGKFQKP 391

  Fly   325  324
              Rat   392  391

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mettl2	NP_647636.3	Methyltransf_25	136..238	CDD:463945	37/102 (36%)
		COG4627	187..308	CDD:443666	66/120 (55%)
Mettl8	XP_008760176.1	Methyltransf_25	202..305	CDD:463945	37/102 (36%)