Protein Alignment Mettl2 and metl-2

DIOPT Version :10

• Sequence 1: NP_647636.3
• Gene: Mettl2 / 38197
• FlyBaseID: FBgn0035247
• Length: 325
• Species: Drosophila melanogaster
• Sequence 2: NP_001040827.1
• Gene: metl-2 / 4363033
• WormBaseID: WBGene00044720
• Length: 311
• Species: Caenorhabditis elegans
• Alignment Length: 300
• Identity: 139/300 - (46%)
• Similarity: 186/300 - (62%)
• Gaps: 5/300 - (1%)

  Fly    27 EHTRQRKKPSGAGSRVLTDAREVFEFNAWDHVQWDEEQELAAKAAVAKNSTSKMEAEQKERFQTD 91
            |:..::.|.:..|:|.|||..:|||.||||.|:|..||:..|:..|....:.|::.|:..|..:.
 Worm    12 ENPDEKPKCNPFGTRFLTDDTKVFEHNAWDDVEWSPEQQEEAQRIVQGQKSMKVDEEKAMRLLST 76

  Fly    92 APKFWDSFYGIHDNRFFKDRHWLFTEFPELAPLAADSAVLQPR--SIFELGCGVGNTILPLLQY- 153
            ....||:||..::|||||||:||..|||||.  ..|.:.||..  .|.|:|||||||..||||.
 Worm    77 PADQWDAFYAHNENRFFKDRNWLLKEFPELN--VEDESNLQKEKIEILEVGCGVGNTTFPLLQVN 139

  Fly   154 SSEPQLKVFGCDFSARAIEILRSQRQFDEKRCEVFVMDATLDHWQVPFEENSQDIIVMIFVLSAI 218
            :|..:|.:..||::..||.:|:||..:|.::...||.|.|....|......|.|.||.|:|||||
 Worm   140 NSSSRLMLHSCDYAPNAIRVLKSQDAYDPEKMNAFVWDITQPASQEAPNVGSLDYIVCIYVLSAI 204

  Fly   219 EPKKMQRVLDNCYRYLRPGGLLLFRDYGRYDLAQLRFKSGKCMEDNFYVRGDGTMVYFFTEEELR 283
            .|..::..|.|..|.|:|||.||.:|||||||.|||||..:.::.|.|.|||||:||||..|||.
 Worm   205 HPDNIKNALKNLVRLLKPGGSLLLKDYGRYDLTQLRFKKDRLIDGNLYCRGDGTLVYFFDMEELE 269

  Fly   284 GMMTQAGLQEEQLIVDRRLQVNRCRGLKMYRVWIQTKFRK 323
            .::.:.|||::.:.|||||.|||.:.:||||.|||.||.|
 Worm   270 TLLAEHGLQKKVMHVDRRLIVNRAKQVKMYRQWIQGKFLK 309

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mettl2	NP_647636.3	Methyltransf_25	136..238	CDD:463945	44/102 (43%)
		COG4627	187..308	CDD:443666	62/120 (52%)
metl-2	NP_001040827.1	Methyltransf_25	121..224	CDD:463945	44/102 (43%)