Protein Alignment Mettl2 and METTL2A

DIOPT Version :10

• Sequence 1: NP_647636.3
• Gene: Mettl2 / 38197
• FlyBaseID: FBgn0035247
• Length: 325
• Species: Drosophila melanogaster
• Sequence 2: NP_859076.3
• Gene: METTL2A / 339175
• HGNCID: 25755
• Length: 378
• Species: Homo sapiens
• Alignment Length: 368
• Identity: 162/368 - (44%)
• Similarity: 211/368 - (57%)
• Gaps: 77/368 - (20%)

  Fly    35 PSGA-----------GSRVLTDAREVFEFNAWDHVQWDEEQELAAKAAVAKNSTSKMEAEQKERF 88
            |.||           |||.|.|...||..||||:|:|.|||..||:..|.:||..::..|::..:
Human     6 PEGAPAVLADKRQQFGSRFLRDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQRVCQEKQVDY 70

  Fly    89 QTDAPKFWDSFYGIHDNRFFKDRHWLFTEFPELAP------------------------------ 123
            :.:|.|:|:.||.||:|.|||||||||||||||||
Human    71 EINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENKSEVPECRNNEDGPGL 135

  Fly   124 -------------------LAADSAVLQPRS-----------------IFELGCGVGNTILPLLQ 152
                               |..:..|.|..|                 |.|:|||||||:.|:||
Human   136 IMEEQHKCSSKSLEHKTQTLPVEENVTQKISDLEICADEFPGSSATYRILEVGCGVGNTVFPILQ 200

  Fly   153 YSSEPQLKVFGCDFSARAIEILRSQRQFDEKRCEVFVMDATLDHWQVPFEENSQDIIVMIFVLSA 217
            .:::|.|.|:.||||:.|||::::..::|..||..||.|...:....|..:.|.|||::||||||
Human   201 TNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDLCDEEKSYPVPKGSLDIIILIFVLSA 265

  Fly   218 IEPKKMQRVLDNCYRYLRPGGLLLFRDYGRYDLAQLRFKSGKCMEDNFYVRGDGTMVYFFTEEEL 282
            |.|.|||:.::...|.|:|||::|.|||||||:||||||.|:|:..|||||||||.|||||:|||
Human   266 IVPDKMQKAINRLSRLLKPGGMMLLRDYGRYDMAQLRFKKGQCLSGNFYVRGDGTRVYFFTQEEL 330

  Fly   283 RGMMTQAGLQEEQLIVDRRLQVNRCRGLKMYRVWIQTKFRKPL 325
            ..:.|.|||::.|.:|||||||||.:.|.|||||||.|:.|||
Human   331 DTLFTTAGLEKVQNLVDRRLQVNRGKQLTMYRVWIQCKYCKPL 373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mettl2	NP_647636.3	Methyltransf_25	136..238	CDD:463945	47/101 (47%)
		COG4627	187..308	CDD:443666	71/120 (59%)
METTL2A	NP_859076.3	Methyltransf_25	184..286	CDD:463945	47/101 (47%)