Protein Alignment Mettl2 and Mettl8

DIOPT Version :10

• Sequence 1: NP_647636.3
• Gene: Mettl2 / 38197
• FlyBaseID: FBgn0035247
• Length: 325
• Species: Drosophila melanogaster
• Sequence 2: NP_663499.2
• Gene: Mettl8 / 228019
• MGIID: 2385142
• Length: 388
• Species: Mus musculus
• Alignment Length: 367
• Identity: 147/367 - (40%)
• Similarity: 210/367 - (57%)
• Gaps: 72/367 - (19%)

  Fly    30 RQRKKP----SGA------GSRVLTDAREVFEFNAWDHVQWDEEQELAAKAAVAKNSTSKMEAEQ 84
            ||.|.|    ||.      |||:|||..:|||.|.|||:||.:|:|.||:..|.:||.:::..|:
Mouse    13 RQGKVPHRCQSGVHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEDAARKKVEENSATRVAPEE 77

  Fly    85 KERFQTDAPKFWDSFYGIHDNRFFKDRHWLFTEFPELAPL------------------------- 124
            :.:|::||.|:||.||..|.|:|||:|:||..||||:.|:
Mouse    78 QVKFESDANKYWDIFYQTHKNKFFKNRNWLLREFPEILPVNQNTKEKVGESSWDQVGSSISRTQG 142

  Fly   125 -------------------AADSAVLQPRS-----------------IFELGCGVGNTILPLLQ- 152
                               :|....|:..|                 |.|:|||.||::.|:|.
Mouse   143 TETHCQESFVSPEPGSRGRSAPDPDLEEYSKGPGKTEPFPGSNATFRILEVGCGAGNSVFPILNT 207

  Fly   153 YSSEPQLKVFGCDFSARAIEILRSQRQFDEKRCEVFVMDATLDHWQVPFEENSQDIIVMIFVLSA 217
            ..:.|...::.|||::.|:|:::|...:.|.:|..|:.|...|....||.:...|:::::||||:
Mouse   208 LQNIPGSFLYCCDFASEAVELVKSHESYSEAQCSAFIHDVCDDGLAYPFPDGILDVVLLVFVLSS 272

  Fly   218 IEPKKMQRVLDNCYRYLRPGGLLLFRDYGRYDLAQLRFKSGKCMEDNFYVRGDGTMVYFFTEEEL 282
            |.|.:||.|.....|.|:|||:|||||:||||.||||||.|:|:.:|||||||||..||||:.|:
Mouse   273 IHPDRMQAVAHRLSRLLKPGGMLLFRDHGRYDNAQLRFKKGRCLSENFYVRGDGTRAYFFTKGEI 337

  Fly   283 RGMMTQAGLQEEQLIVDRRLQVNRCRGLKMYRVWIQTKFRKP 324
            |.|..:|||.|:|.:||.||||||.:.::|:|||||.||:||
Mouse   338 RRMFCEAGLHEKQNLVDHRLQVNRKKQVQMHRVWIQGKFQKP 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mettl2	NP_647636.3	Methyltransf_25	136..238	CDD:463945	36/102 (35%)
		COG4627	187..308	CDD:443666	66/120 (55%)
Mettl8	NP_663499.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	139..180		3/40 (8%)
		UbiE	189..309	CDD:441828	49/119 (41%)
		AdoMet_MTases	<280..346	CDD:473071	40/65 (62%)