DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCB7 and ATM1

DIOPT Version :9

Sequence 1:	NP_728642.2	Gene:	ABCB7 / 38193	FlyBaseID:	FBgn0035244	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_014030.1	Gene:	ATM1 / 855347	SGDID:	S000004916	Length:	690	Species:	Saccharomyces cerevisiae

Alignment Length:	609	Identity:	294/609 - (48%)
Similarity:	408/609 - (66%)	Gaps:	9/609 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 APEVTSKDMLRAMMAYIWPKEDPLVRKRVGISLGLLAGSKLLTVCVPFLFKGAVDTMTTLNMDTA 194
            ||.::...:|:.:..|||||.:..||.||.|:||||..:|:|.|.|||.||..:|:|.....|
Yeast    83 APTLSELKILKDLFRYIWPKGNNKVRIRVLIALGLLISAKILNVQVPFFFKQTIDSMNIAWDD-- 145

  Fly   195 PDAVLSAATAL-MLGYGIARASAAGFNELRNAVFAKVAHHSIRKIASNVFLHLHNLDLAFHLNKQ 258
            |...|.||..| :|.||:||..:..|.|||||||||||.::||.::...|.||..|||.:||::|
Yeast   146 PTVALPAAIGLTILCYGVARFGSVLFGELRNAVFAKVAQNAIRTVSLQTFQHLMKLDLGWHLSRQ 210

  Fly   259 TGALSKTIDRGSRGINFVLSAMVFNIVPTIFELALVSSILGVKCGLAFAGVSMGCVGIYAAYTLS 323
            ||.|::.:|||::||:.||:||||:|:|..||:::|..||..:.|.:||.::...:.:|:.:|:.
Yeast   211 TGGLTRAMDRGTKGISQVLTAMVFHIIPISFEISVVCGILTYQFGASFAAITFSTMLLYSIFTIK 275

  Fly   324 VTQWRTQFRVFMNQAENEAGNKAVDSLINYETVKYFNNEKYEAGCYNEVLKKYEAASLKTSSSLA 388
            .|.|||.||...|:|:|:|.:.|:|||||:|.|||||||||.|..||..|..|..:.:|.|.|||
Yeast   276 TTAWRTHFRRDANKADNKAASVALDSLINFEAVKYFNNEKYLADKYNGSLMNYRDSQIKVSQSLA 340

  Fly   389 LLNFGQNAIFSSALSLIMVLAAKEIAQGNMTVGDLVMVNALLFQLSIPLGFLGSVYREVRQALLD 453
            .||.|||.||::||:.:|.:....:..||:||||||::|.|:||||:||.|||||||:::|:|:|
Yeast   341 FLNSGQNLIFTTALTAMMYMGCTGVIGGNLTVGDLVLINQLVFQLSVPLNFLGSVYRDLKQSLID 405

  Fly   454 MRAMFTLMNVDSSIQTAANAQPLFV-DTTNSSIEFRNVSFEYEPGKPIFRDLSFTIPAGKNVAIV 517
            |..:|.|...:..|:.|  .:||.: :.....|.|.||:|.|.|.:.|.::.|||||||...|||
Yeast   406 METLFKLRKNEVKIKNA--ERPLMLPENVPYDITFENVTFGYHPDRKILKNASFTIPAGWKTAIV 468

  Fly   518 GGSGSGKSSMVRLLFRFFEPNSGKVLIGGQDISAVDLESLRKVIAVVPQDSVLFHNTIEHNIHYG 582
            |.||||||::::|:|||::|.||::||.|:||...|:::|||||.|||||:.||::||..|:.:|
Yeast   469 GSSGSGKSTILKLVFRFYDPESGRILINGRDIKEYDIDALRKVIGVVPQDTPLFNDTIWENVKFG 533

  Fly   583 NLSKSHAEVQNAARMADLHDSIMSWPGQYSTQVGERGLKLSGGEKQRVAIARAILKNTPILIFDE 647
            .:..:..||......|.|...|...|..:.|.||||||.:|||||||:||||.:|||..|:.|||
Yeast   534 RIDATDEEVITVVEKAQLAPLIKKLPQGFDTIVGERGLMISGGEKQRLAIARVLLKNARIMFFDE 598

  Fly   648 ATSSLDSITEHNILQAL-TRATSG-RTSICIAHRLSTVKDADEILVLENGRVGERGTHSELLRQN 710
            |||:||:.||..:|:.: ...||| |||:.|||||.|:.|||:|:||:||||.|.|.|.|||...
Yeast   599 ATSALDTHTEQALLRTIRDNFTSGSRTSVYIAHRLRTIADADKIIVLDNGRVREEGKHLELLAMP 663

  Fly   711 G-LYARLWETQTQQFDPSREINEE 733
            | ||..||..|........|:.::
Yeast   664 GSLYRELWTIQEDLDHLENELKDQ 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCB7	NP_728642.2	ABC_membrane	164..437	CDD:294371	132/273 (48%)
		ATM1	222..717	CDD:227590	250/498 (50%)
		P-loop_NTPase	485..720	CDD:304359	126/237 (53%)
ATM1	NP_014030.1	ATM1	174..673	CDD:227590	252/500 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342050
Domainoid	1	1.000	260	1.000	Domainoid score	I308
eggNOG	1	0.900	-	-		E1_COG5265
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3175
Inparanoid	1	1.050	542	1.000	Inparanoid score	I173
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53794
OrthoFinder	1	1.000	-	-		FOG0003749
OrthoInspector	1	1.000	-	-		oto100039
orthoMCL	1	0.900	-	-		OOG6_101840
Panther	1	1.100	-	-	LDO	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2158
TreeFam	1	0.960	-	-
	14	13.760