DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCB7 and ABCB23

DIOPT Version :9

Sequence 1:	NP_728642.2	Gene:	ABCB7 / 38193	FlyBaseID:	FBgn0035244	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_567813.1	Gene:	ABCB23 / 828981	AraportID:	AT4G28630	Length:	678	Species:	Arabidopsis thaliana

Alignment Length:	714	Identity:	347/714 - (48%)
Similarity:	461/714 - (64%)	Gaps:	59/714 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LGRAKCYTLAKGPGTHVQARVLYSSLTKVDDKNSSDAKRKKITPFTPTPGSKLLGGVFGKKAKGG 83
            |.||..|...:....|..    :||..|......|.|.....|..:|:| |.:...||
plant     9 LSRASLYHRLRSDHHHHS----FSSFIKRSSIQRSPAINAFFTDPSPSP-SPVNARVF------- 61

  Fly    84 APAAAAAKTTTLQRQRPYRPQQQQSRLCHVHIGGGSDGGSGLGKLDAPEVTSKDMLRAMMAYIWP 148
               ..:..|:|        |.|.|::                      ..:||.:||.:.:|:|.
plant    62 ---FFSTSTST--------PNQDQTK----------------------TASSKKILRTISSYLWM 93

  Fly   149 KEDPLVRKRVGISLGLLAGSKLLTVCVPFLFKGAVDTMTTLNMDTAPD------AVLSAATALML 207
            |::|.:|.||..:|..|.|:|.|.|.||||||.::|.:::.:..|..|      |..:..:::::
plant    94 KDNPELRFRVIAALACLIGAKFLNVQVPFLFKLSIDLLSSYSSSTITDSNPYLLAAFATPSSVLI 158

  Fly   208 GYGIARASAAGFNELRNAVFAKVAHHSIRKIASNVFLHLHNLDLAFHLNKQTGALSKTIDRGSRG 272
            ||||||:.::.|||||.|||:||:..:||.::..|..|||:|||.:|||::||||::.||||||.
plant   159 GYGIARSGSSAFNELRTAVFSKVSLRTIRSVSRKVLSHLHDLDLRYHLNRETGALNRIIDRGSRA 223

  Fly   273 INFVLSAMVFNIVPTIFELALVSSILGVKCGLAFAGVSMGCVGIYAAYTLSVTQWRTQFRVFMNQ 337
            ||.:|||||||:||||.|:::|:.||....|..||.::...||.|.|:||.|||:||:||..|||
plant   224 INTILSAMVFNVVPTILEISMVTGILAYNFGPVFALITSLSVGSYIAFTLVVTQYRTKFRKAMNQ 288

  Fly   338 AENEAGNKAVDSLINYETVKYFNNEKYEAGCYNEVLKKYEAASLKTSSSLALLNFGQNAIFSSAL 402
            |:|:|..:|:|||:|||||||||||.|||..|:::|.:||.|:|:|..|||.|:|||:.|||:||
plant   289 ADNDASTRAIDSLVNYETVKYFNNEDYEARKYDDLLGRYEDAALQTQKSLAFLDFGQSFIFSTAL 353

  Fly   403 SLIMVLAAKEIAQGNMTVGDLVMVNALLFQLSIPLGFLGSVYREVRQALLDMRAMFTLMNVDSSI 467
            |..|||.::.|..|.||||||||||.||||||:||.|||.||||..|.|:||:::|.|:...|.|
plant   354 STSMVLCSQGIMNGEMTVGDLVMVNGLLFQLSLPLYFLGGVYRETVQGLVDMKSLFQLLEERSDI 418

  Fly   468 ---QTAANAQPLFVDTTNSSIEFRNVSFEYEPGKPIFRDLSFTIPAGKNVAIVGGSGSGKSSMVR 529
               .|.....||.:  ...||.|.||.|.|.|.:.|...:||.:||||:|||||.||||||:::|
plant   419 GDKDTETKLPPLVL--RGGSISFENVHFSYLPERKILDGISFEVPAGKSVAIVGSSGSGKSTILR 481

  Fly   530 LLFRFFEPNSGKVLIGGQDISAVDLESLRKVIAVVPQDSVLFHNTIEHNIHYGNLSKSHAEVQNA 594
            ::||||:.:||.|.|.||||..|.|||||..|.|||||:|||::||.|||||||||.:..||.:|
plant   482 MIFRFFDTDSGNVRIDGQDIKEVTLESLRSCIGVVPQDTVLFNDTIFHNIHYGNLSATEEEVYDA 546

  Fly   595 ARMADLHDSIMSWPGQYSTQVGERGLKLSGGEKQRVAIARAILKNTPILIFDEATSSLDSITEHN 659
            ||.|.:||:||.:|.:|||.||||||.||||||||||:|||.||:..||:.||||::|||.||..
plant   547 ARRAVIHDTIMKFPDKYSTAVGERGLMLSGGEKQRVALARAFLKSPAILLCDEATNALDSKTEAE 611

  Fly   660 ILQALTRATSGRTSICIAHRLSTVKDADEILVLENGRVGERGTHSELLRQNGLYARLWETQTQQ 723
            |::......|.||.|.|||||:|....|||:|:|.|:|.|:|||..||.::|.||:||   |||
plant   612 IMKTFRSLASNRTCIFIAHRLTTAMQCDEIIVMEKGKVVEKGTHQVLLEKSGRYAKLW---TQQ 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCB7	NP_728642.2	ABC_membrane	164..437	CDD:294371	151/278 (54%)
		ATM1	222..717	CDD:227590	285/497 (57%)
		P-loop_NTPase	485..720	CDD:304359	139/234 (59%)
ABCB23	NP_567813.1	ABC_membrane	107..388	CDD:279056	152/280 (54%)
		ATM1	173..671	CDD:227590	287/502 (57%)
		ABCC_ATM1_transporter	437..672	CDD:213220	140/237 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	314	1.000	Domainoid score	I304
eggNOG	1	0.900	-	-		E1_COG5265
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3175
Inparanoid	1	1.050	641	1.000	Inparanoid score	I182
OMA	1	1.010	-	-		QHG53794
OrthoDB	1	1.010	-	-		D248727at2759
OrthoFinder	1	1.000	-	-		FOG0003749
OrthoInspector	1	1.000	-	-		otm2672
orthoMCL	1	0.900	-	-		OOG6_101840
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2158
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840