Protein Alignment ABCB7 and abcb6

DIOPT Version :9

• Sequence 1: NP_728642.2
• Gene: ABCB7 / 38193
• FlyBaseID: FBgn0035244
• Length: 743
• Species: Drosophila melanogaster
• Sequence 2: NP_001072643.1
• Gene: abcb6 / 780100
• XenbaseID: XB-GENE-1001119
• Length: 849
• Species: Xenopus tropicalis
• Alignment Length: 602
• Identity: 254/602 - (42%)
• Similarity: 374/602 - (62%)
• Gaps: 10/602 - (1%)

  Fly   136 KDMLRAMMAYIWPKEDPLVRKRVGISLGLLAGSKLLTVCVPFLFKGAVDTMT---TLNMDTAPDA 197
            |..|..:|.||||:.:..::..|.:.:||:...:.:.|.||...|..||.:|   |.|: .|...
 Frog   234 KKKLLLVMQYIWPRRNIPLQLLVALCMGLMGLERAINVFVPIYAKKIVDGLTEDSTWNI-LAVTV 297

  Fly   198 VLSAATALMLGYGIARASAAGF-NELRNAVFAKVAHHSIRKIASNVFLHLHNLDLAFHLNKQTGA 261
            .:......:.|.|   |...|| :.||..::.:|...:.|::...:|.|||:|.|.:||.::||.
 Frog   298 CIYVLLKFLQGGG---AGTTGFLSNLRTFMWIRVQQFTNREVQIRLFAHLHSLSLRWHLGRKTGE 359

  Fly   262 LSKTIDRGSRGINFVLSAMVFNIVPTIFELALVSSILGVKCGLAFAGVSMGCVGIYAAYTLSVTQ 326
            :.:::|||:..||.:||.:||:|:|||.::.:............|..:...|:.:|...|:.:|:
 Frog   360 VLRSVDRGTSSINSLLSYIVFSILPTIADIVIGIVYFTSSFNAWFGLIIFVCMTLYLTLTIIITE 424

  Fly   327 WRTQFRVFMNQAENEAGNKAVDSLINYETVKYFNNEKYEAGCYNEVLKKYEAASLKTSSSLALLN 391
            |||::|..||..:|||.::|||||:|:|||||:|.|.||.|.:|:.:.||:.:..|.::|||:||
 Frog   425 WRTKYRREMNTRDNEAKSRAVDSLLNFETVKYYNAEGYEVGRFNDSIMKYQVSEWKVNASLAMLN 489

  Fly   392 FGQNAIFSSALSLIMVLAAKEIAQGNMTVGDLVMVNALLFQLSIPLGFLGSVYREVRQALLDMRA 456
            ..||.|....|....:|.|..:.:....|||.|:....:.||..||.:.|:.||.::.:.:||..
 Frog   490 QTQNLIIGLGLLAGSLLCAYFVTENKFKVGDYVLFGTYIIQLYTPLNWFGTYYRMIQSSFIDMEN 554

  Fly   457 MFTLMNVDSSIQTAANAQPLFVDTTNSSIEFRNVSFEYEPGKPIFRDLSFTIPAGKNVAIVGGSG 521
            ||.|.|.|..::.|.||..|..  .:..|||.||.|.|..||.|.||:|||:..|:::|:||.||
 Frog   555 MFELFNEDQEVKDAVNAPALMF--RSGKIEFENVHFSYLDGKEILRDISFTVMPGQSIALVGPSG 617

  Fly   522 SGKSSMVRLLFRFFEPNSGKVLIGGQDISAVDLESLRKVIAVVPQDSVLFHNTIEHNIHYGNLSK 586
            ||||:::||||||::...|.:.:.|||||.|..||||..|.|||||:|||::||.:||.||.:|.
 Frog   618 SGKSTIIRLLFRFYDVKGGTIKVDGQDISTVRQESLRSHIGVVPQDTVLFNDTIRNNIRYGRVSA 682

  Fly   587 SHAEVQNAARMADLHDSIMSWPGQYSTQVGERGLKLSGGEKQRVAIARAILKNTPILIFDEATSS 651
            :..||:.||..||:|:.|:|:...|.||.|||||||||||||||||||.|||...|::.|||||:
 Frog   683 TDDEVEEAAAAADIHERILSFRDGYDTQTGERGLKLSGGEKQRVAIARTILKAPQIILLDEATSA 747

  Fly   652 LDSITEHNILQALTRATSGRTSICIAHRLSTVKDADEILVLENGRVGERGTHSELLRQNGLYARL 716
            ||:.||.||..:|.:..:.||:|.:|||||||.::|:||||:.|::.|||.|.|||.:.|:||.:
 Frog   748 LDTETERNIQASLAKVCANRTTIVVAHRLSTVINSDQILVLKEGQIVERGRHEELLLKGGVYAGM 812

  Fly   717 WETQTQQFDPSREINEE 733
            |:.|....:.|.:.:.|
 Frog   813 WQKQQSGSESSSDSDSE 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCB7	NP_728642.2	ABC_membrane	164..437	CDD:294371	94/276 (34%)
		ATM1	222..717	CDD:227590	225/494 (46%)
		P-loop_NTPase	485..720	CDD:304359	132/234 (56%)
abcb6	NP_001072643.1	Required for ATPase activity. /evidence=ECO:0000250|UniProtKB:Q9NP58	1..227
		Required for the lysosomal targeting. /evidence=ECO:0000250|UniProtKB:Q9NP58	1..195
		MTABC_N	6..246	CDD:318426	5/11 (45%)
		ATM1	320..815	CDD:227590	226/496 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	814..849		3/16 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248727at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920