DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCB7 and Abcb6

DIOPT Version :9

Sequence 1:	NP_728642.2	Gene:	ABCB7 / 38193	FlyBaseID:	FBgn0035244	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_076221.1	Gene:	Abcb6 / 74104	MGIID:	1921354	Length:	842	Species:	Mus musculus

Alignment Length:	633	Identity:	254/633 - (40%)
Similarity:	377/633 - (59%)	Gaps:	27/633 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 RPQQQQSRLCHVHIGGGSDGGSGLGKLDAPEVTSKDM---LRAMMAYIWPKEDPLVRKRVGISLG 163
            ||   ||...||| ....|.|...|:......|.:|:   ||.:.:|:||:..|.::..|.|.||
Mouse   210 RP---QSYTLHVH-EEDQDVGGNQGRSTDRRSTWRDLGRKLRLLSSYLWPRGSPSLQLIVLICLG 270

  Fly   164 LLAGSKLLTVCVPFLFKGAVDTMTTLNMDTAPDAVL--SAATALMLGY--GIARASAAGFNELRN 224
            |:...:.|.|.||..::..|:.:|.    .||.:.|  :..|.:.|.:  |....|....:.||.
Mouse   271 LMGLERALNVLVPIFYRDIVNLLTA----KAPWSSLAWTVTTYVFLKFLQGGGTGSTGFVSNLRT 331

  Fly   225 AVFAKVAHHSIRKIASNVFLHLHNLDLAFHLNKQTGALSKTIDRGSRGINFVLSAMVFNIVPTIF 289
            .::.:|...:.|.:...:|.|||.|.|.:||.::||.:.:.:|||:..:..:||.:||:|:||:.
Mouse   332 FLWIRVQQFTSRGVELRLFSHLHELSLRWHLGRRTGEVLRIVDRGTSSVTGLLSYLVFSIIPTLA 396

  Fly   290 ELALVSSILGVKCGLAFAGVSMG-----CVGIYAAYTLSVTQWRTQFRVFMNQAENEAGNKAVDS 349
            ::     |:|:.....|.....|     |:.:|...|:.||:||.:||..||..||....:||||
Mouse   397 DI-----IIGIIYFSMFFNAWFGLIVFLCMSLYLILTIVVTEWRAKFRRDMNTQENATRARAVDS 456

  Fly   350 LINYETVKYFNNEKYEAGCYNEVLKKYEAASLKTSSSLALLNFGQNAIFSSALSLIMVLAAKEIA 414
            |:|:|||||:..|.||...|.|.:.|::....|:::||.:||..||.:....|....:|.|..::
Mouse   457 LLNFETVKYYGAEGYEVDRYREAILKFQGLEWKSTASLVVLNQTQNLVIGLGLLAGSLLCAYFVS 521

  Fly   415 QGNMTVGDLVMVNALLFQLSIPLGFLGSVYREVRQALLDMRAMFTLMNVDSSIQTAANAQPLFVD 479
            :..:.|||.|:....:.||.:||.:.|:.||.::...:||..||.|:..::.::....|.||...
Mouse   522 EQKLQVGDFVLFGTYITQLYMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDVPGAGPLRFH 586

  Fly   480 TTNSSIEFRNVSFEYEPGKPIFRDLSFTIPAGKNVAIVGGSGSGKSSMVRLLFRFFEPNSGKVLI 544
              ...|||.||.|.|..|:...:|:|||:..|:.||:||.||:|||:::||||||::.:||.:.|
Mouse   587 --KGRIEFENVHFSYADGQETLQDVSFTVMPGQTVALVGPSGAGKSTILRLLFRFYDISSGCIRI 649

  Fly   545 GGQDISAVDLESLRKVIAVVPQDSVLFHNTIEHNIHYGNLSKSHAEVQNAARMADLHDSIMSWPG 609
            .|||||.|...|||..|.|||||:|||::||.:||.||.::...:||:.||:.|.:||:|:|:|.
Mouse   650 DGQDISQVTQISLRSHIGVVPQDTVLFNDTIANNIRYGRVTAGDSEVEAAAQAAGIHDAILSFPE 714

  Fly   610 QYSTQVGERGLKLSGGEKQRVAIARAILKNTPILIFDEATSSLDSITEHNILQALTRATSGRTSI 674
            .|.||||||||||||||||||||||.|||...|::.|||||:||:..|..|..:|.:..:.||:|
Mouse   715 GYETQVGERGLKLSGGEKQRVAIARTILKAPDIILLDEATSALDTSNERAIQASLAKVCTNRTTI 779

  Fly   675 CIAHRLSTVKDADEILVLENGRVGERGTHSELLRQNGLYARLWETQTQ 722
            .||||||||.:||:|||:::|.:.|||.|..||.:.|:||.:|:.|.|
Mouse   780 VIAHRLSTVVNADQILVIKDGCIIERGRHEALLSRGGVYAEMWQLQQQ 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCB7	NP_728642.2	ABC_membrane	164..437	CDD:294371	88/281 (31%)
		ATM1	222..717	CDD:227590	215/499 (43%)
		P-loop_NTPase	485..720	CDD:304359	129/234 (55%)
Abcb6	NP_076221.1	Required for ATPase activity. /evidence=ECO:0000250\|UniProtKB:Q9NP58	1..236		10/29 (34%)
		Required for the lysosomal targeting. /evidence=ECO:0000250\|UniProtKB:Q9NP58	1..205
		MTABC_N	6..255	CDD:292803	15/48 (31%)
		ABC_membrane	277..544	CDD:294371	87/275 (32%)
		ATM1	329..823	CDD:227590	215/500 (43%)
		ABCC_ATM1_transporter	590..825	CDD:213220	129/234 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5265
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810