DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCB7 and CG10226

DIOPT Version :9

Sequence 1:	NP_728642.2	Gene:	ABCB7 / 38193	FlyBaseID:	FBgn0035244	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_648040.1	Gene:	CG10226 / 38725	FlyBaseID:	FBgn0035695	Length:	1320	Species:	Drosophila melanogaster

Alignment Length:	528	Identity:	161/528 - (30%)
Similarity:	274/528 - (51%)	Gaps:	70/528 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 KIASNVFLHLHNLDLAFHLNKQT--GALSKTID------RGSRGI----------NFVLS-AMVF 282
            ::.|..|..:.|.::.:...|:.  ||||..:.      :|:.|.          ||:.| |:.|
  Fly   819 RMRSKTFRCIMNQEMGWFDRKENSIGALSARLSGDAASVQGAIGFPLSNIIQAFTNFICSIAIAF 883

  Fly   283 NIVPTIFELALVSSILGVKCGLAFAGVSMGCVGIYAAYTLSVTQWRTQF--RVFMNQAE--NEAG 343
               |..:||||:                  |:........|:. :..:|  :..:.:.|  .|..
  Fly   884 ---PYSWELALI------------------CLSTSPFMVASIV-FEARFGEKSALKEKEVLEETS 926

  Fly   344 NKAVDSLINYETVKYFNNEKYEAGCYNEVLKKYEAASLKTSSSLALLN-FGQNAIFSSALSLIMV 407
            ..|.:::....||.....|:.....|::.:::|....|.......|:| .|::.:| ...::.:.
  Fly   927 RIATETITQIRTVAGLRREEELIKIYDKEVERYRHQILSRLKWRGLVNSLGKSLMF-FGYAVTLT 990

  Fly   408 LAAKEIAQGNMTVGDLVMV-NALLFQLSI---PLGFLGSVYREVRQALLDMRAMFTLMNVDSSIQ 468
            ......|.|.:....::.: |.:|:.|.|   .|.|..:    ...|||....|:.:::....||
  Fly   991 YGGHMCADGKIKFETIMKISNTMLYGLFILAQSLAFTPA----FNAALLSANRMYEIIDRKPQIQ 1051

  Fly   469 TA--------ANAQPLFVDTTNSSIEFRNVSFEYEPGKP---IFRDLSFTIPAGKNVAIVGGSGS 522
            :.        .|......:.....:.:|.::|.| |.:|   :.::.:..|..|:.||:||.|||
  Fly  1052 SPESFEIQQNGNGTAYKTNVVQQGVSYRGLNFSY-PSRPHIKVLQNFNLDINQGQTVALVGASGS 1115

  Fly   523 GKSSMVRLLFRFFEPNSGKVLIGGQDI-SAVDLESLRKVIAVVPQDSVLFHNTIEHNIHYGNLSK 586
            |||:.|:||.|:::|:.||:||..:.| ..:||::||:.:.:|.|:..||..:|..||.||:.|:
  Fly  1116 GKSTCVQLLMRYYDPDEGKILIDQESIHHDMDLKTLRRRLGIVSQEPSLFEKSIADNIGYGDTSR 1180

  Fly   587 S--HAEVQNAARMADLHDSIMSWPGQYSTQVGERGLKLSGGEKQRVAIARAILKNTPILIFDEAT 649
            .  ..::..||:||:.|:.|||.|.||.|.:|.:|.:||||:|||:|||||:::|..||:.||||
  Fly  1181 QVPMQQIIEAAKMANAHEFIMSLPAQYDTVLGSKGTQLSGGQKQRIAIARAMVRNPKILLLDEAT 1245

  Fly   650 SSLDSITEHNILQALTRATSGRTSICIAHRLSTVKDADEILVLENGRVGERGTHSELLRQNGLYA 714
            |:||..:|..:.|||..|.||||.|.|||||||:::|:.|.|::.|::.|:|:||:||.:||:|:
  Fly  1246 SALDFQSERVVQQALDSACSGRTCIVIAHRLSTIQNANVICVIQAGKIVEQGSHSQLLAKNGIYS 1310

  Fly   715 RLWETQTQ 722
            :|:..||:
  Fly  1311 KLYRCQTK 1318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCB7	NP_728642.2	ABC_membrane	164..437	CDD:294371	42/227 (19%)
		ATM1	222..717	CDD:227590	158/521 (30%)
		P-loop_NTPase	485..720	CDD:304359	108/240 (45%)
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	158/519 (30%)
		ABC_membrane	<147..333	CDD:279056
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216
		ABC_membrane	749..1019	CDD:279056	41/222 (18%)
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216	108/240 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I2340
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.010